Impact of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae on the outcomes of transrectal needle biopsies of the prostate

Türkeri, Levent; MULAZIMOGLU, LUTFIYE; TİGEN TÜKENMEZ, Elif; ALTINKANAT GELMEZ, GÜLŞEN; ERTÜRK ŞENGEL, BUKET; Ergönül, Önder; ÖZGEN, Mahir; KORTEN, VOLKAN

Impact of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae on the outcomes of transrectal needle biopsies of the prostate

Elif TİGEN TÜKENMEZ, (Marmara Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

BUKET ERTÜRK ŞENGEL, (Marmara Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

Lütfiye MÜLAZIMOĞLU, (Marmara Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

Volkan KORTEN, (Marmara Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

Önder ERGÖNÜL, (Koç Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

GÜLŞEN ALTINKANAT GELMEZ, (Marmara Üniversitesi, Tıp Fakültesi, Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

Mahir ÖZGEN, (Marmara Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, İstanbul, Türkiye)

Levent TÜRKERİ (Marmara Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, İstanbul, Türkiye)

Marmara Medical Journal

1 0

Yıl: 2013 Cilt: 26 Sayı: 3 Sayfa Aralığı: 127 - 129 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Impact of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae on the outcomes of transrectal needle biopsies of the prostate

Öz:

Amaç: Bu çalışmada, transrektal prostat biyopsisi (TRPB)öncesi, hastalarda dışkıda geniş spektrumlu beta-laktamaz üretenEnterobacteriaceae (GSBL-ÜE) taşıyıcılığı oranları, risk faktörlerive sonuçları gösterilmesi amaçlanmıştır.Hastalar ve Yöntem: Toplam 143 TRPB yapılan hastaçalışmaya alınmıştır. Bunların 33(%23)ünde GSBL-ÜE taşıyıcılığıbulunmuştur. Ortalama hasta yaşı 62 ± 7,5 (43-81)dir.Bulgular: Tek değişkenli analizle son 2 ayda kinolon veyabaşka bir antibiyotik kullanımı, prostatit ve diabetes mellitus(DM) GSBL-ÜE taşıyıcılığı ile ilşkili bulunmuştur. Çok değişkenlianaliz, son 2 ayda kinolon kullanımı (OR: 4,865; CI: 1,45-16,1),ve DM (OR: 4,04; CI: 1,64-10) varlığını önemli faktörler olarakgöstermiştir. TRPB sonrası disüri (p<0,001), ateş (p=0,046) veüşüme-titreme (p=0,002) gelişmesi GSBL-ÜE taşıyıcılığı ile ilişkilibulunmuştur. Asemptomatik bakteriüri ve sepsis saptanmamıştır.Semptomatik üriner sistem infeksiyon oranı %19dur.Sonuç: Bu çalışma GSBL-ÜE taşıyıcılığı için biyopsi öncesi riskfaktörlerinin son 2 ayda kinolon veya diğer antibiyotik kullanımı veDM varlığı olduğunu göstermiştir. Ciddi infektif komplikasyonlarındüşük oranda olması nedeniyle profilaksi rejimlerinin değiştirilmesiönerilmemektedir.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Geniş spektrumlu beta laktamaz üreten Enterobacteriaceae taşıyıcılığının prostatın transrectal iğne biyopsisi sonuçlarına etkisi

Öz:

Objective: This study aimed to address the prevalence, the riskfactors and the results of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-PE) in patientswho had undergone transrectal needle biopsy of the prostate(TRNBP).Patients and Methods: A total of 143 patients who hadundergone TRNBP were included. Of these, 33(23%) had fecalcarriage of ESBL-PE. The mean age of the patients was 62 ± 7.5(43-81) years.Results: A univariate analysis showed that quinolone or otherantibiotic use within the last 2 months, prostatitis, and diabetesmellitus (DM) were significantly associated with the presence ofESBL-PE. A multivariate analysis showed that quinolone use withinthe past 2 months (OR: 4.865; CI: 1.45-16.1), and DM (OR: 4.04;CI: 1.64-10) were found to be significant. Development of dysuria(p<0.001), fever (p=0.046) and chills (p=0.002) after TRNBPwere shown to be related to the presence of ESBL-PE . There wasno asymptomatic bacteriuria and sepsis, the rate of symptomaticurinary tract infection was 19%.Conclusion: This study showed that pre-biopsy risk factorsfor the presence of ESBL-PE were quinolone or other antibioticuse within the last 2 months and presence of DM. Changing prophylactic regimens should not be recommended due to the low rate of severe complications.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

