Large cell neuroendocrine carcinoma of urinary bladder; Case presentation
Yıl: 2013 Cilt: 29 Sayı: 2 Sayfa Aralığı: 138 - 142 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
Large cell neuroendocrine carcinoma of urinary bladder; Case presentation
Öz: Mesanenin büyük hücreli nöroendokrin tümörleri çok nadirdir. Bu tümörler küçük hücreli karsinomdan morfolojik olarak farklı olan ayrı bir nöroendokrin karsinom tipidir. Bu makalede 67 yaşında hematüri nedeniyle başvuran erkek olgu sunuldu. Ultrason tetkiki ve bilgisayarlı tomogrofide mesane sağ posterior-lateral duvarda yaklaşık 5 cm çapında perivezikal alanı infiltre eden kitle izlendi ve hastaya transüretral rezeksiyon uygulandı. Mikroskobik olarak tabakalar ve trabeküler tarzda büyüme gösteren, muskularis propriayı yaygın olarak invaze etmiş arada nekroz odakları içeren tümör izlendi. Tümör hücreleri kaba kromatinli, belirgin nükleollu, kısmen bol sitoplazmalı olup immunohistokimyasal olarak sinaptofizin, kromogranin, ve CD56 ile kuvvetli pozitif idi. Mesanenin Büyük Hücreli Nöroendokrin Karsinomuna ait çok az sayıda olgu rapor edildiğinden, bu tümörlerin biyolojik davranışları ve tedavi protokolleri henüz belirsizdir. Rapor edilen olgu sayısının artması uygun tedavi protokollerinin geliştirilmesine ve prognozlarının tahmin edilmesine katkı sağlayacağından mesanede kötü diferansiye bir tümör varlığında, nadir olarak izlense de büyük hücreli nöroendokrin karsinomu akılda tutmak önem kazanmaktadır.
Anahtar Kelime: Konular:
Mesanenin büyük hücreli nöroendokrin karsinomu; Olgu sunumu
Öz: Large cell neuroendocrine tumor of the urinary bladder is very rare. It is a type of neuroendocrine carcinoma that is morphologically different from small cell carcinoma. This manuscript describes a 67-year-old man who presented with hematuria. Ultrasonogrophic and computer tomography revealed a 5 cm mass in right posterolateral wall of the bladder that invaded perivesical tissue and he subsequently underwent transurethral resection. Microscopic examination showed a tumor with a sheet-like and trabecular growth pattern comprising necrotic areas which infiltrated the muscularis propria. Tumoral cells had coarse chromatin, prominent nucleoli, moderate amount of cytoplasm and immunohistochemically stained strongly positive with synaptophysin, chromogranin and CD56. There are only few case reports of large cell neuroendocrine tumor of the urinary bladder so the biological behavior and the treatment protocol of these tumors are still obscure. Appropriate management protocols and prognostic estimation could be achived by the increased number of cases being reported. Therefore in a case of a poorly differentiated tumor in bladder, although rare, it is important to consider large cell neuroendocrine carcinoma in differential diagnosis.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
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| APA | SARI A, ERMETE M, SADULLAHOĞLU C, BAL K, BÖLÜKBAŞI A (2013). Large cell neuroendocrine carcinoma of urinary bladder; Case presentation. , 138 - 142. |
| Chicago | SARI Ayşegül,ERMETE Murat,SADULLAHOĞLU CANAN,BAL Kaan,BÖLÜKBAŞI Ahmet Large cell neuroendocrine carcinoma of urinary bladder; Case presentation. (2013): 138 - 142. |
| MLA | SARI Ayşegül,ERMETE Murat,SADULLAHOĞLU CANAN,BAL Kaan,BÖLÜKBAŞI Ahmet Large cell neuroendocrine carcinoma of urinary bladder; Case presentation. , 2013, ss.138 - 142. |
| AMA | SARI A,ERMETE M,SADULLAHOĞLU C,BAL K,BÖLÜKBAŞI A Large cell neuroendocrine carcinoma of urinary bladder; Case presentation. . 2013; 138 - 142. |
| Vancouver | SARI A,ERMETE M,SADULLAHOĞLU C,BAL K,BÖLÜKBAŞI A Large cell neuroendocrine carcinoma of urinary bladder; Case presentation. . 2013; 138 - 142. |
| IEEE | SARI A,ERMETE M,SADULLAHOĞLU C,BAL K,BÖLÜKBAŞI A "Large cell neuroendocrine carcinoma of urinary bladder; Case presentation." , ss.138 - 142, 2013. |
| ISNAD | SARI, Ayşegül vd. "Large cell neuroendocrine carcinoma of urinary bladder; Case presentation". (2013), 138-142. |
| APA | SARI A, ERMETE M, SADULLAHOĞLU C, BAL K, BÖLÜKBAŞI A (2013). Large cell neuroendocrine carcinoma of urinary bladder; Case presentation. Türk Patoloji Dergisi, 29(2), 138 - 142. |
| Chicago | SARI Ayşegül,ERMETE Murat,SADULLAHOĞLU CANAN,BAL Kaan,BÖLÜKBAŞI Ahmet Large cell neuroendocrine carcinoma of urinary bladder; Case presentation. Türk Patoloji Dergisi 29, no.2 (2013): 138 - 142. |
| MLA | SARI Ayşegül,ERMETE Murat,SADULLAHOĞLU CANAN,BAL Kaan,BÖLÜKBAŞI Ahmet Large cell neuroendocrine carcinoma of urinary bladder; Case presentation. Türk Patoloji Dergisi, vol.29, no.2, 2013, ss.138 - 142. |
| AMA | SARI A,ERMETE M,SADULLAHOĞLU C,BAL K,BÖLÜKBAŞI A Large cell neuroendocrine carcinoma of urinary bladder; Case presentation. Türk Patoloji Dergisi. 2013; 29(2): 138 - 142. |
| Vancouver | SARI A,ERMETE M,SADULLAHOĞLU C,BAL K,BÖLÜKBAŞI A Large cell neuroendocrine carcinoma of urinary bladder; Case presentation. Türk Patoloji Dergisi. 2013; 29(2): 138 - 142. |
| IEEE | SARI A,ERMETE M,SADULLAHOĞLU C,BAL K,BÖLÜKBAŞI A "Large cell neuroendocrine carcinoma of urinary bladder; Case presentation." Türk Patoloji Dergisi, 29, ss.138 - 142, 2013. |
| ISNAD | SARI, Ayşegül vd. "Large cell neuroendocrine carcinoma of urinary bladder; Case presentation". Türk Patoloji Dergisi 29/2 (2013), 138-142. |
