Rapid ultrasound score as an indicator of atherosclerosis’ clinical manifestations in a population of hypertensives: the interrelationship between flow-mediated dilatation of brachial artery, carotid intima thickness, renal resistive index and retina resistive index of central artery

Yıl: 2014 Cilt: 14 Sayı: 1 Sayfa Aralığı: 9 - 15 Metin Dili: İngilizce

Rapid ultrasound score as an indicator of atherosclerosis’ clinical manifestations in a population of hypertensives: the interrelationship between flow-mediated dilatation of brachial artery, carotid intima thickness, renal resistive index and retina resistive index of central artery

Öz:
Objective: Flow-mediated dilatation (FMD) of brachial artery, renal resistive index (RRI), retina resistive index of central artery (RRICA) and carotid intima-media thickness (IMT) have been used for ultrasound assessment of cardiovascular risk as good surrogate markers of pre- clinical atherosclerosis. We investigated the interrelationship of these four parameters and examined whether an integrated score is a good indicator of atherosclerotic disease in hypertensives. Methods: One-hundred fifty-two consecutive subjects were enrolled in this study between April 2004 and April 2005. Each patient underwent cerebral computed tomography, coronarography, carotid, renal, central retinal and femoral arteries Doppler ultrasonographic evaluation. Statistical analysis was performed using ANOVA, Fisher test, Pearson correlation and stepwise regression analyses. Results: FMD, RRICA, IMT and RRI were significantly correlated with each other. In multiple regression analysis age, pulse pressure, hypertension duration were independently related with the four parameters. Eighty-one findings of total atherosclerotic disease (ADAD were recorded overall (15 cerebrovascular disease, 20 coronary heart disease or myocardial infarction, 22 carotid plaques and 24 low limb plaques). Using an integrated score we were able to divide the population into three scoring bands. In the lowest band we classified 87 patients with 16% of total AD; in the intermediate 40 patients with 30% of total AD, in the highest 25 patients with 54% of total AD. Differences between groups were significant (p<0.05). Conclusion: A potential benefit of these integrated, low-cost and easy-to-detect parameters, is the stratification of patients with atheroscle- rotic risk. This method may prove useful in discovering those with atherosclerosis in a pre-clinical stage for whom therapy initiated before complications could reduce the risk for a cerebro-cardio-vascular event.
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  • 1. Ezzati M, Lopez AD, Rodgers A, Vander Hoorn S, Murray CJ. Selected major risk factors and global and regional burden of disease. Lancet 2002; 360: 1347-60. [CrossRef]
  • 2. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380: 2095-128. [CrossRef]
  • 3. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 2006; 367: 1747-57. [CrossRef]
  • 4. Kearney PM, Whelton M, Reynolds K, Muntner P Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet 2005; 365: 217-23. [CrossRef]
  • 5. Salonen JT, Salonen R. Ultrasound B-mode imaging in observational studies of atherosclerotic progression. Circulation 1993; 87 (suppl. II): II56-65.
  • 6. Kazmierski R, Kozubski W, Watala C. Intima-media complex thickness of common carotid artery as a risk factor for stroke. Neurol Neurochir Pol 2000; 34: 243-53.
  • 7. Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE. Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 1997; 96: 1432-7. [CrossRef]
  • 8. Burke GL, Evans GW, Riley WA, Sharrett AR, Howard G, Barnes RW, et al. Arterial wall thickness is associated with prevalent cardiovascular disease in middle-aged adults. The Atherosclerosis Risk in Communities (ARIC) Study. Stroke 1995; 26: 386-91. [CrossRef]
  • 9. Vrtovec B, Keber I, Gadzijev A, Bardorfer I, Keber D. Carotid intima- media thickness of young coronary patients. Coron Artery Dis 1999; 10: 407-11. [CrossRef]
  • 10. O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. New Engl J Med 1999; 340: 14-22. [CrossRef]
  • 11. De Groot E, Hovingh GK, Wiegman A, Duriez P Smit AJ, Fruchart JC, et al. Measurement of arterial wall thickness as a surrogate marker for atherosclerosis. Circulation 2004; 109: III33-8. [CrossRef]
