TY  - JOUR
TI  - Terpenoids, essential oil composition, fatty acid pro le, and biological activities of Anatolian Salvia fruticosa Mill.
AB  - The hexane and dichloromethane extracts, obtained by re-extraction of the methanol extract of Salvia fruticosa Mill., a orded 7 diterpenoids (carnosol, carnosic acid, carnosic acid 12-methyl ether, rosmadial, isorosmanol, ferruginol, and manool), 4 triterpenoids ( -amyryltetracosanoate, oleanolic acid, ursolic acid, and erythrodiol), a steroid (3-acetylsitosterol), and aavone (salvigenin). The galls (apples) of the collected plant were separately extracted with hexane to a ord fatty acids composed mainly of oleic acid (29%), palmitoleic acid (29%), and stearic acid (23.20%), which exhibited high anticholinesterase activity, particularly against BChE. The essential oil, obtained from the aerial parts of the plant, exhibited high AChE inhibitory activity, consisting of mainly 1,8-cineol (58.89%). The antioxidant activity according to 6 complementary tests and anticholinesterase potential of the methanol extracts and triterpenoids $alpha$-amyryltetracosanoate, oleanolic acid, ursolic acid, and sitosterol acetate were also investigated, and methanol extract exhibited the highest antioxidant and anticholinesterase activity, surpassing the other tested extracts and pure compounds.
AU  - DEMİRKOZ, Ayşe Aslı Barla
AU  - KOLAK, UFUK
AU  - Öztürk, Mehmet
AU  - Topcu, Gulacti
AU  - ULUBELEN, Ayhan
AU  - KUŞMAN, Tuğba
PY  - 2013
JO  - Turkish Journal of Chemistry
VL  - 37
IS  - 4
SN  - 1300-0527
SP  - 619
EP  - 632
DB  - TRDizin
UR  - http://search/yayin/detay/146187
ER  -