The relationship between ınflammatory reagents and mortality in patients over the age of 55 hospitalised in the ınternal medicine ntensive care unit from the emergency service

SEBE, AHMET; Acehan, Selen; AY, Mehmet Oğuzhan; AÇIKALIN AKPINAR, AYÇA; TOPAL, Yağmur; Gulen, Muge; ULUÖZ, Haşim Onur

The relationship between ınflammatory reagents and mortality in patients over the age of 55 hospitalised in the ınternal medicine ntensive care unit from the emergency service

Haşim Onur ULUÖZ, (Osmaniye Devlet Hastanesi, Acil Tıp Kliniği, Osmaniye, Türkiye)

Yağmur TOPAL, (Osmaniye Devlet Hastanesi, Acil Tıp Kliniği, Osmaniye, Türkiye)

Ahmet SEBE, (Çukurova Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, Adana, Türkiye)

Mehmet Oğuzhan AY, (Sağlık Bakanlığı, Adana Numune Eğitim ve Araştırma Hastanesi, Acil Tıp Kliniği, Adana, Türkiye)

AYÇA AÇIKALIN AKPINAR, (Sağlık Bakanlığı, Adana Numune Eğitim ve Araştırma Hastanesi, Acil Tıp Kliniği, Adana, Türkiye)

Müge GÜLEN, (Sağlık Bakanlığı, Adana Numune Eğitim ve Araştırma Hastanesi, Acil Tıp Kliniği, Adana, Türkiye)

Selen ACEHAN (Sağlık Bakanlığı, Adana Numune Eğitim ve Araştırma Hastanesi, Acil Tıp Kliniği, Adana, Türkiye)

Akademik Acil Tıp Dergisi

5 1

Yıl: 2013 Cilt: 12 Sayı: 1 Sayfa Aralığı: 13 - 18 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The relationship between ınflammatory reagents and mortality in patients over the age of 55 hospitalised in the ınternal medicine ntensive care unit from the emergency service

Öz:

Amaç: Çalışmamızda acil servisten yoğun bakıma yatışı uygun görülen 55 yaş üzeri hastalarda akut faz reaktanları, inflamatuvar belirteçler, APACHE-II, SAPS-II ve GKS skorları ile mortalite arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve Yöntemler: Prospektif, randomize olarak acilden dahiliye yoğun bakım ünitesine yatırılan 55 yaş üzeri hastaların alınmasının planlandığı çaışmamıza Etik Kurul onayı alındıktan sonra başlandı. Araştırmamızda verilein standart bir şekilde toplanabilmesi amacıyla standart veri toplama formu oluşturuldu. Çalışmamıza, 48i (%65.8) erkek, 25i (%34.2) kadın olmak üzere oplam 73 hasta alındı. Dahiliye yoğun bakıma yatmadan önce çalışmada kullanılmak üzere kan örneği alınarak serumda lökosit sayısı, hemoglobin, c reaktif protein (CRP), interlökin-1 (IL-1), interlökin-6 (IL-6), interlökin-10 IL-10), tümör nekroz faktör-alfa (TNF-alfa), protrombin zamanı (PTZ), aktive parsiyel tromboblastin zamanı (aPTT), albumin, ferritin düzeyleri labarauarda çalışıldı. Hastaların Glaskow koma skalası, SAPS -II skoru, APACHE-II skorları hesaplandı. Elde edilen hasta verileri SSPS 18.0 programı ile değerendirildi. Kategorik ölçümlerin gruplar arasında karşılaştırılmasında Ki Kare esti, gruplar arasında sayısal ölçümlerin karşılaştırılmasında Mann-Whitney U testi ve T testi kullanıldı. Bulgular: Eksitus ve taburcu olan hastalar arasında istatistiksel olarak anamlı bir yaş ortalaması farkı yoktu. Ortalama yatış süresi ise eksitus olan hasta grubunda daha azdı ve istatistiksel olarak anlamlı fark mevcuttu. Prognostik belirteçlerden ferritin, aPTT, SAPS-IInin yüksekliği, GKS ve albümin düşüklüğü ile mortalite arasında istatistiksel olarak anlamlı ilişki saptandı. APACHE II skoru, lökosit sayısı, hemoglobin düzeyi, PTZ, CRP, TNF-alfa, IL-1, L-6, IL-10. Sonuç: DYBÜne yatan yaşlı hastaların mortalite tahmininde; SAPS-II, GKS, erritin, albümin, aPTT ölçümlerinin kullanılabileceği tespit edildi. JAEM 2013; 12: 13-8)

Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel

Acil servisten dahiliye yoğun bakıma yatan 55 yaş üzeri hastalarda inflamatuvar belirteçler ile mortalite arasındaki ilişki

Öz:

Objective: In this study, we tried to determine the relationship between inlammatory reagents, acute phase reactants, GCS, APACHE-II, SAPS-II scores and mortality of the patients over the age of 55 hospitalised inthe internal medicine intensive care unit. Material and Methods: This study was planned as a prospective, randomized study and the patients hospitalized in the intensive care unit from the emergency medicine department were enrolled in this study following the ethics committee approval. A standard data collection form was prpeared to collect he data in a standard way. 48 (%65.8) male, 25 (%34.2) women and a total of 73 patients were included in our study. Blood samples were taken from each patient and white blood cell (WBC), hemoglobin, c-reactive protein (CRP), nterleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis actor-alpha (TNF-alpha), prothrombin time (PTZ), activated partial thromboplastin time (aPTT), albumin and ferritin levels were studied in our laboratory. Glasgow Coma Scale, SAPS-II and APACHE-II scores were calculated for each patient. SPSS for Windows version 18 package program was used for staistical analysis of the data. Chi square test was used to compare categorical measures between the groups. Mann-Whitney U test and T-test were used to compare quantitative measurements between the groups. Results: There was no statistically significant difference in mean age among patients who died and survived . Mean duration of hospitalization inthe pa- ient group who died was less than for the survived patients group but there was no statistically significant difference between groups. A significant relaionship was found between mortality and the high levels of ferritin, aPTT, SAPS-II and the low levels of albümin, GCS. No significant relationship was ound between mortality and leukocyte count, haemoglobin, PTZ, CRP, TNF- alpha, IL-1, IL-6, IL-10 and APACHE-II score. Conclusion: SAPS-II, GCS, ferritin, albumin, aPTT measurements were determined to be used in the mortality estimation of the patients hospitalised in he intensive care unit. (JAEM 2013; 12: 13-8)

Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ULUÖZ H, TOPAL Y, SEBE A, AY M, AÇIKALIN AKPINAR A, Gulen M, Acehan S (2013). The relationship between ınflammatory reagents and mortality in patients over the age of 55 hospitalised in the ınternal medicine ntensive care unit from the emergency service. , 13 - 18.
Chicago	ULUÖZ Haşim Onur,TOPAL Yağmur,SEBE AHMET,AY Mehmet Oğuzhan,AÇIKALIN AKPINAR AYÇA,Gulen Muge,Acehan Selen The relationship between ınflammatory reagents and mortality in patients over the age of 55 hospitalised in the ınternal medicine ntensive care unit from the emergency service. (2013): 13 - 18.
MLA	ULUÖZ Haşim Onur,TOPAL Yağmur,SEBE AHMET,AY Mehmet Oğuzhan,AÇIKALIN AKPINAR AYÇA,Gulen Muge,Acehan Selen The relationship between ınflammatory reagents and mortality in patients over the age of 55 hospitalised in the ınternal medicine ntensive care unit from the emergency service. , 2013, ss.13 - 18.
AMA	ULUÖZ H,TOPAL Y,SEBE A,AY M,AÇIKALIN AKPINAR A,Gulen M,Acehan S The relationship between ınflammatory reagents and mortality in patients over the age of 55 hospitalised in the ınternal medicine ntensive care unit from the emergency service. . 2013; 13 - 18.
Vancouver	ULUÖZ H,TOPAL Y,SEBE A,AY M,AÇIKALIN AKPINAR A,Gulen M,Acehan S The relationship between ınflammatory reagents and mortality in patients over the age of 55 hospitalised in the ınternal medicine ntensive care unit from the emergency service. . 2013; 13 - 18.
IEEE	ULUÖZ H,TOPAL Y,SEBE A,AY M,AÇIKALIN AKPINAR A,Gulen M,Acehan S "The relationship between ınflammatory reagents and mortality in patients over the age of 55 hospitalised in the ınternal medicine ntensive care unit from the emergency service." , ss.13 - 18, 2013.
ISNAD	ULUÖZ, Haşim Onur vd. "The relationship between ınflammatory reagents and mortality in patients over the age of 55 hospitalised in the ınternal medicine ntensive care unit from the emergency service". (2013), 13-18.

APA	ULUÖZ H, TOPAL Y, SEBE A, AY M, AÇIKALIN AKPINAR A, Gulen M, Acehan S (2013). The relationship between ınflammatory reagents and mortality in patients over the age of 55 hospitalised in the ınternal medicine ntensive care unit from the emergency service. Akademik Acil Tıp Dergisi, 12(1), 13 - 18.
Chicago	ULUÖZ Haşim Onur,TOPAL Yağmur,SEBE AHMET,AY Mehmet Oğuzhan,AÇIKALIN AKPINAR AYÇA,Gulen Muge,Acehan Selen The relationship between ınflammatory reagents and mortality in patients over the age of 55 hospitalised in the ınternal medicine ntensive care unit from the emergency service. Akademik Acil Tıp Dergisi 12, no.1 (2013): 13 - 18.
MLA	ULUÖZ Haşim Onur,TOPAL Yağmur,SEBE AHMET,AY Mehmet Oğuzhan,AÇIKALIN AKPINAR AYÇA,Gulen Muge,Acehan Selen The relationship between ınflammatory reagents and mortality in patients over the age of 55 hospitalised in the ınternal medicine ntensive care unit from the emergency service. Akademik Acil Tıp Dergisi, vol.12, no.1, 2013, ss.13 - 18.
AMA	ULUÖZ H,TOPAL Y,SEBE A,AY M,AÇIKALIN AKPINAR A,Gulen M,Acehan S The relationship between ınflammatory reagents and mortality in patients over the age of 55 hospitalised in the ınternal medicine ntensive care unit from the emergency service. Akademik Acil Tıp Dergisi. 2013; 12(1): 13 - 18.
Vancouver	ULUÖZ H,TOPAL Y,SEBE A,AY M,AÇIKALIN AKPINAR A,Gulen M,Acehan S The relationship between ınflammatory reagents and mortality in patients over the age of 55 hospitalised in the ınternal medicine ntensive care unit from the emergency service. Akademik Acil Tıp Dergisi. 2013; 12(1): 13 - 18.
IEEE	ULUÖZ H,TOPAL Y,SEBE A,AY M,AÇIKALIN AKPINAR A,Gulen M,Acehan S "The relationship between ınflammatory reagents and mortality in patients over the age of 55 hospitalised in the ınternal medicine ntensive care unit from the emergency service." Akademik Acil Tıp Dergisi, 12, ss.13 - 18, 2013.
ISNAD	ULUÖZ, Haşim Onur vd. "The relationship between ınflammatory reagents and mortality in patients over the age of 55 hospitalised in the ınternal medicine ntensive care unit from the emergency service". Akademik Acil Tıp Dergisi 12/1 (2013), 13-18.