The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis

ÖZKUL, Yusuf; EMİROĞULLARI, Ömer Naci; Serhatlıoğlu, Faruk; Sener, Elif Funda

The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis

Elif Funda ŞENER, (Erciyes Üniversitesi, Tıp Fakültesi, Biyoloji Anabilim Dalı, Kayseri, Türkiye)

Ömer Naci EMİROĞULLARI, (Erciyes Üniversitesi, Tıp Fakültesi, Kardiyovasküler Cerrahi Anabilim Dalı, Kayseri, Türkiye)

Faruk SERHATLIOĞLU, (Erciyes Üniversitesi, Tıp Fakültesi, Kardiyovasküler Cerrahi Anabilim Dalı, Kayseri, Türkiye)

Yusuf ÖZKUL (Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Kayseri, Türkiye)

Anadolu Kardiyoloji Dergisi

2 0

Yıl: 2014 Cilt: 14 Sayı: 3 Sayfa Aralığı: 239 - 243 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis

Öz:

Objective: Endothelial nitric oxide synthase (eNOS) gene is a candidate gene in cardiovascular and renal diseases. Several polymorphic varia- tions have been identified in eNOS gene. We investigated a potential role of arteriovenous fistula (AVF) thrombosis and intron 4 and G894T polymorphisms in chronic renal failure. Methods: We performed a case-control observational study involving 79 with/without AVF thrombosis in chronic renal failure patients. All sub- jects were genotyped by the polymerase chain reaction (PCR) and PCR-Restriction Fragment Length Polymorphism. Genotype distribution and allele frequencies were compared between groups using the chi-square test. Results: Genotype frequencies in patients with thrombosis were not significantly different from those of patients without thrombosis for eNOS G894T polymorphism (p=0.1). eNOS gene intron 4 a allele distributions seems to be associated with thrombosis in the groups. Conclusion: This study revealed that there was an association between eNOS intron 4 polymorphism and thrombosis in chronic renal failure patients. This data will be helpful in planning further eNOS association studies in vascular access thrombosis.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Sener E, EMİROĞULLARI Ö, Serhatlıoğlu F, ÖZKUL Y (2014). The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis. , 239 - 243.
Chicago	Sener Elif Funda,EMİROĞULLARI Ömer Naci,Serhatlıoğlu Faruk,ÖZKUL Yusuf The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis. (2014): 239 - 243.
MLA	Sener Elif Funda,EMİROĞULLARI Ömer Naci,Serhatlıoğlu Faruk,ÖZKUL Yusuf The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis. , 2014, ss.239 - 243.
AMA	Sener E,EMİROĞULLARI Ö,Serhatlıoğlu F,ÖZKUL Y The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis. . 2014; 239 - 243.
Vancouver	Sener E,EMİROĞULLARI Ö,Serhatlıoğlu F,ÖZKUL Y The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis. . 2014; 239 - 243.
IEEE	Sener E,EMİROĞULLARI Ö,Serhatlıoğlu F,ÖZKUL Y "The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis." , ss.239 - 243, 2014.
ISNAD	Sener, Elif Funda vd. "The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis". (2014), 239-243.

APA	Sener E, EMİROĞULLARI Ö, Serhatlıoğlu F, ÖZKUL Y (2014). The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis. Anadolu Kardiyoloji Dergisi, 14(3), 239 - 243.
Chicago	Sener Elif Funda,EMİROĞULLARI Ömer Naci,Serhatlıoğlu Faruk,ÖZKUL Yusuf The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis. Anadolu Kardiyoloji Dergisi 14, no.3 (2014): 239 - 243.
MLA	Sener Elif Funda,EMİROĞULLARI Ömer Naci,Serhatlıoğlu Faruk,ÖZKUL Yusuf The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis. Anadolu Kardiyoloji Dergisi, vol.14, no.3, 2014, ss.239 - 243.
AMA	Sener E,EMİROĞULLARI Ö,Serhatlıoğlu F,ÖZKUL Y The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis. Anadolu Kardiyoloji Dergisi. 2014; 14(3): 239 - 243.
Vancouver	Sener E,EMİROĞULLARI Ö,Serhatlıoğlu F,ÖZKUL Y The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis. Anadolu Kardiyoloji Dergisi. 2014; 14(3): 239 - 243.
IEEE	Sener E,EMİROĞULLARI Ö,Serhatlıoğlu F,ÖZKUL Y "The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis." Anadolu Kardiyoloji Dergisi, 14, ss.239 - 243, 2014.
ISNAD	Sener, Elif Funda vd. "The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis". Anadolu Kardiyoloji Dergisi 14/3 (2014), 239-243.