Gamma-glutamil transferaz aktivitesi ve kardiyovasküler hastalıklar

ŞAHİN, Şafak; ALTUNKAŞ, Fatih; ÇELİK, ATAÇ; KOÇ, FATİH; Karaman, Kayıhan

Gamma-glutamil transferaz aktivitesi ve kardiyovasküler hastalıklar

Fatih ALTUNKAŞ, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Tokat, Türkiye)

Kayıhan KARAMAN, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Tokat, Türkiye)

Şafak ŞAHİN, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Tokat, Türkiye)

Ataç ÇELİK, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Tokat, Türkiye)

Fatih KOÇ (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Tokat, Türkiye)

MN Kardiyoloji

34 3

Yıl: 2014 Cilt: 21 Sayı: 1 Sayfa Aralığı: 56 - 59 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Gamma-glutamil transferaz aktivitesi ve kardiyovasküler hastalıklar

Öz:

Gamma-glutamil transferaz, hepatik enflamasyonun hassas bir göstergesi olarak kullanılan önemli bir ikinci kuşak enzimatik karaci- ğer fonksiyon testidir. Ayrıca bu glikoprotein türünün düşük ağırlıklı lipoprotein kolestrolün oksidasyonunda da rol oynadığı gösteril- miştir. Yapılan çalışmalar, okside kolestrol düzeyi ile koroner arter hastalığı arasındaki ilişkiyi açıkça göstermiştir. Bütün bu bilgiler ışı- ğında testin artmış kardiyovasküler riskli bireylerde bir biyobelirteç olarak kullanımı sorgulanmaya başlanmıştır.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Gamma-glutamyl transferase activity and cardiovascular disease

Öz:

Gamma-glutamyl transferase is an important second generation enzymatic liver function test for the diagnosis of hepatic inflamma- tion. It has been shown that this type of glycoprotein had a role in the oxidation of low density lipoprotein cholesterol. Studies obvi- ously showed the relation between oxide cholesterol level and coronary artery disease. With all these information, this test started to be questioned for using as a biomarker in people with increased cardiovascular risk

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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20. Paolicchi A, Emdin M, Ghliozeni E, et al. Images in cardio- vascular medicine. Human atherosclerotic plaques con- tain gamma-glutamyl transpeptidase enzyme activity. Circulation 2004;109(11):1440.
21. Paolicchi A, Minotti G, Tonarelli P, et al. A. Gamma-glu- tamyl transpeptidase-dependent iron reduction and LDL oxidation--a potential mechanism in atherosclerosis. J Investig Med 1999;47(3):151-60.
22. Lee DH, Ha MH, Kim JH, et al. Gamma-glutamyltrans- ferase and diabetes--a 4 year follow-up study. Diabetolo- gia 2003;46(3):359-64.
23. Vasan RS. Biomarkers of cardiovascular disease: molecu- lar basis and practical considerations. Circulation 2006; 113:2335-62.
24. Ulus T, Yildirir A, Sade LE, et al. Serum gamma-glutamyl transferase activity: new high-risk criteria in acute coro- nary syndrome patients? Coron Artery Dis 2008;19(7): 489-95.
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26. Kazemi-Shirazi L, Endler G, Winkler S, Schickbauer T, Wagner O, Marsik C. Gamma glutamyltransferase and long-term survival: is it just the liver? Clin Chem 2007; 53(5):940-6.
27. Lee DH, Jacobs DR Jr, Gross M, et al. Gamma-glutamyl- transferase is a predictor of incident diabetes and hyper- tension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin Chem 2003;49(8):1358-66.
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APA	ALTUNKAŞ F, Karaman K, ŞAHİN Ş, ÇELİK A, KOÇ F (2014). Gamma-glutamil transferaz aktivitesi ve kardiyovasküler hastalıklar. , 56 - 59.
Chicago	ALTUNKAŞ Fatih,Karaman Kayıhan,ŞAHİN Şafak,ÇELİK ATAÇ,KOÇ FATİH Gamma-glutamil transferaz aktivitesi ve kardiyovasküler hastalıklar. (2014): 56 - 59.
MLA	ALTUNKAŞ Fatih,Karaman Kayıhan,ŞAHİN Şafak,ÇELİK ATAÇ,KOÇ FATİH Gamma-glutamil transferaz aktivitesi ve kardiyovasküler hastalıklar. , 2014, ss.56 - 59.
AMA	ALTUNKAŞ F,Karaman K,ŞAHİN Ş,ÇELİK A,KOÇ F Gamma-glutamil transferaz aktivitesi ve kardiyovasküler hastalıklar. . 2014; 56 - 59.
Vancouver	ALTUNKAŞ F,Karaman K,ŞAHİN Ş,ÇELİK A,KOÇ F Gamma-glutamil transferaz aktivitesi ve kardiyovasküler hastalıklar. . 2014; 56 - 59.
IEEE	ALTUNKAŞ F,Karaman K,ŞAHİN Ş,ÇELİK A,KOÇ F "Gamma-glutamil transferaz aktivitesi ve kardiyovasküler hastalıklar." , ss.56 - 59, 2014.
ISNAD	ALTUNKAŞ, Fatih vd. "Gamma-glutamil transferaz aktivitesi ve kardiyovasküler hastalıklar". (2014), 56-59.

APA	ALTUNKAŞ F, Karaman K, ŞAHİN Ş, ÇELİK A, KOÇ F (2014). Gamma-glutamil transferaz aktivitesi ve kardiyovasküler hastalıklar. MN Kardiyoloji, 21(1), 56 - 59.
Chicago	ALTUNKAŞ Fatih,Karaman Kayıhan,ŞAHİN Şafak,ÇELİK ATAÇ,KOÇ FATİH Gamma-glutamil transferaz aktivitesi ve kardiyovasküler hastalıklar. MN Kardiyoloji 21, no.1 (2014): 56 - 59.
MLA	ALTUNKAŞ Fatih,Karaman Kayıhan,ŞAHİN Şafak,ÇELİK ATAÇ,KOÇ FATİH Gamma-glutamil transferaz aktivitesi ve kardiyovasküler hastalıklar. MN Kardiyoloji, vol.21, no.1, 2014, ss.56 - 59.
AMA	ALTUNKAŞ F,Karaman K,ŞAHİN Ş,ÇELİK A,KOÇ F Gamma-glutamil transferaz aktivitesi ve kardiyovasküler hastalıklar. MN Kardiyoloji. 2014; 21(1): 56 - 59.
Vancouver	ALTUNKAŞ F,Karaman K,ŞAHİN Ş,ÇELİK A,KOÇ F Gamma-glutamil transferaz aktivitesi ve kardiyovasküler hastalıklar. MN Kardiyoloji. 2014; 21(1): 56 - 59.
IEEE	ALTUNKAŞ F,Karaman K,ŞAHİN Ş,ÇELİK A,KOÇ F "Gamma-glutamil transferaz aktivitesi ve kardiyovasküler hastalıklar." MN Kardiyoloji, 21, ss.56 - 59, 2014.
ISNAD	ALTUNKAŞ, Fatih vd. "Gamma-glutamil transferaz aktivitesi ve kardiyovasküler hastalıklar". MN Kardiyoloji 21/1 (2014), 56-59.