Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation

Sökmen, Gülizar; altun, burak; AKÇAY, Ahmet; TUNCER, Cemal; ACAR, Gürkan; SÖKMEN, Abdullah; YALÇINTAŞ, Sıla; NACAR, Alper; KÖROĞLU, Sedat

Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation

Sedat KÖROĞLU, (Afşin Devlet Hastanesi, Kardiyoloji Anabilim Dalı, Kahramanmaraş, Türkiye)

Cemal TUNCER, (Sütçü İmam Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Kahramanmaraş, Türkiye)

Gürkan ACAR, (Sütçü İmam Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Kahramanmaraş, Türkiye)

Ahmet AKÇAY, (Sütçü İmam Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Kahramanmaraş, Türkiye)

Gülizar SÖKMEN, (Sütçü İmam Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Kahramanmaraş, Türkiye)

Sıla YALÇINTAŞ, (Şırnak Devlet Hastanesi, Kardiyoloji Anabilim Dalı, Şırnak, Türkiye)

Alper NACAR, (Elbistan Devlet Hastanesi, Kardiyoloji Anabilim Dalı, Kahramanmaraş, Türkiye)

Burak ALTUN, (Adıyaman Devlet Hastanesi, Kardiyoloji Anabilim Dalı, Adıyaman, Türkiye)

Abdullah SÖKMEN (Sütçü İmam Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Kahramanmaraş, Türkiye)

Türk Kardiyoloji Derneği Arşivi

0 4

Yıl: 2012 Cilt: 40 Sayı: 6 Sayfa Aralığı: 499 - 504 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation

Öz:

Amaç: Atriyum fibrilasyonu (AF) ile yangı ve oksidatif stres arasında giderek artan sayıda kanıtlar ortaya çıkmaktadır. Bu çalışmada, C-reaktif protein (CRP) ve oksidatif stres belirteçlerinin, ısrarcı AFnin başarılı farmakolojik kardiyoversiyonu sonrası nüksü öngörebileceği yönündeki hipotez test edildi. Ayrıca, bu belirteçlerin AF gelişimi ile olası ilişkisi de araştırıldı. Çalışma planı: Olgu-kontrol yöntemi kullanılarak, kanıtlanmış ısrarcı AF atağı geçiren 42 hastanın (23 kadın, 19 erkek; ort. yaş 58.4±13.6 yı) CRP, katalaz, süperoksit dismutaz (SOD) ve malondialdehit (MDA) seviyeleri, 21 olguluk kontrol grubu (9 kadın, 12 erkek, ort. yaş 58.1±6.9 yıl) ile karşılaştırıldı. Bulgular: AFli tüm hastalar 6 ay boyunca izlendi ve bu süre boyunca 17sinde AF nüks etti. Böylece, AFli hastalar nüks gösteren ve göstermeyenler olmak üzere iki gruba ayrıldı ve aynı belirteçler kullanılarak birbiriyle karşılaştırıldı. CRP, SOD ve MDA seviyeleri kontrol grubuna göre AFli hastalarda anlamlı olarak yüksekti. Bununla birlikte, sadece CRP seviyeleri nüks etmeyenlerle karşılaştırıldığında nüks görülen AFli hastalarda anlamlı olarak yüksekti. Sonuç: Yangı ve oksidatif stres belirteçlerinin ısrarcı AFli hastalarda yüksek bulunması, aritminin varlığı ile yangı ve oksidatif stresin ilişkili olabileceğini düşündürmektedir.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Israrcı atriyum fibrilasyonu oluşumu ve nüksünün serum oksidatif stres ve yangı belirteçleri ile ilişkisi

Öz:

