The effectiveness of a new hemostatic agent (Ankaferd Blood Stopper) for the control of bleeding following tooth extraction in hemophilia: A controlled clinical trial

Zulfikar, Bulent; KAZANCIOĞLU, Hakkı Oğuz; ÇAKIR, Onur; Ak, Gülsüm

The effectiveness of a new hemostatic agent (Ankaferd Blood Stopper) for the control of bleeding following tooth extraction in hemophilia: A controlled clinical trial

Hakkı Oğuz KAZANCIOĞLU, (Bezmialem Vakıf Üniversitesi, Dişhekimliği Fakültesi, Ağız, Diş ve Çene Hastalıkları ve Cerrahisi Anabilim Dalı, İstanbul, Türkiye)

Onur ÇAKIR, (Bezmialem Vakıf Üniversitesi, Dişhekimliği Fakültesi, Ağız, Diş ve Çene Hastalıkları ve Cerrahisi Anabilim Dalı, İstanbul, Türkiye)

Gülsüm AK, (Bezmialem Vakıf Üniversitesi, Dişhekimliği Fakültesi, Ağız, Diş ve Çene Hastalıkları ve Cerrahisi Anabilim Dalı, İstanbul, Türkiye)

Bülent ZÜLFİKAR (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Pediatrik Hematoloji ve Onkoloji Bilim Dalı, İstanbul, Türkiye,)

Turkish Journal of Hematology

3 2

Yıl: 2013 Cilt: 30 Sayı: 1 Sayfa Aralığı: 19 - 24 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The effectiveness of a new hemostatic agent (Ankaferd Blood Stopper) for the control of bleeding following tooth extraction in hemophilia: A controlled clinical trial

Öz:

Amaç: Yeni bir hemostatik ajan olan Ankaferd Blood Stopper (ABS)’ın hemofili hastalarında diş çekimi sonrası kanama kontrolüne etkisini değerlendirmek. Gereç ve Yöntemler: 27 hemofili hastasının basit diş çekimleri gerçekleştirildi ve 17 hastaya ABS uygulandı. Kontrol grubunda (n=10) lokal hemostaz gaz tampon uygulanarak sağlandı. ABS ile tedavi edilen grupta (tedavi grubu) lokal hemostaz ABS’nin çekim soketine uygulanması ile sağlanmıştır. Bulgular: 27 hemofili hastasından toplam 57 (21 süt ve 36 sürekli) diş çekimi gerçekleştirildi. Gruplar arasında yaş ve Faktör VIII seviyeleri açısından istatiksel olarak anlamlı fark bulunamamıştır (p>0,05). Gruplar arasında en önemli klinik farklılık ABS kullanımı ile ilişkilidir. ABS uygulanan grubun kanama süresi daha düşüktür (p=0,002). Sonuç: Bu çalışma hemofili hastalarında diş çekimi sonrasında ABS’nin etkinliğini değerlendiren ilk çalışmadır. ABS hemofili hastalarında pıhtılaşma faktörü uygulama oranını azaltmak için alternatif bir hemostatik ajan olarak düşünülebilir.

Anahtar Kelime:

Konular: Hematoloji

Hemofililerde yeni bir hemostatik Ajanın (Ankaferd Blood Stopper) diş çekimi sonrası kanama kontrolüne etkisi: Kontrollü bir klinik çalışma

Öz:

Objective: To assess the hemostatic efficacy of a new local hemostatic agent, Ankaferd Blood Stopper (ABS), for the control of bleeding following tooth extraction in hemophiliacs. Materials and Methods: Simple tooth extractions were performed in 27 hemophilia A patients. In the treatment group (n=17) local hemostasis was achieved via application of ABS to the extraction sockets, whereas in the control group (n=10) local hemostasis was achieved via direct packing with gauze. Results: In all, 57 (21 primary and 36 permanent) teeth extractions were performed in 27 hemophilia A patients. There were no significant differences in age or factor VIII level distribution between the 2 groups (p>0.05). The most significant clinical difference between the groups was associated with the use of ABS; those in the treatment group had significantly shorter duration of bleeding (p=0.002). Conclusion: This is the first study to evaluate the efficacy of ABS for the control of bleeding following tooth extraction in hemophiliacs. ABS can be considered an alternative local hemostatic agent for reducing clotting factor concentrates in hemophilia patients.

