HPV types in Turkey: Multicenter hospital Based evaluation of 6388 patients in Turkish gynecologic oncology group centers

Amaç:Türkiyedeki HPV tiplerinin geniş bir seri ile ortaya konması amacı ile Türk Jinekolojik Onkoloji grubuna üye hastanelerde HPV analizi yapılan hastaların sonuçlarının retrospektif olarak değerlendirilmesi ve sitolojik anormalliklerdeki HPV tiplerinin belirlenmesi.Gereç ve Yöntem:2006 ve 2010 yılları arasında 12 ayrı merkeze başvuran smear ve HPV analizi yapılan toplam 6388 hasta retrospektif olarak incelenmiştir. Hastaların demografik bilgileri, smear sonuçları, HPV tipleri online olarak toplanıp analiz edilmiştir. Bulgular:Ortalama hasta yaşı 38.9±10.2 idi. Tüm grup değerlendiril- diğinde, %25 hastada HPV pozitif olarak saptandı. Anormal sitolojisi olanlarda HPV pozitifliği %57 iken normal pap testi olanlarda HPV pozitifliği %27 oranında tespit edildi.Hastaların yaşam dekadları ile HPV pozitifliği arasında anlamlı bir ilişki bulundu (p<0,05) HPV pozitifliği ASCUS, ASC-H, LSIL, HSIL, glandüler anormallikler ve skuamöz hücreli karsinom için sırasıyla %37, %9, %27, %20, %22, %41 idi. En sık görülen HPV tipleri sırasıyla HPV 16 (%32), HPV 6 (%17), HPV 11 (%9), HPV 18 (%8), HPV 31 (%6), HPV 51 (%5), HPV 33 (%3) idi. Sonuç:Bu hastane temelli retrospektif analizde HPV tipleri gelişmiş batı ülkelerinde rapor edilen tiplerle benzer olarak tespit edildi. Ülkemizdeki gerçek popülasyon temelli HPV prevalansı ve tiplerinin belirlenmesi için hastane temelli olmayan çok merkezli geniş sayıda hasta içeren serilere ihtiyaç vardır

Anahtar Kelime:

Konular: Cerrahi

Türkiye’deki hpv tipleri: Türk jinekolojik onkoloji grubuna üye merkezlere başvuran 6388 hastanın retrospektif analizi

Öz:

Objective:To evaluate the prevalence of HPV DNA and cervical cytological abnormalities, to compare cervical cytology results and HPV DNA and to define HPV types distribution in a large series of Turkish women who have undergone HPV analysis in hospitals that are members of the Turkish Gynecological Oncology Group. Material and Method:Between 2006 and 2010, a total of 6388 patients’ data was retrospectively evaluated at 12 healthcare centers in Turkey. Demographic characteristics, cervical cytology results, HPV status and types were compared.Results:The mean age of the patients was 38.9±10.2. Overall, 25% of the women were found to be HPV positive. Presence of HPV-DNA among patients with abnormal and normal cytology was 52% and 27%, respectively. There was significant diff erence with respect to decades of life and HPV positivity (p < 0.05). HPV was positive in(within the HPV (+) patients) 37%, 9%, 27%, 20%, 22%, and 41% of the ASCUS, ASC-H, LSIL HSIL, glandular cell abnormalities, and SCC cases respectively The most common HPV types in our study were as follows; HPV 16 (32%), HPV 6 (17%), HPV 11 (9%), HPV 18 (8%), HPV 31 (6%), HPV 51 (5%), HPV 33 (3%). Conclusion:In this hospital based retrospective analysis, HPV genotypes in Turkish women with normal and abnormal cytology are similar to those reported from western countries. Further population based prospective multicenter studies are necessary to determine non-hospital based HPV prev alence in Turkish women