Objectives: There is increasing evidence linking inflammation and oxidative stress to atrial fibrillation (AF). In this study, we tested the hypothesis that C-reactive protein (CRP) and oxidative stress markers can predict the recurrence of persistent AF after successful pharmacological cardioversion. A possible relationship with AF occurrence was also investigated. Study design: Using a case-control study design, CRP, catalase, superoxide dismutase (SOD), and malondialdehyde (MDA) levels of 42 patients (23 female, 19 male; mean age 58.4±13.6 years) with documented persistent AF episodes were compared with 21 controls (9 female; 12 male; mean age 58.1±6.9 years). Results: Overall AF patients were followed for 6 months, and 17 showed recurrence. Then, they were divided into two groups (recurrence and no recurrence) and compared with each other. CRP, SOD, and MDA levels were significantly higher in AF patients compared with controls. However, only CRP levels were significantly higher in patients with AF recurrence compared to those without recurrence. Conclusion: Increased markers of inflammation and oxidative stress are found in patients with persistent AF, suggesting that inflammation and oxidative stress may be associated with the presence of arrhythmia.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Chugh SS, Blackshear JL, Shen WK, Hammill SC, Gersh BJ. Epidemiology and natural history of atrial fibrillation: clinical implications. J Am Coll Cardiol 2001;37:371-8.
2. Tsang TS, Miyasaka Y, Barnes ME, Gersh BJ. Epidemiological profile of atrial fibrillation: a contemporary perspective. Prog Cardiovasc Dis 2005;48:1-8.
3. Aviles RJ, Martin DO, Apperson-Hansen C, Houghtaling PL, Rautaharju P, Kronmal RA, et al. Inflammation as a risk factor for atrial fibrillation. Circulation 2003;108:3006-10.
4. Allessie M, Ausma J, Schotten U. Electrical, contractile and structural remodeling during atrial fibrillation. Cardiovasc Res 2002;54:230-46.
5. Shiroshita-Takeshita A, Brundel BJ, Nattel S. Atrial fibrillation: basic mechanisms, remodeling and triggers. J Interv Card Electrophysiol 2005;13:181-93.
6. Korantzopoulos P, Kolettis TM, Goudevenos JA, Siogas K. Errors and pitfalls in the non-invasive management of atrial fibrillation. Int J Cardiol. 2005;104:125-30.
7. Nattel S. New ideas about atrial fibrillation 50 years on. Nature 2002;415:219-26.
8. Kannel WB, Abbott RD, Savage DD, McNamara PM. Epidemiologic features of chronic atrial fibrillation: the Framingham study. N Engl J Med 1982;306:1018-22.
9. Tieleman RG, Van Gelder IC, Crijns HJ, De Kam PJ, Van Den Berg MP, Haaksma J, et al. Early recurrences of atrial fibrillation after electrical cardioversion: a result of fibrillationinduced electrical remodeling of the atria? J Am Coll Cardiol 1998;31:167-73.
10. Wazni O, Martin DO, Marrouche NF, Shaaraoui M, Chung MK, Almahameed S, et al. C reactive protein concentration and recurrence of atrial fibrillation after electrical cardioversion. Heart 2005;91:1303-5.
11. Malouf JF, Kanagala R, Al Atawi FO, Rosales AG, Davison DE, Murali NS, et al. High sensitivity C-reactive protein: a novel predictor for recurrence of atrial fibrillation after successful cardioversion. J Am Coll Cardiol 2005;46:1284-7.
12. Watanabe E, Arakawa T, Uchiyama T, Kodama I, Hishida H. High-sensitivity C-reactive protein is predictive of successful cardioversion for atrial fibrillation and maintenance of sinus rhythm after conversion. Int J Cardiol 2006;108:346-53.
13. Zarauza J, Rodríguez Lera MJ, Fariñas Alvarez C, Hernando JP, Ceballos B, Gutiérrez B, et al. Relationship between Creactive protein level and early recurrence of atrial fibrillation after electrical cardioversion. [Article in Spanish] Rev Esp Cardiol 2006;59:125-9. [Abstract]
14. Korantzopoulos P, Kolettis TM, Kountouris E, Siogas K, Goudevenos JA. Variation of inflammatory indexes after electrical cardioversion of persistent atrial fibrillation. Is there an association with early recurrence rates? Int J Clin Pract 2005;59:881-5.
15. Cosgrave J, Foley JB, Bahadur K, Bennett K, Crean P, Walsh MJ. Inflammatory markers are not associated with outcomes following elective external cardioversion. Int J Cardiol 2006;110:373-7.
16. Buob A, Jung J, Siaplaouras S, Neuberger HR, Mewis C. Discordant regulation of CRP and NT-proBNP plasma levels after electrical cardioversion of persistent atrial fibrillation. Pacing Clin Electrophysiol 2006;29:559-63.
17. European Heart Rhythm Association; European Association for Cardio-Thoracic Surgery, Camm AJ, Kirchhof P, Lip GY, Schotten U, Savelieva I, Ernst S, et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Eur Heart J 2010;31:2369-429.
18. Draper HH, Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 1990;186:421- 31.
19. Fridovich I. Superoxide radical: an endogenous toxicant. Annu Rev Pharmacol Toxicol 1983;23:239-57.
20. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-8.
21. Engelmann MD, Svendsen JH. Inflammation in the genesis and perpetuation of atrial fibrillation. Eur Heart J 2005;26:2083-92.
22. Boos CJ, Anderson RA, Lip GY. Is atrial fibrillation an inflammatory disorder? Eur Heart J 2006;27:136-49.
23. Psychari SN, Apostolou TS, Sinos L, Hamodraka E, Liakos G, Kremastinos DT. Relation of elevated C-reactive protein and interleukin-6 levels to left atrial size and duration of episodes in patients with atrial fibrillation. Am J Cardiol 2005;95:764- 7.
24. Watanabe T, Takeishi Y, Hirono O, Itoh M, Matsui M, Nakamura K, et al. C-reactive protein elevation predicts the occurrence of atrial structural remodeling in patients with paroxysmal atrial fibrillation. Heart Vessels 2005;20:45-9.
25. Chung MK, Martin DO, Sprecher D, Wazni O, Kanderian A, Carnes CA, et al. C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation. Circulation 2001;104:2886-91.
26. Ramlawi B, Otu H, Mieno S, Boodhwani M, Sodha NR, Clements RT, et al. Oxidative stress and atrial fibrillation after cardiac surgery: a case-control study. Ann Thorac Surg 2007;84:1166-73.
27. Leftheriotis DI, Fountoulaki KT, Flevari PG, Parissis JT, Panou FK, Andreadou IT, et al. The predictive value of inflammatory and oxidative markers following the successful cardioversion of persistent lone atrial fibrillation. Int J Cardiol 2009;135:361-9.
28. Lombardi F, Tundo F, Belletti S, Mantero A, Melzi Deril GV. C-reactive protein but not atrial dysfunction predicts recurrences of atrial fibrillation after cardioversion in patients with preserved left ventricular function. J Cardiovasc Med (Hagerstown) 2008;9:581-8.
29. Korantzopoulos P, Kalantzi K, Siogas K, Goudevenos JA. Long-term prognostic value of baseline C-reactive protein in predicting recurrence of atrial fibrillation after electrical cardioversion. Pacing Clin Electrophysiol 2008;31:1272-6.
30. Loricchio ML, Cianfrocca C, Pasceri V, Bianconi L, Auriti A, Calo L, et al. Relation of C-reactive protein to long-term risk of recurrence of atrial fibrillation after electrical cardioversion. Am J Cardiol 2007;99:1421-4.