Anahtar Kelime:

Konular: Hematoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KAZANCIOĞLU H, ÇAKIR O, Ak G, Zulfikar B (2013). The effectiveness of a new hemostatic agent (Ankaferd Blood Stopper) for the control of bleeding following tooth extraction in hemophilia: A controlled clinical trial. , 19 - 24.
Chicago	KAZANCIOĞLU Hakkı Oğuz,ÇAKIR Onur,Ak Gülsüm,Zulfikar Bulent The effectiveness of a new hemostatic agent (Ankaferd Blood Stopper) for the control of bleeding following tooth extraction in hemophilia: A controlled clinical trial. (2013): 19 - 24.
MLA	KAZANCIOĞLU Hakkı Oğuz,ÇAKIR Onur,Ak Gülsüm,Zulfikar Bulent The effectiveness of a new hemostatic agent (Ankaferd Blood Stopper) for the control of bleeding following tooth extraction in hemophilia: A controlled clinical trial. , 2013, ss.19 - 24.
AMA	KAZANCIOĞLU H,ÇAKIR O,Ak G,Zulfikar B The effectiveness of a new hemostatic agent (Ankaferd Blood Stopper) for the control of bleeding following tooth extraction in hemophilia: A controlled clinical trial. . 2013; 19 - 24.
Vancouver	KAZANCIOĞLU H,ÇAKIR O,Ak G,Zulfikar B The effectiveness of a new hemostatic agent (Ankaferd Blood Stopper) for the control of bleeding following tooth extraction in hemophilia: A controlled clinical trial. . 2013; 19 - 24.
IEEE	KAZANCIOĞLU H,ÇAKIR O,Ak G,Zulfikar B "The effectiveness of a new hemostatic agent (Ankaferd Blood Stopper) for the control of bleeding following tooth extraction in hemophilia: A controlled clinical trial." , ss.19 - 24, 2013.
ISNAD	KAZANCIOĞLU, Hakkı Oğuz vd. "The effectiveness of a new hemostatic agent (Ankaferd Blood Stopper) for the control of bleeding following tooth extraction in hemophilia: A controlled clinical trial". (2013), 19-24.

APA	KAZANCIOĞLU H, ÇAKIR O, Ak G, Zulfikar B (2013). The effectiveness of a new hemostatic agent (Ankaferd Blood Stopper) for the control of bleeding following tooth extraction in hemophilia: A controlled clinical trial. Turkish Journal of Hematology, 30(1), 19 - 24.
Chicago	KAZANCIOĞLU Hakkı Oğuz,ÇAKIR Onur,Ak Gülsüm,Zulfikar Bulent The effectiveness of a new hemostatic agent (Ankaferd Blood Stopper) for the control of bleeding following tooth extraction in hemophilia: A controlled clinical trial. Turkish Journal of Hematology 30, no.1 (2013): 19 - 24.
MLA	KAZANCIOĞLU Hakkı Oğuz,ÇAKIR Onur,Ak Gülsüm,Zulfikar Bulent The effectiveness of a new hemostatic agent (Ankaferd Blood Stopper) for the control of bleeding following tooth extraction in hemophilia: A controlled clinical trial. Turkish Journal of Hematology, vol.30, no.1, 2013, ss.19 - 24.
AMA	KAZANCIOĞLU H,ÇAKIR O,Ak G,Zulfikar B The effectiveness of a new hemostatic agent (Ankaferd Blood Stopper) for the control of bleeding following tooth extraction in hemophilia: A controlled clinical trial. Turkish Journal of Hematology. 2013; 30(1): 19 - 24.
Vancouver	KAZANCIOĞLU H,ÇAKIR O,Ak G,Zulfikar B The effectiveness of a new hemostatic agent (Ankaferd Blood Stopper) for the control of bleeding following tooth extraction in hemophilia: A controlled clinical trial. Turkish Journal of Hematology. 2013; 30(1): 19 - 24.
IEEE	KAZANCIOĞLU H,ÇAKIR O,Ak G,Zulfikar B "The effectiveness of a new hemostatic agent (Ankaferd Blood Stopper) for the control of bleeding following tooth extraction in hemophilia: A controlled clinical trial." Turkish Journal of Hematology, 30, ss.19 - 24, 2013.
ISNAD	KAZANCIOĞLU, Hakkı Oğuz vd. "The effectiveness of a new hemostatic agent (Ankaferd Blood Stopper) for the control of bleeding following tooth extraction in hemophilia: A controlled clinical trial". Turkish Journal of Hematology 30/1 (2013), 19-24.