  • 12. De Blois J, Stranden E, Jogestrand T, Henareh L, Agewall S. Echogenicity of the carotid intima-media complex and cardiovascular risk factors. Clin Physiol Funct Imaging 2012; 32: 400-3. [CrossRef]
  • 13. Lisowska A, Knapp M, Bolinska S, Lisowski P Krajewska A, Sobkowicz B, et al. The importance of intima-media thickness (IMT) measurements in monitoring of atherosclerosis progress after myocardial infarction. Adv Med Sci 2012; 57: 112-7. [CrossRef]
  • 14. Agewall S, Henareh L, Jogestrand T. Intima-media complex of both the brachial artery and the common carotid artery are associated with left ventricular hypertrophy in patients with previous myocardial infarction. J Hypertens 2005; 23: 119-25. [CrossRef]
  • 15. Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium derived relaxing factor. Nature 1987; 327: 524-6. [CrossRef]
  • 16. Perticone F, Ceravolo R, Pujia A, Ventura G, Iacopino S, Scozzafava A, et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation 2001; 104: 191-6. [CrossRef]
  • 17. Madden JA. Role of the vascular endothelium and plaque in acute ischemic stroke. Neurology 2012; 79(13 Suppl 1): 58-62. [CrossRef]
  • 18. Nair BM, Viswanathan V, Snehalatha C, Mohan RS, Ramachandran A. Flow mediated dilatation and carotid intimal media thickness in South Indian type 2 diabetic subjects. Diabetes Res Clin Pract 2004; 65: 13-9. [CrossRef]
  • 19. Moriguchi J, Itoh H, Harada S, Takeda K, Hatta T, Nakata T, et al. Low frequency regular exercise improves flow-mediated dilatation of subjects with mild hypertension. Hypertens Res 2005; 28: 315-21. [CrossRef]
  • 20. Kullo IJ, Malik AR, Santos S, Ehrsam JE, Turner ST. Association of cardiovascular risk factors with microvascular and conduit artery function in hypertensive subjects. Am J Hypertens 2007; 20: 735-42. [CrossRef]
  • 21. Radermacher J, Ellis S, Haller H. Renal resistance index and progression of renal disease. Hypertension 2002; 39: 699-703. [CrossRef]
  • 22. Cianci R, Martina P Cianci M, Lavini R, Stivali G, Di Donato D, et al. Ischemic nephropathy: proteinuria and renal resistance index could suggest if revascularization is recommended. Ren Fail 2010; 32: 1167-71. [CrossRef]
  • 23. Okura T, Kurata M, Irita J, Enomoto D, Jotoku M, Nagao T, et al. Renal resistance index is a marker of future renal dysfunction in patients with essential hypertension. J Nephrol 2010; 23: 175-80.
  • 24. 2003 European Society of Hypertension. European Society of Cardiology guidelines for the management of arterial Hypertension. J Hypertens 2003; 21: 1011-53. [CrossRef]
  • 25. Hiroki M, Miyashita K, Yosida H, Hirai S, Fukuyama H. Central retinal artery Doppler flow parameters reflect the severity of cerebral small-vessels disease. Stroke 2003; 34: 92-4. [CrossRef]
  • 26. Steigerwalt RD Jr, Belcaro GV, Laurora G, Cesarone MR, De Sanctis MT, Incandela L. Ocular and orbital blood flow in patients with essential hypertension treated with trandolapril. Retina 1998; 18: 539-45. [CrossRef]
  • 27. Bülent S, Hüseyin O, Nilgün E, Gülistan B, Memduh D, Burak P et al. Non invasive evaluation of endothelial function in hypertensive elderly patients. Arch Gerontol Geriatr 2005; 61-71.
  • 28. Pontremoli R, Viazzi F, Martinoli C, Ravera M, Nicolella C, Berruti V, et al. Increased renal resistive index in patients with essential hypertension: a marker of target organ damage. Nephrol Dial Transplant 1999; 14: 360-5. [CrossRef]
  • 29. Baştürk T, Akçay M, Albayrak R, Ünsal A, Ulaş T, Koç Y. Correlation between the resistive index values of renal and orbital arteries. Kidney Blood Press Res 2012; 35: 332-9. [CrossRef]
  • 30. Hashimoto M, Eto M, Akishita M, Kozaki K, Ako J, Iijima K, et al. Correlation between flow mediated vasodilatation of the brachial artery and intima-media thickness in the carotid artery in men. Arterioscler Tromb Vasc Biol 1999; 19: 2795-800. [CrossRef]
  • 31. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111-5. [CrossRef]
  • 32. Austen WG, Edwards JE, Frye RL, Gensini GG, Gott VL, Griffith LS, et al. American Heart Association: A reporting System on patients evaluated for coronary artery disease. Report of the AD HOC Committee for grading of coronary artery disease, Council on cardiovascular surgery, American heart Association. Circulation 1975; 51 suppl: 5-40. [CrossRef]
  • 33. Radermacher J, Mengel M, Ellis S, Stuht S, Hiss M, Schwarz A, et al. The renal arterial resistance index and renal allograft survival. N Engl J Med 2003; 349: 115-24. [CrossRef]