APA	KÖROĞLU S, TUNCER C, ACAR G, AKÇAY A, Sökmen G, YALÇINTAŞ S, NACAR A, altun b, SÖKMEN A (2012). Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation. , 499 - 504.
Chicago	KÖROĞLU Sedat,TUNCER Cemal,ACAR Gürkan,AKÇAY Ahmet,Sökmen Gülizar,YALÇINTAŞ Sıla,NACAR Alper,altun burak,SÖKMEN Abdullah Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation. (2012): 499 - 504.
MLA	KÖROĞLU Sedat,TUNCER Cemal,ACAR Gürkan,AKÇAY Ahmet,Sökmen Gülizar,YALÇINTAŞ Sıla,NACAR Alper,altun burak,SÖKMEN Abdullah Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation. , 2012, ss.499 - 504.
AMA	KÖROĞLU S,TUNCER C,ACAR G,AKÇAY A,Sökmen G,YALÇINTAŞ S,NACAR A,altun b,SÖKMEN A Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation. . 2012; 499 - 504.
Vancouver	KÖROĞLU S,TUNCER C,ACAR G,AKÇAY A,Sökmen G,YALÇINTAŞ S,NACAR A,altun b,SÖKMEN A Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation. . 2012; 499 - 504.
IEEE	KÖROĞLU S,TUNCER C,ACAR G,AKÇAY A,Sökmen G,YALÇINTAŞ S,NACAR A,altun b,SÖKMEN A "Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation." , ss.499 - 504, 2012.
ISNAD	KÖROĞLU, Sedat vd. "Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation". (2012), 499-504.

APA	KÖROĞLU S, TUNCER C, ACAR G, AKÇAY A, Sökmen G, YALÇINTAŞ S, NACAR A, altun b, SÖKMEN A (2012). Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation. Türk Kardiyoloji Derneği Arşivi, 40(6), 499 - 504.
Chicago	KÖROĞLU Sedat,TUNCER Cemal,ACAR Gürkan,AKÇAY Ahmet,Sökmen Gülizar,YALÇINTAŞ Sıla,NACAR Alper,altun burak,SÖKMEN Abdullah Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation. Türk Kardiyoloji Derneği Arşivi 40, no.6 (2012): 499 - 504.
MLA	KÖROĞLU Sedat,TUNCER Cemal,ACAR Gürkan,AKÇAY Ahmet,Sökmen Gülizar,YALÇINTAŞ Sıla,NACAR Alper,altun burak,SÖKMEN Abdullah Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation. Türk Kardiyoloji Derneği Arşivi, vol.40, no.6, 2012, ss.499 - 504.
AMA	KÖROĞLU S,TUNCER C,ACAR G,AKÇAY A,Sökmen G,YALÇINTAŞ S,NACAR A,altun b,SÖKMEN A Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation. Türk Kardiyoloji Derneği Arşivi. 2012; 40(6): 499 - 504.
Vancouver	KÖROĞLU S,TUNCER C,ACAR G,AKÇAY A,Sökmen G,YALÇINTAŞ S,NACAR A,altun b,SÖKMEN A Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation. Türk Kardiyoloji Derneği Arşivi. 2012; 40(6): 499 - 504.
IEEE	KÖROĞLU S,TUNCER C,ACAR G,AKÇAY A,Sökmen G,YALÇINTAŞ S,NACAR A,altun b,SÖKMEN A "Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation." Türk Kardiyoloji Derneği Arşivi, 40, ss.499 - 504, 2012.
ISNAD	KÖROĞLU, Sedat vd. "Relation of inflammatory and oxidative markers to the occurrence and recurrence of persistent atrial fibrillation". Türk Kardiyoloji Derneği Arşivi 40/6 (2012), 499-504.