Pitout JDD, Nordmann P, Laupland KB, et al. Emergence of Enterobacteriaceae-producing extended-spectrum beta- lactamases (ESBLs) in the community. J Antimicrob Chemother 2005;56:529. doi: 10.1093/jac/dki166.
Valverde A, Coque TM, Sánchez-Moreno MP, Rollán A, Baquero F, Cantón R. Dramatic increase in prevalence of fecal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae during nonoutbreak situations in Spain. J Clin Microbiol 2004;42:4769- 75.
Woerther PL, Angebault C, Jacquier H, Hugede HC. Massive increase, spread, and exchange of extended spectrum β-lactamase-encoding genes among intestinal Enterobacteriaceae in hospitalized children with severe acute malnutrition in Niger. Clin Infect Dis 2011;53:677- 85. doi: 10.1093/cid/cir522.
Pallecchi L, Bartoloni A, Fiorelli C, et al. Rapid dissemination and diversity of CTX-M extended-spectrum betalactamase genes in commensal Escherichia coli from healthy children from low- resource settings of Latin America. Antimicrob Agents Chemother 2007;51:27205. doi:10.1128/AAC.00026-07.
Azap Kurt O, Arslan H, Karaman S, Togan T. Risk factors for fecal carriage of extended-spectrum beta-lactamase producing Escherichia coli and Klebsiella spp. in the community. Turk J Med Sci 2007; 37 : 31-8.
Thompson PM, Talbot RW, Packham DA, Dulake C. Transrectal biopsy of the prostate and bacteraemia. Br J Surg 1980; 67:1278.
Lindstedt S, Lindström U, Ljunggren E, Wullt B, Grabe M. Single- dose antibiotic prophylaxis in core prostate biopsy: Impact of timing and identification of risk factors. Eur Urol 2006;50:832-7.
Aus G,Ahlgren G, Bergdahl S, Hugosson J. Infection after transrectal core biopsies of the prostate: risk factors and antibiotic prophylaxis. Br J Urol 1996;77:851-5.
Valverde A, Grill F, Coque TM, et al. High rate of intestinal colonization with extended-spectrum-beta-lactamase-producing organisms in household contacts of infected community patients. J Clin Microbiol 2008;46:2796-9. doi: 10.1128/JCM.01008-08.
Ben Sallem R, Ben Slama K, Estepa V, et al. Prevalence and characterisation of extended-spectrum beta-lactamase (ESBL)- producing Escherichia coli isolates in healthy volunteers in Tunisia. Eur J Clin Microbiol Infect Dis 2012; 31:1511-6. doi: 10.1007/ s10096-011-1471-z
Vinué L, Sáenz Y, Martínez S, et al. Prevalence and diversity of extended spectrum beta-lactamases in faecal Escherichia coli isolates from healthy humans in Spain. Clin Microbiol Infect 2009;15:9546. doi: 10.1111/j.1469-0691.2009.02803.x.
Rodriguez-Bano J, Lopez-Cerero L, Navarro MD, Diaz de Alba P. Faecal carriage of extended-spectrum beta-lactamase-producing Escherichia coli: prevalence, risk factors and molecular epidemiology. J Antimicrob Chemother 2008;62:1142-9. doi: 10.1093/jac/dkn293.
Ruddick F, Sanders P, Bicknell SG, Crofts P. Sepsis rates after ultrasound-guided prostate biopsy using a bowel preparation protocol in a community hospital. J Ultrasound Med 2011;30:213-6.
Silva N, Oliveira M, Bandeira AC, Brites C. Risk factors for infection by extended-spectrum beta-lactamase producing Klebsiella pneumoniae in a tertiary hospital in Salvador, Brazil. Braz J Infect Dis 2006;10:191-3.
Rodriguez-Bano J, Navarro MD, Romero L, et al. Epidemiology and clinical features of infections caused by extended-spectrum beta- lactamase-producing escherichia coli in nonhospitalized patients. J Clin Microbiol 2004;42:1089-94.