  • 34. Kobayashi K, Akishita M, Yu W, Hashimoto M, Ohni M, Toba K. Interrelationship between non-invasive measurements of atherosclerosis: flow mediated dilatation of brachial artery, carotid intima thickness, and pulse wave velocity. Atherosclerosis 2004; 173: 13-8. [CrossRef]
  • 35. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002; 39: 257-65. [CrossRef]
  • 36. Feng Q, Hedner T. Endothelium derived relaxing factor (EDRF) and nitric oxide (NO). II. Physiology, pharmacology and pathophysiological implications. Clin Physiol 1990; 10: 503-26. [CrossRef]
  • 37. Chambers J, Ueland P Obeid O, Wrigley J, Refsum H, Kooner JS. Improved vascular endothelial function after oral B vitamins: An effect mediated through reduced concentrations of free plasma homocysteine. Circulation 2000; 102: 2479-83. [CrossRef]
  • 38. Fichtlscherer S, Rosenberger G, Walter D, Breuer S, Dimmeler S, Zeiher AM. Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease. Circulation 2000; 102: 1000-6. [CrossRef]
  • 39. Simon A, Levenson J. Stratification of vascular risk in hypertension and therapeutic perspective. Am J Hypertens 1995; 8: 45-8. [CrossRef]
  • 40. Brook RD, Bard RL, Runbenfire M, Ridker PM, Rajagopalan S. Usefulness of visceral obesity (waist-hip ratio) in predicting vascular endothelial function in healthy overweight adults. Am J Cardiol 2001; 88: 1264-9. [CrossRef]
APA GRANATO C, NATALE F, RANIERI A, SICILIANO A, CASILLO B, LORENZO C, CIRILLO C, CONCILIO C, TEDESCO M, CALABRO P, GOLINO P, RUSSO M, CALABRO R (2014). Rapid ultrasound score as an indicator of atherosclerosis’ clinical manifestations in a population of hypertensives: the interrelationship between flow-mediated dilatation of brachial artery, carotid intima thickness, renal resistive index and retina resistive index of central artery. Anadolu Kardiyoloji Dergisi, 14(1), 9 - 15.
Chicago GRANATO Chiara,NATALE Francesco,RANIERI Alessandro,SICILIANO Alessandro,CASILLO Beniamino,LORENZO Chiara Di,CIRILLO Chiara,CONCILIO Claudia,TEDESCO Michele Adolfo,CALABRO Paolo,GOLINO Paolo,RUSSO Maria Giovanna,CALABRO Raffaele Rapid ultrasound score as an indicator of atherosclerosis’ clinical manifestations in a population of hypertensives: the interrelationship between flow-mediated dilatation of brachial artery, carotid intima thickness, renal resistive index and retina resistive index of central artery. Anadolu Kardiyoloji Dergisi 14, no.1 (2014): 9 - 15.
MLA GRANATO Chiara,NATALE Francesco,RANIERI Alessandro,SICILIANO Alessandro,CASILLO Beniamino,LORENZO Chiara Di,CIRILLO Chiara,CONCILIO Claudia,TEDESCO Michele Adolfo,CALABRO Paolo,GOLINO Paolo,RUSSO Maria Giovanna,CALABRO Raffaele Rapid ultrasound score as an indicator of atherosclerosis’ clinical manifestations in a population of hypertensives: the interrelationship between flow-mediated dilatation of brachial artery, carotid intima thickness, renal resistive index and retina resistive index of central artery. Anadolu Kardiyoloji Dergisi, vol.14, no.1, 2014, ss.9 - 15.
AMA GRANATO C,NATALE F,RANIERI A,SICILIANO A,CASILLO B,LORENZO C,CIRILLO C,CONCILIO C,TEDESCO M,CALABRO P,GOLINO P,RUSSO M,CALABRO R Rapid ultrasound score as an indicator of atherosclerosis’ clinical manifestations in a population of hypertensives: the interrelationship between flow-mediated dilatation of brachial artery, carotid intima thickness, renal resistive index and retina resistive index of central artery. Anadolu Kardiyoloji Dergisi. 2014; 14(1): 9 - 15.
Vancouver GRANATO C,NATALE F,RANIERI A,SICILIANO A,CASILLO B,LORENZO C,CIRILLO C,CONCILIO C,TEDESCO M,CALABRO P,GOLINO P,RUSSO M,CALABRO R Rapid ultrasound score as an indicator of atherosclerosis’ clinical manifestations in a population of hypertensives: the interrelationship between flow-mediated dilatation of brachial artery, carotid intima thickness, renal resistive index and retina resistive index of central artery. Anadolu Kardiyoloji Dergisi. 2014; 14(1): 9 - 15.
IEEE GRANATO C,NATALE F,RANIERI A,SICILIANO A,CASILLO B,LORENZO C,CIRILLO C,CONCILIO C,TEDESCO M,CALABRO P,GOLINO P,RUSSO M,CALABRO R "Rapid ultrasound score as an indicator of atherosclerosis’ clinical manifestations in a population of hypertensives: the interrelationship between flow-mediated dilatation of brachial artery, carotid intima thickness, renal resistive index and retina resistive index of central artery." Anadolu Kardiyoloji Dergisi, 14, ss.9 - 15, 2014.