Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis

ULUDOKUMACI, Seven; METE, Bilgül; ÖZARAS, Reşat; BALKAN, İlker İnanç; Soysal, Teoman; Saltoglu, Nese

Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis

Seven ULUDOKUMACI, (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

İlker İnanç BALKAN, (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

Bilgül METE, (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

Reşat ÖZARAS, (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

Neşe SALTOĞLU, (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

Teoman SOYSAL (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

Turkish Journal of Hematology

5 1

Yıl: 2013 Cilt: 30 Sayı: 3 Sayfa Aralığı: 321 - 324 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis

Öz:

Fusarium spp. immündüşkün hastalarda dissemine enfeksiyonlara neden olan oportünistik bir küf mantarıdır. Yüksek mortalite oranları nedeniyle kesin tanıya gitmek önemlidir. Sunmakta olduğumuz olguda uzamış febril nötropenik dönemde bulunan AML tanılı 27 yaşında bir gebede Pseudomonas bakteremisi ile dissemine fusariozis eşzamanlı gelişmiş ve aynı dönemde ektima gangrenozum benzeri lezyonlar ortaya çıkmıştır. Ayırıcı tanıda deri lezyonlarının histopatolojik ve mikrobiyolojik özellikleri önemli bir yer tutmuştur. Dissemine fusariozise bağlı ektima gangrenozum benzeri lezyonlar doku kültürü ve histopatolojik incelemeler yapılmazsa kolaylıkla Pseudomonas enfeksiyonu ile ilişkili lezyonlarla karıştırılabilir.

Anahtar Kelime:

Konular: Hematoloji

Eşzamanlı pseudomonas sepsisi ve dissemine fusariozisi olan febril nötropenik hastada ektima gangrenozum benzeri lezyonlar

Öz:

Fusarium spp. is an opportunistic mold that causes disseminated infections in immunocompromised patients. It is important to make a definite diagnosis because of high mortality rates. We present the case of a 27-year-old pregnant woman diagnosed with acute myeloid leukemia with a prolonged febrile neutropenic period. She developed ecthyma gangrenosum-like lesions and simultaneously had Pseudomonas bacteremia and disseminated fusariosis. Histopathological and microbiological features of skin lesions had a critical role in differential diagnosis. Ecthyma gangrenosum-like lesions due to disseminated fusariosis might be easily misdiagnosed as lesions associated with Pseudomonas unless tissue cultures and histopathological examinations are performed.

Anahtar Kelime:

Konular: Hematoloji

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık

1. Musa MO, Al Eisa A, Halim M, Sahovic E, Gyger M, Chaudhri N, Al Mohareb F Seth P, Aslam M, Aljurf M. The spectrum of Fusarium infection in immunocompromised patients with haematological malignancies and in non- immunocompromised patients: a single institution experience over 10 years. Br J Hematol 2000;108:544-548.
2. Bodey GP, Boktour M, Mays S, Duvic M, Kontoyiannis D, Hachem R, Raad I. Skin lesions associated with Fusarium infection. J Am Acad Dermatol 2002;47:659-666.
3. Nucci M, Anaissie E. Cutaneous infection by Fusarium species in healthy and immunocompromised hosts: implications for diagnosis and management. Clin Infect Dis 2002;35:909-920.
4. Yang YS, Ahn JJ, Shin MK, Lee MH. Fusarium solani onychomycosis of the thumbnail coinfected with Pseudomonas aeruginosa: report of two cases. Mycoses 2011;54:168-171.
5. Mikulska M, Furfaro E, Del Bono V, Gualandi F Raiola AM, Molinari MP, Gritti P, Sanguinetti M, Posteraro B, Bacigalupo A, Viscoli C. Galactomannan testing might be useful for early diagnosis of fusariosis. Diagn Microbiol Infect Dis 2012;72:367-369.
6. Tortorano AM, Esposto MC, Prigitano A, Grancini A, Ossi C, Cavanna C, Cascio GL. Cross-reactivity of Fusarium spp. in the Aspergillus Galactomannan enzyme-linked immunosorbent assay. J Clin Microbiol 2012;50:1051- 1053.
7. Boutati EI, Anaissie EJ. Fusarium, a significant emerging pathogen in patients with hematologic malignancy: ten years’ experience at a cancer center and implications for management. Blood 1997;90:999-1008.
8. Jossi M, Ambrosioni J, Macedo-Vinas M, Garbino J Invasive fusariosis with prolonged fungemia in a patient with acute lymphoblastic leukemia: case report and review of the literature. Int J Infect Dis 2010;14:354-356.
9. Durand-Joly I, Alfandari S, Benchikh Z, Rodrigue M, Espinel-Ingroff A, Catteau B, Cordevant C, Camus D, Dei-Cas E, Bauters F Delhaes L, De Botton S. Successful outcome of disseminated Fusarium infection with skin localization treated with voriconazole and amphotericin B-lipid complex in a patient with acute leukemia. J Clin Microbiol 2003;41:4898-4900.
10. Guzman-Cottrill JA, Zheng X, Chadwick EG. Fusarium solani endocarditis successfully treated with liposomal amphotericin B and voriconazole. Pediatr Infect Dis J 2004;23:1059-1061.

