Synthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivatives
Yıl: 2013 Cilt: 37 Sayı: 2 Sayfa Aralığı: 204 - 212 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022
Synthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivatives
Öz: Isatin, 1H -indoline-2,3-dione, an endogenous compound, is also a synthetically versatile molecule that possesses a diversity of biological activities including anticonvulsant, antibacterial, antifungal, antiviral, anticancer, and cytotoxic properties. Based on the promising cytotoxic activity studies on N -substituted isatin derivatives, a series of 18 derivatives of 2-(2,3-dioxo-2,3-dihydro-1H -indol-1-yl)-N-phenylacetamide were designed, synthesized, and characterized according to their analytical and spectral data. All of the compounds were evaluated for their cytotoxic activity against MCF7, A549, HeLa, and HEK293 cell lines by real time cell analyzer. Etoposide was used as a standard compound. Briefly, ortho substitutions gave better results compared to meta and para substitutions on the N−phenyl ring and compounds bearing ortho substitutions were more effective on MCF7 cell lines than A549 and HeLa cell lines. 2-(2,3- Dioxo-2,3-dihydro-1H -indol-1-yl)-N-(2-isopropylphenyl)acetamide was the most active compound against all the tested cell lines.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA | Akgul O, TARIKOĞULLARI A, KÖSE F, Ballar P, PABUÇÇUOĞLU M (2013). Synthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivatives. , 204 - 212. |
Chicago | Akgul Ozlem,TARIKOĞULLARI Ayşe Hande,KÖSE Fadime Aydnın,Ballar Petek,PABUÇÇUOĞLU MEHMET VAROL Synthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivatives. (2013): 204 - 212. |
MLA | Akgul Ozlem,TARIKOĞULLARI Ayşe Hande,KÖSE Fadime Aydnın,Ballar Petek,PABUÇÇUOĞLU MEHMET VAROL Synthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivatives. , 2013, ss.204 - 212. |
AMA | Akgul O,TARIKOĞULLARI A,KÖSE F,Ballar P,PABUÇÇUOĞLU M Synthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivatives. . 2013; 204 - 212. |
Vancouver | Akgul O,TARIKOĞULLARI A,KÖSE F,Ballar P,PABUÇÇUOĞLU M Synthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivatives. . 2013; 204 - 212. |
IEEE | Akgul O,TARIKOĞULLARI A,KÖSE F,Ballar P,PABUÇÇUOĞLU M "Synthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivatives." , ss.204 - 212, 2013. |
ISNAD | Akgul, Ozlem vd. "Synthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivatives". (2013), 204-212. |
APA | Akgul O, TARIKOĞULLARI A, KÖSE F, Ballar P, PABUÇÇUOĞLU M (2013). Synthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivatives. Turkish Journal of Chemistry, 37(2), 204 - 212. |
Chicago | Akgul Ozlem,TARIKOĞULLARI Ayşe Hande,KÖSE Fadime Aydnın,Ballar Petek,PABUÇÇUOĞLU MEHMET VAROL Synthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivatives. Turkish Journal of Chemistry 37, no.2 (2013): 204 - 212. |
MLA | Akgul Ozlem,TARIKOĞULLARI Ayşe Hande,KÖSE Fadime Aydnın,Ballar Petek,PABUÇÇUOĞLU MEHMET VAROL Synthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivatives. Turkish Journal of Chemistry, vol.37, no.2, 2013, ss.204 - 212. |
AMA | Akgul O,TARIKOĞULLARI A,KÖSE F,Ballar P,PABUÇÇUOĞLU M Synthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivatives. Turkish Journal of Chemistry. 2013; 37(2): 204 - 212. |
Vancouver | Akgul O,TARIKOĞULLARI A,KÖSE F,Ballar P,PABUÇÇUOĞLU M Synthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivatives. Turkish Journal of Chemistry. 2013; 37(2): 204 - 212. |
IEEE | Akgul O,TARIKOĞULLARI A,KÖSE F,Ballar P,PABUÇÇUOĞLU M "Synthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivatives." Turkish Journal of Chemistry, 37, ss.204 - 212, 2013. |
ISNAD | Akgul, Ozlem vd. "Synthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivatives". Turkish Journal of Chemistry 37/2 (2013), 204-212. |