TY  - JOUR
TI  - Lipid peroxidation in neoplastic tissue of dogs with mammary cancer fed with different kinds of diet
AB  - Increased lipid peroxidation due to reactive oxygen species (ROS)-induced oxidative stress has been demonstrated in the neoplastic mammary tissue of dogs with malignant mammary tumors. Dietary factors implicated in ROS production may influence mammary cancer incidence or prognosis. Balanced diets (as commercial dog food is considered) may be more protective against oxidative damage than homemade diets. The purpose of this preliminary study was to compare the extent of lipid peroxidation, as evidenced by thiobarbituric acid-reactive substances (TBARS) and α-tocopherol concentration in the neoplastic mammary tissue, among dogs with mammary cancer fed with different kinds of diet (commercial or homemade). Eighteen dogs with mammary cancer, assigned into 2 groups according to diet, were used. Neoplastic and normal mammary tissue , 1 $cm^{3}$ each, was used for TBARS and α-tocopherol measurements. Serum TBARS, α-tocopherol, total cholesterol, and triglycerides were also measured. No significant differences in serum parameters evaluated were found between the 2 diet groups. The increased lipid peroxidation due to oxidative stress induction (increased TBARS and decreased α-tocopherol concentration) found in neoplastic compared to normal mammary tissue of dogs with mammary cancer was similar in both groups of dogs fed with a different kind of diet, commercial or homemade.
AU  - FYTIANOU, Anna
AU  - ASSALOUMIDIS, Nikolaos
AU  - KARAYANNOPOULOU, Maria
AU  - SAVVAS, Ioannis
AU  - KALDRYMIDOU, Eleni
AU  - PSALLA, Dimitra
PY  - 2013
JO  - Turkish Journal of Veterinary and Animal Sciences
VL  - 37
IS  - 4
SN  - 1300-0128
SP  - 449
EP  - 454
DB  - TRDizin
UR  - http://search/yayin/detay/146993
ER  -