APA	ULUDOKUMACI S, BALKAN İ, METE B, ÖZARAS R, Saltoglu N, Soysal T (2013). Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis. , 321 - 324.
Chicago	ULUDOKUMACI Seven,BALKAN İlker İnanç,METE Bilgül,ÖZARAS Reşat,Saltoglu Nese,Soysal Teoman Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis. (2013): 321 - 324.
MLA	ULUDOKUMACI Seven,BALKAN İlker İnanç,METE Bilgül,ÖZARAS Reşat,Saltoglu Nese,Soysal Teoman Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis. , 2013, ss.321 - 324.
AMA	ULUDOKUMACI S,BALKAN İ,METE B,ÖZARAS R,Saltoglu N,Soysal T Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis. . 2013; 321 - 324.
Vancouver	ULUDOKUMACI S,BALKAN İ,METE B,ÖZARAS R,Saltoglu N,Soysal T Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis. . 2013; 321 - 324.
IEEE	ULUDOKUMACI S,BALKAN İ,METE B,ÖZARAS R,Saltoglu N,Soysal T "Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis." , ss.321 - 324, 2013.
ISNAD	ULUDOKUMACI, Seven vd. "Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis". (2013), 321-324.

APA	ULUDOKUMACI S, BALKAN İ, METE B, ÖZARAS R, Saltoglu N, Soysal T (2013). Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis. Turkish Journal of Hematology, 30(3), 321 - 324.
Chicago	ULUDOKUMACI Seven,BALKAN İlker İnanç,METE Bilgül,ÖZARAS Reşat,Saltoglu Nese,Soysal Teoman Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis. Turkish Journal of Hematology 30, no.3 (2013): 321 - 324.
MLA	ULUDOKUMACI Seven,BALKAN İlker İnanç,METE Bilgül,ÖZARAS Reşat,Saltoglu Nese,Soysal Teoman Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis. Turkish Journal of Hematology, vol.30, no.3, 2013, ss.321 - 324.
AMA	ULUDOKUMACI S,BALKAN İ,METE B,ÖZARAS R,Saltoglu N,Soysal T Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis. Turkish Journal of Hematology. 2013; 30(3): 321 - 324.
Vancouver	ULUDOKUMACI S,BALKAN İ,METE B,ÖZARAS R,Saltoglu N,Soysal T Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis. Turkish Journal of Hematology. 2013; 30(3): 321 - 324.
IEEE	ULUDOKUMACI S,BALKAN İ,METE B,ÖZARAS R,Saltoglu N,Soysal T "Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis." Turkish Journal of Hematology, 30, ss.321 - 324, 2013.
ISNAD	ULUDOKUMACI, Seven vd. "Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis". Turkish Journal of Hematology 30/3 (2013), 321-324.