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1.Armstrong EP:Prophylaxis of cervical cancer and related cervical disease: A review of the cost-effectiveness of vaccination against oncogenic HPV types. Journal of Managed Care Pharmacy 2010, 16: 217–230
2. World Health Organization (February 2006). Fact sheet No. 297: Cancer. Retrieved 2007-12-01
3. GLOBOCAN 2002 [database online]: Summary table by cancer. Archived from the original on 2008-06-16. Retrieved 2008-10-26
4. NCCC National Cervical Cancer Coalition. Archived from the original on 2008-08-22. Retrieved 2008-07-01
5.Canavan TP, Doshi NR:Cervical cancer. Am Fam Physician 2000, 61: 1369–1376
6.Dursun P, Senger SS, Arslan H, Kuşçu E, Ayhan A:Human papillomavirus (HPV) prevalence and types among Turkish women at a gynecology outpatient unit. BMC Infect Dis 2009, 9:191
7.Solomon D, Davey D, Kurman R, Moriarty A, O’Connor D, Prey M, Raab S, Sherman M, Wilbur D, Wright T Jr, Young N; Forum Group Members; Bethesda 2001 Workshop: The 2001 Bethesda System: Terminology for reporting results of cervical cytology. JAMA 2002, 287:2114–2119
8.Evans MF, Adamson CS, Papillo JL, St John TL, Leiman G, Cooper K:Distribution of human papillomavirus types in thinprep papanicolaou tests classifi ed according to the Bethesda 2001 terminology and correlations with patient age and biopsy outcomes. Cancer 2006, 106:1054-1064
9. World Health Organization, Human papillomaviruses Interna- tional Agency for Research on Cancer 2007. ISBN 978-92-832- 1290-4
10.Marrazzo JM, Koutsky LA, Kiviat NB, Kuypers JM, Stine K: Papanicolaou test screening and prevalence of genital human papillomavirus among women who have sex with women. Am J Public Health 2001, 91: 947–952
11.Muñoz N, Bosch FX, de Sanjosé S, Herrero R, Castellsagué X, Shah KV, Snijders PJ, Meijer CJ: Epidemiologic classifi cation of human papillomavirus types associated with cervical cancer. N Engl J Med 2003, 348: 518–527
12.Inal MM, Köse S, Yildirim Y, Ozdemir Y, Töz E, Ertopçu K, Ozelmas I, Tinar S:The relationship between human papillomavirus infection and cervical intraepithelial neoplasia in Turkish women. Int J Gynecol Cancer 2007, 7:1266-1270
13. Ozcelik B, Serin IS, Gokahmetoglu S, Basbug M, Erez R: Human papillomavirus frequency of women at low risk of developing cervical cancer: A preliminary study from a Turkish university hospital. Eur J Gynaecol Oncol 2003, 24:157-159
14.Tuncer ZS, Basaran M, Ustaçelebi S, Kuzey GM: High-Risk Human Papilloma Virus (HPV) Infection Determined By Hybrid Capture II Assay in a Turkish University Hospital Outpatient. Clinic MN-Gorm 2006, 12:129-134
15.Seçkin S, Aksoy F, Yıldırım M:Servikal smearlerde HPV infeksiyonu görülme indisansı. Ankara Numune Eğitim ve Arastırma Hastanesi Tıp Dergisi 1996, 36:101-103
16.Safi Z, Demirezen S, Beksaç MS, Kuzey GM, Kocagöz T, Ustaçelebi Ş, Hasçelik G, Çakar An: İnsan papilloma virüsünün (IPV) polimeraz zincir reaksiyonu tek niği ile servikal ve vajinal akıntı örneklerinde saptanması. MN-Klinik Bilimler&Doktor 2002, 8:112-114
17.Bao YP, Li N, Smith JS, Qiao YL, ACCPAB: Human papillomavirus type distribution in women from Asia: A meta- analysis. Int J Gynecol Cancer 2008, 18:71-79
18.de Sanjosé S, Diaz M, Castellsagué X, Cliff ord G, Bruni L, Muñoz N, Bosch FX: Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: A meta-analysis. Lancet Infect Dis 2007, 7:453-459
19.Cliff ord GM, Gallus S, Herrero R, Muñoz N, Snijders PJ, Vaccarella S, Anh PT, Ferreccio C, Hieu NT, Matos E, Molano M, Rajkumar R, Ronco G, de Sanjosé S, Shin HR, Sukvirach S, Th omas JO, Tunsakul S, Meijer CJ, Franceschi S; IARC HPV Prevalence Surveys Study Group: Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: A pooled analysis. Lancet 2005, 366:991-998
20.Usubütün A, Alemany L, Küçükali T, Ayhan A, Yüce K, de Sanjosé S, Font R, Lloveras B, Klaustermeier J, Quint W, Muñoz N, Bosch FX: Human papillomavirus types in invasive cervical cancer specimens from Turkey. Int J Gynecol Pathol 2009, 28:541-548
21.Rowe LR, Aldeen W, Bentz JS:Prevalence and typing of HPV by hybrid capture in women with ASCUS, ASC-H and AGC on ThinPrep Pap test. Diagn Cytopathol 2004, 30:426-432
22.González-Bosquet E, Esteva C, Muñoz-Almagro C, Ferrer P, Pérez M, Lailla JM: Identifi cation of vaccine human papillomavirus genotypes in squamous intraepithelial lesions (CIN2-3). Gynecol Oncol 2008, 111:9-12
23.Levert M, Clavel C, Graesslin O, Masure M, Birembaut P, Quereux C, Gabriel R: Human papillomavirus typing in routine cervical smears. Result from a series of 3778 patients. Gynecol Obstet Fertil 2000, 28:722-728
24.Hwang HS, Park M, Lee SY, Kwon KH, Pang MG: Distribution and Prevalence of Human Papillomavirus Genotypes in Routine Pap Smear of 2,470 Korean Women Determined by DNA Chip. Cancer Epidemiol Biomarkers Prev 2004, 13:2153-2156
25.Burk RD, Kelly P, Feldman J, Bromberg J, Vermund SH, DeHovitz JA, Landesman SH: Declining prevalence of cervi- covaginal human papillomavirus infection with age is inde- pendent of other risk factors. Sex Transm Dis 1996, 23:333-341
26. Prevalence of Abnormal Cervical Cytology in Turkey: A Turkish Gynecologic Oncology Group study. Turkish Cervical Cancer and Cervical Cytology Research Group. Int J Gynaecol Obstet 2009, 106:206-209
27.Sellors JW, Mahony JB, Kaczorowski J, Lytwyn A, Bangura H, Chong S, Lorincz A, Dalby DM, Janjusevic V, Keller JL: Prevalence and pre- dictors of human papilloma virus infection in women in Ontario, Canada. Survey of HPV in Ontario Women (SHOW) Group. CMAJ 2000, 163:503-508

