Kanser tedavisinde mTOR sinyal yolağı ve mTOR inhibitörleri

Işıkdoğan, Abdurrahman; Küçüköner, Mehmet

Kanser tedavisinde mTOR sinyal yolağı ve mTOR inhibitörleri

Mehmet KÜÇÜKÖNER, (Dicle Üniversitesi, Tıp Fakültesi, Tıbbi Onkoloji Bilim Dalı, Diyarbakır, Türkiye)

Abdurrahman IŞIKDOĞAN (Dicle Üniversitesi, Tıp Fakültesi, Tıbbi Onkoloji Bilim Dalı, Diyarbakır, Türkiye)

Dicle Tıp Dergisi

222 19

Yıl: 2013 Cilt: 40 Sayı: 1 Sayfa Aralığı: 156 - 160 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Kanser tedavisinde mTOR sinyal yolağı ve mTOR inhibitörleri

Öz:

mTOR (Rapamisin protein kompleksinin memeli hedefi)hücre büyümesi ve metabolizmasında önemli role sahiptir. Kanserde önemli olduğu saptanan üç temel sinyalizasyon yolu; (PI3K)/AKT kinaz zinciri, protein kinaz C ailesi (PKC) ve mitojenle aktive olan protein kinaz (MAPK)/Rasvardır. mTOR; PI3K/AKT sinyal yolağının akış aşağı aktivasyonunda anahtar bir kinazdır. Bu yolaklar sıklıkla kanserde bozulur ve bu yüzden de mTOR önemli bir antitümör hedeftir. Antikanser ajanlar olarak mTOR inhibitörlerirapamisin ve ondan türetilmiş temsirolimus, everolimusve ridaforolimus sonradan deforolimus oluşturmaktadır.mTOR inhibitörleri birçok kanser tipinde önemli bir hedeftir.

Anahtar Kelime:

Konular: Cerrahi

mTOR signaling pathway and mTOR inhibitors in the treatment of cancer

Öz:

Mammalian target of rapamycin (mTOR) plays a major role in the regulation of protein translation, cell growth, and metabolism. Three basic signalling pathways that have been described as important in cancer including the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR kinase cascade, the protein kinase C (PKC) family, and the mito- gen-activated protein kinase (MAPK)/Ras signalling cas- cades. mTOR has been defined as a key kinase acting downstream of the activation of PI3K/AKT. These path- ways are frequently deteriorated in cancer, and therefore mTOR inhibition is a important antitumor target. mTOR inhibitors include rapamycin (i.e. sirolimus) and its deriva- tives; temsirolimus, everolimus, ridaforolimus and defo- rolimus. mTOR inhibitors has the important potential to provide anticancer activity in many tumor types.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Küçüköner M, Işıkdoğan A (2013). Kanser tedavisinde mTOR sinyal yolağı ve mTOR inhibitörleri. , 156 - 160.
Chicago	Küçüköner Mehmet,Işıkdoğan Abdurrahman Kanser tedavisinde mTOR sinyal yolağı ve mTOR inhibitörleri. (2013): 156 - 160.
MLA	Küçüköner Mehmet,Işıkdoğan Abdurrahman Kanser tedavisinde mTOR sinyal yolağı ve mTOR inhibitörleri. , 2013, ss.156 - 160.
AMA	Küçüköner M,Işıkdoğan A Kanser tedavisinde mTOR sinyal yolağı ve mTOR inhibitörleri. . 2013; 156 - 160.
Vancouver	Küçüköner M,Işıkdoğan A Kanser tedavisinde mTOR sinyal yolağı ve mTOR inhibitörleri. . 2013; 156 - 160.
IEEE	Küçüköner M,Işıkdoğan A "Kanser tedavisinde mTOR sinyal yolağı ve mTOR inhibitörleri." , ss.156 - 160, 2013.
ISNAD	Küçüköner, Mehmet - Işıkdoğan, Abdurrahman. "Kanser tedavisinde mTOR sinyal yolağı ve mTOR inhibitörleri". (2013), 156-160.

APA	Küçüköner M, Işıkdoğan A (2013). Kanser tedavisinde mTOR sinyal yolağı ve mTOR inhibitörleri. Dicle Tıp Dergisi, 40(1), 156 - 160.
Chicago	Küçüköner Mehmet,Işıkdoğan Abdurrahman Kanser tedavisinde mTOR sinyal yolağı ve mTOR inhibitörleri. Dicle Tıp Dergisi 40, no.1 (2013): 156 - 160.
MLA	Küçüköner Mehmet,Işıkdoğan Abdurrahman Kanser tedavisinde mTOR sinyal yolağı ve mTOR inhibitörleri. Dicle Tıp Dergisi, vol.40, no.1, 2013, ss.156 - 160.
AMA	Küçüköner M,Işıkdoğan A Kanser tedavisinde mTOR sinyal yolağı ve mTOR inhibitörleri. Dicle Tıp Dergisi. 2013; 40(1): 156 - 160.
Vancouver	Küçüköner M,Işıkdoğan A Kanser tedavisinde mTOR sinyal yolağı ve mTOR inhibitörleri. Dicle Tıp Dergisi. 2013; 40(1): 156 - 160.
IEEE	Küçüköner M,Işıkdoğan A "Kanser tedavisinde mTOR sinyal yolağı ve mTOR inhibitörleri." Dicle Tıp Dergisi, 40, ss.156 - 160, 2013.
ISNAD	Küçüköner, Mehmet - Işıkdoğan, Abdurrahman. "Kanser tedavisinde mTOR sinyal yolağı ve mTOR inhibitörleri". Dicle Tıp Dergisi 40/1 (2013), 156-160.