The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma

ECEVİT, Cenk; Cetinayak, Hasan Oguz; AKMAN, Fadime; Onder, Devrim; Sarioglu, Sulen; İKİZ, Ahmet Ömer; ÜNLÜ, Şadiye Mehtat; Ada, Emel; KARAÇALI, BILGE

The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma

Şadiye Mehtat ÜNLÜ, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, İzmir, Türkiye)

Hasan Oğuz ÇETİNAYAK, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı, İzmir, Türkiye)

Devrim ÖNDER, (İzmir Yüksek Teknoloji Enstitüsü, Elektrik ve Elektronik Mühendisliği Bölümü, İzmir, Türkiye)

Cenk ECEVİT, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı, İzmir, Türkiye)

Fadime AKMAN, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı, İzmir, Türkiye)

Ahmet Ömer İKİZ, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı, İzmir, Türkiye)

Emel ADA, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Radiyoloji Anabilim Dalı, İzmir, Türkiye)

Bilge KARAÇALI, (İzmir Yüksek Teknoloji Enstitüsü, Elektrik ve Elektronik Mühendisliği Bölümü, İzmir, Türkiye)

Sülen SARIOĞLU (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, İzmir, Türkiye)

Türk Patoloji Dergisi

2 0

Yıl: 2013 Cilt: 29 Sayı: 1 Sayfa Aralığı: 27 - 35 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma

Öz:

Amaç: Tümör-stroma oranı bazı adenokarsinom tiplerinde kötü prognostik faktör olarak tanımlanmış olmakla birlikte skuamöz hücreli karsinomlarda ve özellikle de laringeal karsinomlarda tümör-stroma oranı ile ilgili araştırma bulunmamaktadır. Gereç ve Yöntem: Seksen beş larenjektomi materyalinin tümörü örnekleyen kesitlerinden 5 dijital görüntü kaydedildi. Tümör-stroma oranı bu görüntülerde bilgisayar programının 205,6 μm2 büyüklüğünde küçük kareler oluşturması ve patoloğun bilgisayar faresinde sol/sağ tıklama ile her bir alanı tümör ya da stroma olarak seçmesini sağlayan bir bilgisayar yazılım programı ile hesaplandı. Toplamda her olguda 16.785 tık ile 3.451 mm2 tümör alanı işaretlendi. Bulgular: Ortalama izlem 48 ay (3-194) ve ortalama tümör-stroma oranı 48,63±18,18 bulundu. Tümör yerleşimi, histolojik derecesi, evresi ve perinodal yayılım ile tümör-stroma oranları arasında anlamlı farklılık saptanmadı. İstatistiksel anlamlı sonuç elde edilmemiş olmakla birlikte ortalama tümör-stroma oranının en düşük izlendiği olgular subglottik yerleşimli olup ortalama oran 37,46±12,49 idi. Ortalama tümör-stroma oranı supraglottik olgularda 52,41±37,47, transglottik yerleşimde 50,86±19,84 ve glottik yerleşimde 44,56±16,91 olarak saptandı. Tümör-stroma oranı perinodal invazyon gösteren olgularda (44,72±20,23) düşük iken, perinodal invazyon bulunmayan (47,77±17,37) ve lenf nodu metastazı olmayanlarda 50,05±17,34 daha yüksek bulundu. Bazaloid skamoz hücreli karsinomlarda tümör-stroma oranı (53,76±14,70), klasik skuamöz hücreli karsinomdan (48,63±18,38) daha yüksek saptandı. Hastalıksız sağ kalım ve toplam sağ kalım ile tümör-stroma oranı arasında ilişki bulunmadı (p=0,08, p=0,38). Sadece patolojik evrenin prognostik bağımsız faktör olduğu saptandı (p=0,008). Sonuç: Bu çalışma yeni bir yöntem eşliğinde, laringeal karsinomlarda tümör-stroma oranının prognostik değerini araştıran ilk çalışmadır. Ancak bulgular tümör-stroma oranını prognostik bir belirleyici olarak desteklememektedir.

Anahtar Kelime:

Konular: Cerrahi

Laringeal skuamöz hücreli karsinomlarda tümör-stroma oranının prognostik değeri

Öz:

Objective: Tumor-stroma proportion of tumor has been presented as a prognostic factor in some types of adenocarcinomas, but there is no information about squamous cell carcinomas and laryngeal carcinomas. Material and Method: Five digital images of the tumor sections were obtained from 85 laryngeal carcinomas. Proportion of epithelial tumor component and stroma were measured by a software tool, allowing the pathologists to mark 205.6 μm2 blocks on areas as carcinomatous/stromal, by clicking at the image. Totally, 3.451 mm2 tumor areas have been marked to 16.785 small square blocks for each case. Results: Median follow up was 48 months (range 3-194). The mean tumor-stroma proportion was 48.63+18.18. There was no difference for tumor-stroma proportion when tumor location, grade, stage and perinodal invasion were considered. Although the following results were statistically insignificant, the mean tumor-stroma proportion was the lowest (37.46±12.49) for subglottic carcinomas, and it was 52.41±37.47, 50.86+19.84 and 44.56±16.91 for supraglottic, transglottic and glottic cases. The tumor-stroma proportion was lowest in cases with perinodal invasion and the highest in cases without lymph node metastasis (44.72±20.23, 47.77±17.37, 50.05±17.34). Tumor-stroma proportion was higher in the basaloid subtype compared with the classical squamous cell carcinoma (53.76±14.70 and 48.63±18.38 respectively). The overall and disease-free survival analysis did not reveal significance for tumor-stroma proportion (p=0.08, p=0.38). Only pathological stage was an independent factor for overall survival (p=0.008). Conclusion: This is the first series investigating tumor-stroma proportion as a prognostic marker in laryngeal carcinomas proposing a new method, but the findings do not support tumor-stroma proportion as a prognostic marker.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÜNLÜ Ş, Cetinayak H, Onder D, ECEVİT C, AKMAN F, İKİZ A, Ada E, KARAÇALI B, Sarioglu S (2013). The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma. , 27 - 35.
Chicago	ÜNLÜ Şadiye Mehtat,Cetinayak Hasan Oguz,Onder Devrim,ECEVİT Cenk,AKMAN Fadime,İKİZ Ahmet Ömer,Ada Emel,KARAÇALI BILGE,Sarioglu Sulen The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma. (2013): 27 - 35.
MLA	ÜNLÜ Şadiye Mehtat,Cetinayak Hasan Oguz,Onder Devrim,ECEVİT Cenk,AKMAN Fadime,İKİZ Ahmet Ömer,Ada Emel,KARAÇALI BILGE,Sarioglu Sulen The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma. , 2013, ss.27 - 35.
AMA	ÜNLÜ Ş,Cetinayak H,Onder D,ECEVİT C,AKMAN F,İKİZ A,Ada E,KARAÇALI B,Sarioglu S The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma. . 2013; 27 - 35.
Vancouver	ÜNLÜ Ş,Cetinayak H,Onder D,ECEVİT C,AKMAN F,İKİZ A,Ada E,KARAÇALI B,Sarioglu S The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma. . 2013; 27 - 35.
IEEE	ÜNLÜ Ş,Cetinayak H,Onder D,ECEVİT C,AKMAN F,İKİZ A,Ada E,KARAÇALI B,Sarioglu S "The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma." , ss.27 - 35, 2013.
ISNAD	ÜNLÜ, Şadiye Mehtat vd. "The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma". (2013), 27-35.

APA	ÜNLÜ Ş, Cetinayak H, Onder D, ECEVİT C, AKMAN F, İKİZ A, Ada E, KARAÇALI B, Sarioglu S (2013). The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma. Türk Patoloji Dergisi, 29(1), 27 - 35.
Chicago	ÜNLÜ Şadiye Mehtat,Cetinayak Hasan Oguz,Onder Devrim,ECEVİT Cenk,AKMAN Fadime,İKİZ Ahmet Ömer,Ada Emel,KARAÇALI BILGE,Sarioglu Sulen The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma. Türk Patoloji Dergisi 29, no.1 (2013): 27 - 35.
MLA	ÜNLÜ Şadiye Mehtat,Cetinayak Hasan Oguz,Onder Devrim,ECEVİT Cenk,AKMAN Fadime,İKİZ Ahmet Ömer,Ada Emel,KARAÇALI BILGE,Sarioglu Sulen The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma. Türk Patoloji Dergisi, vol.29, no.1, 2013, ss.27 - 35.
AMA	ÜNLÜ Ş,Cetinayak H,Onder D,ECEVİT C,AKMAN F,İKİZ A,Ada E,KARAÇALI B,Sarioglu S The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma. Türk Patoloji Dergisi. 2013; 29(1): 27 - 35.
Vancouver	ÜNLÜ Ş,Cetinayak H,Onder D,ECEVİT C,AKMAN F,İKİZ A,Ada E,KARAÇALI B,Sarioglu S The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma. Türk Patoloji Dergisi. 2013; 29(1): 27 - 35.
IEEE	ÜNLÜ Ş,Cetinayak H,Onder D,ECEVİT C,AKMAN F,İKİZ A,Ada E,KARAÇALI B,Sarioglu S "The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma." Türk Patoloji Dergisi, 29, ss.27 - 35, 2013.
ISNAD	ÜNLÜ, Şadiye Mehtat vd. "The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma". Türk Patoloji Dergisi 29/1 (2013), 27-35.