The evaluation of doxorubicin cardiomyopathy by signal averaged electrocardiography

YILMAZ, Bahattin; Sakalli, Hakan; TAŞ, Didem Arslan; Mertsoylu, Hüseyin; CANATAROĞLU, Abdullah; KARAARSLAN, OSMAN

The evaluation of doxorubicin cardiomyopathy by signal averaged electrocardiography

Hakan SAKALLI, (Sağlık Bakanlığı, Adana Numune Eğitim Ve Araştırma Hastanesi, İç Hastalıkları ve Medikal Onkoloji Bilim Dalı, Adana, Türkiye)

Didem Arslan TAŞ, (Sağlık Bakanlığı, Adana Numune Eğitim Ve Araştırma Hastanesi, İç Hastalıkları ve Romatoloji Bölümü Adana, Türkiye)

Osman KARAARSLAN, (Sağlık Bakanlığı, Adana Numune Eğitim Ve Araştırma Hastanesi, Kardiyoloji Bölümü Adana, Türkiye)

Hüseyin MERTSOYLU, (Sağlık Bakanlığı Şanlıurfa Devlet Hastanesi, İç Hastalıkları ve Medikal Onkoloji Bilim Dalı, Şanlıurfa, Türkiye)

Bahattin YILMAZ, (Samsun Üniversitesi, İç Hastalıkları ve Medikal Onkoloji Bilim Dalı, Samsun, Türkiye)

Abdullah CANATAROĞLU (Sağlık Bakanlığı, Adana Numune Eğitim Ve Araştırma Hastanesi, İç Hastalıkları Anabilim Dalı, Adana, Türkiye)

Çukurova Üniversitesi Tıp Fakültesi Dergisi

5 3

Yıl: 2013 Cilt: 38 Sayı: 2 Sayfa Aralığı: 241 - 249 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The evaluation of doxorubicin cardiomyopathy by signal averaged electrocardiography

Öz:

Giriş: Sinyal ortalamalı elektrokardiyografi miyokardiyal hasarla oldukça ilişkili olan geç potansiyeller olarak adlandırlan düşük amplitüdlü sinyalleri saptar. Bu çalışmadaki amacımız, doksorubisinin miyokardiyal yan etkileri ile sinyal ortalamalı elektrokardiyogram arasındaki potansiyel ilişkiyi araştırmaktır. Materyal ve Method: Doksorubisin içeren kemoterapi alan 48 hasta çalışmaya dahil edildi. Sinyal ortalamalı elektrokardiyografi, 3 parametre kullanılarak ölçüldü: filtrelenmiş QRS (fQRS), fQRS süresinin son 40 milisaniyesi boyunca saptanan voltajın karekökü (RMS40), fQRS in son 40 milisaniyesinden başlayarak 40μV altına düştükten sonraki geçen süre (HFLA40). Hastaların ejeksiyon fraksiyonları, ekokardiyografi ile ölçüldü. Tartışma: Bulgularımız, kümülatif doksorubisin dozları ile fQRS ve RMS40 arasında anlamlı korelasyon olduğunu düşündürmektedir. Bu yüzden sinyal ortalamalı elektrokardiyografik parametreler doksorubisin içeren tedaviler alan hastalarının prognozunu belirlemede değerli olabilir. Sonuçlar: Ortalama yaş 44 (27-70) yıl idi. Ortalama kümülatif doksorubisin dozu 475.56±98.45 mg idi. Ölçülen sinyal ortalamalı elektrokardiyografik parametrelerin ortalama süreleri şöyleydi: fQRS:78.27±10.74 milisaniye, RMS40: 115.10±50.23 ve HFLA: 21.95±8.39 mikrovolt idi. Doksorubisin dozu ile fQRS arasında pozitif korelasyon saptanırken (r=0.28, p=0.02), RMS40 arasında negatif korelasyon mevcuttu (r=-.31,p=0.03). Doksorubisin dozu ile ejeksiyon fraksiyonları arasında korelasyon saptanmadı (r=.18, p=0.22).

Anahtar Kelime:

Konular: Cerrahi

Doksorubisin kardiyotoksisitesinin sinyal ortalamalı elektrokardiyografi ile değerlendirilmesi

Öz:

Purpose: Signal-averaged electrocardiography detects low-amplitude signals designated as late potentials which are strongly related to myocardial damage. We aimed to search for the possible relation between the myocardial effects of doxorubicin and signal-averaged electrocardiographic parameters. Material and Methods: Fortyeight patients who received doxorubicin included chemotherapy were enrolled. Signal-averaged electrocardiographic parameters were detected by using 3 parameters; filtered QRS (fQRS), the square root of the voltage obtained during the last 40 milliseconds of the duration of fQRS (RMS40), the duration starting from the last 40 miliseconds of fQRS till the decrease of voltage under 40 microvolts. (HFLA40). Ejection fractions of the patients were measured by echocardiographic evaluation. Results: Median age was 44 (27-70) years. Mean cumulative doxorubicin dosage was 475.56±98.45 mg. Mean values of the measured signal-averaged electrocardiographic parameters were as follows; fQRS: 78.27±10.74 miliseconds, RMS40:115.10±50.23 and HFLA was 21.95±8.39 microvolts . The doses of doxorubicin showed a positive correlation with fQRS (r=0.28, p=0.02) and a negative correlation with RMS40 (r=-.31,p=0.03). There was no correlation between the doxorubicin dosage and the ejection fraction of the patients (r=.18, p=0.22). Conclusion: Our results suggested that significant correlations are present between fQRS and RMS40 and cumulative doxorubicin dosages. Therefore, signal-averaged electrocardiographic parameters may be of value for predicting the prognosis of the patients who have received doxorubicin included chemotherapy.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Sakalli H, TAŞ D, KARAARSLAN O, Mertsoylu H, YILMAZ B, CANATAROĞLU A (2013). The evaluation of doxorubicin cardiomyopathy by signal averaged electrocardiography. , 241 - 249.
Chicago	Sakalli Hakan,TAŞ Didem Arslan,KARAARSLAN OSMAN,Mertsoylu Hüseyin,YILMAZ Bahattin,CANATAROĞLU Abdullah The evaluation of doxorubicin cardiomyopathy by signal averaged electrocardiography. (2013): 241 - 249.
MLA	Sakalli Hakan,TAŞ Didem Arslan,KARAARSLAN OSMAN,Mertsoylu Hüseyin,YILMAZ Bahattin,CANATAROĞLU Abdullah The evaluation of doxorubicin cardiomyopathy by signal averaged electrocardiography. , 2013, ss.241 - 249.
AMA	Sakalli H,TAŞ D,KARAARSLAN O,Mertsoylu H,YILMAZ B,CANATAROĞLU A The evaluation of doxorubicin cardiomyopathy by signal averaged electrocardiography. . 2013; 241 - 249.
Vancouver	Sakalli H,TAŞ D,KARAARSLAN O,Mertsoylu H,YILMAZ B,CANATAROĞLU A The evaluation of doxorubicin cardiomyopathy by signal averaged electrocardiography. . 2013; 241 - 249.
IEEE	Sakalli H,TAŞ D,KARAARSLAN O,Mertsoylu H,YILMAZ B,CANATAROĞLU A "The evaluation of doxorubicin cardiomyopathy by signal averaged electrocardiography." , ss.241 - 249, 2013.
ISNAD	Sakalli, Hakan vd. "The evaluation of doxorubicin cardiomyopathy by signal averaged electrocardiography". (2013), 241-249.

APA	Sakalli H, TAŞ D, KARAARSLAN O, Mertsoylu H, YILMAZ B, CANATAROĞLU A (2013). The evaluation of doxorubicin cardiomyopathy by signal averaged electrocardiography. Çukurova Üniversitesi Tıp Fakültesi Dergisi, 38(2), 241 - 249.
Chicago	Sakalli Hakan,TAŞ Didem Arslan,KARAARSLAN OSMAN,Mertsoylu Hüseyin,YILMAZ Bahattin,CANATAROĞLU Abdullah The evaluation of doxorubicin cardiomyopathy by signal averaged electrocardiography. Çukurova Üniversitesi Tıp Fakültesi Dergisi 38, no.2 (2013): 241 - 249.
MLA	Sakalli Hakan,TAŞ Didem Arslan,KARAARSLAN OSMAN,Mertsoylu Hüseyin,YILMAZ Bahattin,CANATAROĞLU Abdullah The evaluation of doxorubicin cardiomyopathy by signal averaged electrocardiography. Çukurova Üniversitesi Tıp Fakültesi Dergisi, vol.38, no.2, 2013, ss.241 - 249.
AMA	Sakalli H,TAŞ D,KARAARSLAN O,Mertsoylu H,YILMAZ B,CANATAROĞLU A The evaluation of doxorubicin cardiomyopathy by signal averaged electrocardiography. Çukurova Üniversitesi Tıp Fakültesi Dergisi. 2013; 38(2): 241 - 249.
Vancouver	Sakalli H,TAŞ D,KARAARSLAN O,Mertsoylu H,YILMAZ B,CANATAROĞLU A The evaluation of doxorubicin cardiomyopathy by signal averaged electrocardiography. Çukurova Üniversitesi Tıp Fakültesi Dergisi. 2013; 38(2): 241 - 249.
IEEE	Sakalli H,TAŞ D,KARAARSLAN O,Mertsoylu H,YILMAZ B,CANATAROĞLU A "The evaluation of doxorubicin cardiomyopathy by signal averaged electrocardiography." Çukurova Üniversitesi Tıp Fakültesi Dergisi, 38, ss.241 - 249, 2013.
ISNAD	Sakalli, Hakan vd. "The evaluation of doxorubicin cardiomyopathy by signal averaged electrocardiography". Çukurova Üniversitesi Tıp Fakültesi Dergisi 38/2 (2013), 241-249.