The relation between serum cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?

Koruk, Mehmet; tarakcioglu, mehmet; özdemir, hakan; AYDINLI, Musa; KORUK, İrfan

The relation between serum cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?

İrfan KORUK, (Gaziantep Üniversitesi, Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, Gaziantep, Türkiye)

Hakan ÖZDEMİR, (Gaziantep Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Gaziantep, Türkiye)

Musa AYDINLI, (Gaziantep Üniversitesi, Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, Gaziantep, Türkiye)

Mehmet TARAKÇIOĞLU, (Gaziantep Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Gaziantep, Türkiye)

Mehmet KORUK (Gaziantep Üniversitesi, Tıp Fakültesi, Gastroenteroloji Bilim Dalı, Gaziantep, Türkiye)

Turkish Journal of Gastroenterology

2 1

Yıl: 2012 Cilt: 23 Sayı: 6 Sayfa Aralığı: 759 - 763 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The relation between serum cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?

Öz:

Giriş ve Amaç: Akut pankreatit farklı etyolojilere sekonder gelişen pankreatik enzimlerin aktivasyonu sonucu ortaya çıkan pankreatik inflamasyondur. Çoğu zaman kendini sınırlayan ve hafif klinik bulgularla seyreden bir tablo iken doku nekrozu ve ciddi organ yetmezliklerine de yol açabilir. Deneysel hayvan çalışmalarında apopitozisin akut pankreatit klinik seyri ile ilişkili olduğu ve apopitozisin arttığı durumlarda kliniğin hafif seyrettiği ve bir hücre iskelet proteini olan sitokeratin 18in apopitozis ile ilişkili olduğu gösterilmiştir. Bu çalışmada insanlarda sitokeratin 18 ile akut pankreatit klinik seyri arasındaki ilişkiyi araştırdık. Gereç ve Yöntem: Toplam 54 akut pankreatitli hasta çalışmaya dâhil edildi. Ranson kriterleri kullanılarak hastalar hafif pankreatit (hafif pankreatit grup; skor<6) ve ağır pankreatit (ağır pankreatit grup; skor≥6) olmak üzere iki gruba ayrıldı. 36 hasta (%66,7) hafif pankreatit; 18 hasta (%33,3) ağır pankreatit grubunda yer aldı. Hastaların ilk müracaatında sitokeratin 18 için serum örnekleri alındı. Bulgular: Hafif pankreatit grubunda serum sitokeratin 18 düzeyleri ağır pankreatit grubuna göre anlamlı olarak daha yüksekti (271,2±45,5 vs. 152,6±38,2 IU/L; p<0.001). Ayrıca serum sitokeratin 18 düzeyleri ile Ranson skoru arasında da negatif korelasyon gözlendi (p<0.001; r= -0.724). Sonuç: İnsanlarda yapılan bu ilk çalışma apopitozisin bir göstergesi olan serum sitokeratin 18 düzeylerinin akut pankreatit klinik seyrini önceden belirlemede bir parametre olabileceğini düşündürmektedir.

Anahtar Kelime:

Konular: Cerrahi

Serum sitokeratin 18 ile akut pankreatit arasındaki ilişki: Serolojik bir ön belirleyici olabilir mi?

Öz:

Background/aims: Acute pancreatitis is well defined as pancreatic inflammation due to the activation of pancreatic enzymes secondary to several etiological factors. In the majority of patients, the clinical symptoms are self-limited, but it can also cause tissue necrosis and severe organ failures. In experimental animal models, it has been shown that wide apoptotic cell death is related to a clinically mild presentation of acute pancreatitis. Cytokeratin 18, a cytoskeletal protein, is shown to be related with apoptosis. In this study, we aimed to show the relation between serum cytokeratin 18 and the clinical presentation of acute pancreatitis in humans. Materials and Methods: A total of 54 acute pancreatitis patients were enrolled into the study. Patients were classified as mild or severe pancreatitis according to Ranson s criteria. There were 36 (66.7%) patients in the mild pancreatitis group (score <6), and 18 (33.3%) patients in the severe pancreatitis group (score ≥6). During the first admission, blood samples were obtained for serum cytokeratin 18 levels. Results: Cytokeratin 18 levels in the mild pancreatitis group were significantly higher than in the severe pancreatitis group (271.2±45.5 vs. 152.6±38.2 IU/L; p<0.001). There was a negative correlation between the disease activity score (Ranson score) and the serum cytokeratin 18 levels (p<0.001; r= -0.724). Conclusions: This first human study suggests that cytokeratin 18 (marker of apoptosis) might be a serological predictive marker for acute pancreatitis for disease activity.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KORUK İ, özdemir h, AYDINLI M, tarakcioglu m, Koruk M (2012). The relation between serum cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?. , 759 - 763.
Chicago	KORUK İrfan,özdemir hakan,AYDINLI Musa,tarakcioglu mehmet,Koruk Mehmet The relation between serum cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?. (2012): 759 - 763.
MLA	KORUK İrfan,özdemir hakan,AYDINLI Musa,tarakcioglu mehmet,Koruk Mehmet The relation between serum cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?. , 2012, ss.759 - 763.
AMA	KORUK İ,özdemir h,AYDINLI M,tarakcioglu m,Koruk M The relation between serum cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?. . 2012; 759 - 763.
Vancouver	KORUK İ,özdemir h,AYDINLI M,tarakcioglu m,Koruk M The relation between serum cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?. . 2012; 759 - 763.
IEEE	KORUK İ,özdemir h,AYDINLI M,tarakcioglu m,Koruk M "The relation between serum cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?." , ss.759 - 763, 2012.
ISNAD	KORUK, İrfan vd. "The relation between serum cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?". (2012), 759-763.

APA	KORUK İ, özdemir h, AYDINLI M, tarakcioglu m, Koruk M (2012). The relation between serum cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?. Turkish Journal of Gastroenterology, 23(6), 759 - 763.
Chicago	KORUK İrfan,özdemir hakan,AYDINLI Musa,tarakcioglu mehmet,Koruk Mehmet The relation between serum cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?. Turkish Journal of Gastroenterology 23, no.6 (2012): 759 - 763.
MLA	KORUK İrfan,özdemir hakan,AYDINLI Musa,tarakcioglu mehmet,Koruk Mehmet The relation between serum cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?. Turkish Journal of Gastroenterology, vol.23, no.6, 2012, ss.759 - 763.
AMA	KORUK İ,özdemir h,AYDINLI M,tarakcioglu m,Koruk M The relation between serum cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?. Turkish Journal of Gastroenterology. 2012; 23(6): 759 - 763.
Vancouver	KORUK İ,özdemir h,AYDINLI M,tarakcioglu m,Koruk M The relation between serum cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?. Turkish Journal of Gastroenterology. 2012; 23(6): 759 - 763.
IEEE	KORUK İ,özdemir h,AYDINLI M,tarakcioglu m,Koruk M "The relation between serum cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?." Turkish Journal of Gastroenterology, 23, ss.759 - 763, 2012.
ISNAD	KORUK, İrfan vd. "The relation between serum cytokeratin 18 and acute pancreatitis: Can it be a serological predictive marker?". Turkish Journal of Gastroenterology 23/6 (2012), 759-763.