APA	TİGEN TÜKENMEZ E, ERTÜRK ŞENGEL B, MULAZIMOGLU L, KORTEN V, Ergönül Ö, ALTINKANAT GELMEZ G, ÖZGEN M, Türkeri L (2013). Impact of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae on the outcomes of transrectal needle biopsies of the prostate. , 127 - 129.
Chicago	TİGEN TÜKENMEZ Elif,ERTÜRK ŞENGEL BUKET,MULAZIMOGLU LUTFIYE,KORTEN VOLKAN,Ergönül Önder,ALTINKANAT GELMEZ GÜLŞEN,ÖZGEN Mahir,Türkeri Levent Impact of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae on the outcomes of transrectal needle biopsies of the prostate. (2013): 127 - 129.
MLA	TİGEN TÜKENMEZ Elif,ERTÜRK ŞENGEL BUKET,MULAZIMOGLU LUTFIYE,KORTEN VOLKAN,Ergönül Önder,ALTINKANAT GELMEZ GÜLŞEN,ÖZGEN Mahir,Türkeri Levent Impact of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae on the outcomes of transrectal needle biopsies of the prostate. , 2013, ss.127 - 129.
AMA	TİGEN TÜKENMEZ E,ERTÜRK ŞENGEL B,MULAZIMOGLU L,KORTEN V,Ergönül Ö,ALTINKANAT GELMEZ G,ÖZGEN M,Türkeri L Impact of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae on the outcomes of transrectal needle biopsies of the prostate. . 2013; 127 - 129.
Vancouver	TİGEN TÜKENMEZ E,ERTÜRK ŞENGEL B,MULAZIMOGLU L,KORTEN V,Ergönül Ö,ALTINKANAT GELMEZ G,ÖZGEN M,Türkeri L Impact of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae on the outcomes of transrectal needle biopsies of the prostate. . 2013; 127 - 129.
IEEE	TİGEN TÜKENMEZ E,ERTÜRK ŞENGEL B,MULAZIMOGLU L,KORTEN V,Ergönül Ö,ALTINKANAT GELMEZ G,ÖZGEN M,Türkeri L "Impact of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae on the outcomes of transrectal needle biopsies of the prostate." , ss.127 - 129, 2013.
ISNAD	TİGEN TÜKENMEZ, Elif vd. "Impact of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae on the outcomes of transrectal needle biopsies of the prostate". (2013), 127-129.

APA	TİGEN TÜKENMEZ E, ERTÜRK ŞENGEL B, MULAZIMOGLU L, KORTEN V, Ergönül Ö, ALTINKANAT GELMEZ G, ÖZGEN M, Türkeri L (2013). Impact of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae on the outcomes of transrectal needle biopsies of the prostate. Marmara Medical Journal, 26(3), 127 - 129.
Chicago	TİGEN TÜKENMEZ Elif,ERTÜRK ŞENGEL BUKET,MULAZIMOGLU LUTFIYE,KORTEN VOLKAN,Ergönül Önder,ALTINKANAT GELMEZ GÜLŞEN,ÖZGEN Mahir,Türkeri Levent Impact of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae on the outcomes of transrectal needle biopsies of the prostate. Marmara Medical Journal 26, no.3 (2013): 127 - 129.
MLA	TİGEN TÜKENMEZ Elif,ERTÜRK ŞENGEL BUKET,MULAZIMOGLU LUTFIYE,KORTEN VOLKAN,Ergönül Önder,ALTINKANAT GELMEZ GÜLŞEN,ÖZGEN Mahir,Türkeri Levent Impact of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae on the outcomes of transrectal needle biopsies of the prostate. Marmara Medical Journal, vol.26, no.3, 2013, ss.127 - 129.
AMA	TİGEN TÜKENMEZ E,ERTÜRK ŞENGEL B,MULAZIMOGLU L,KORTEN V,Ergönül Ö,ALTINKANAT GELMEZ G,ÖZGEN M,Türkeri L Impact of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae on the outcomes of transrectal needle biopsies of the prostate. Marmara Medical Journal. 2013; 26(3): 127 - 129.
Vancouver	TİGEN TÜKENMEZ E,ERTÜRK ŞENGEL B,MULAZIMOGLU L,KORTEN V,Ergönül Ö,ALTINKANAT GELMEZ G,ÖZGEN M,Türkeri L Impact of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae on the outcomes of transrectal needle biopsies of the prostate. Marmara Medical Journal. 2013; 26(3): 127 - 129.
IEEE	TİGEN TÜKENMEZ E,ERTÜRK ŞENGEL B,MULAZIMOGLU L,KORTEN V,Ergönül Ö,ALTINKANAT GELMEZ G,ÖZGEN M,Türkeri L "Impact of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae on the outcomes of transrectal needle biopsies of the prostate." Marmara Medical Journal, 26, ss.127 - 129, 2013.
ISNAD	TİGEN TÜKENMEZ, Elif vd. "Impact of fecal carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae on the outcomes of transrectal needle biopsies of the prostate". Marmara Medical Journal 26/3 (2013), 127-129.