APA	DURSUN P, Ayhan A, MUTLU L, Çağlar M, HABERAL A, GÜNGÖR T, ÖZAT M, ÖZGÜ E, ONAN M, TAŞKIRAN Ç, GÜNER H, YETİMALAR H, Kasap B, Yuce K, SALMAN M, SAYAL B, DOĞAN S, Harma M, HARMA M, BAŞARAN M, aydogmus h, ERGÜN Y, ŞEHİRALİ S, GÜLTEKİN E, köse ş, Yıldırım Y, Alanbay İ, KARACA R, METİNDİR J, Keskin H, ÜSTÜNER I, AVŞAR F, Yüksel H, KIRDAR S, Dede O, YENEN M (2013). HPV types in Turkey: Multicenter hospital Based evaluation of 6388 patients in Turkish gynecologic oncology group centers. , 210 - 216.
Chicago	DURSUN Polat,Ayhan Ali,MUTLU Levent,Çağlar Mete,HABERAL Ali,GÜNGÖR Taygun,ÖZAT Mustafa,ÖZGÜ Emre,ONAN MEHMET ANIL,TAŞKIRAN Çağatay,GÜNER Haldun,YETİMALAR Hakan,Kasap Burcu,Yuce Kunter,SALMAN M. Coşkun,SAYAL Berkan,DOĞAN SELEN,Harma Müge,HARMA Mehmet,BAŞARAN Mustafa,aydogmus huseyin,ERGÜN Yusuf,ŞEHİRALİ Salim,GÜLTEKİN Emre,köse şükran,Yıldırım Yusuf,Alanbay İbrahim,KARACA Rıza,METİNDİR Jale,Keskin Huseyin Levent,ÜSTÜNER Işık,AVŞAR Filiz,Yüksel Hasan,KIRDAR Selim,Dede Okan Murat,YENEN Müfit C. HPV types in Turkey: Multicenter hospital Based evaluation of 6388 patients in Turkish gynecologic oncology group centers. (2013): 210 - 216.
MLA	DURSUN Polat,Ayhan Ali,MUTLU Levent,Çağlar Mete,HABERAL Ali,GÜNGÖR Taygun,ÖZAT Mustafa,ÖZGÜ Emre,ONAN MEHMET ANIL,TAŞKIRAN Çağatay,GÜNER Haldun,YETİMALAR Hakan,Kasap Burcu,Yuce Kunter,SALMAN M. Coşkun,SAYAL Berkan,DOĞAN SELEN,Harma Müge,HARMA Mehmet,BAŞARAN Mustafa,aydogmus huseyin,ERGÜN Yusuf,ŞEHİRALİ Salim,GÜLTEKİN Emre,köse şükran,Yıldırım Yusuf,Alanbay İbrahim,KARACA Rıza,METİNDİR Jale,Keskin Huseyin Levent,ÜSTÜNER Işık,AVŞAR Filiz,Yüksel Hasan,KIRDAR Selim,Dede Okan Murat,YENEN Müfit C. HPV types in Turkey: Multicenter hospital Based evaluation of 6388 patients in Turkish gynecologic oncology group centers. , 2013, ss.210 - 216.
AMA	DURSUN P,Ayhan A,MUTLU L,Çağlar M,HABERAL A,GÜNGÖR T,ÖZAT M,ÖZGÜ E,ONAN M,TAŞKIRAN Ç,GÜNER H,YETİMALAR H,Kasap B,Yuce K,SALMAN M,SAYAL B,DOĞAN S,Harma M,HARMA M,BAŞARAN M,aydogmus h,ERGÜN Y,ŞEHİRALİ S,GÜLTEKİN E,köse ş,Yıldırım Y,Alanbay İ,KARACA R,METİNDİR J,Keskin H,ÜSTÜNER I,AVŞAR F,Yüksel H,KIRDAR S,Dede O,YENEN M HPV types in Turkey: Multicenter hospital Based evaluation of 6388 patients in Turkish gynecologic oncology group centers. . 2013; 210 - 216.
Vancouver	DURSUN P,Ayhan A,MUTLU L,Çağlar M,HABERAL A,GÜNGÖR T,ÖZAT M,ÖZGÜ E,ONAN M,TAŞKIRAN Ç,GÜNER H,YETİMALAR H,Kasap B,Yuce K,SALMAN M,SAYAL B,DOĞAN S,Harma M,HARMA M,BAŞARAN M,aydogmus h,ERGÜN Y,ŞEHİRALİ S,GÜLTEKİN E,köse ş,Yıldırım Y,Alanbay İ,KARACA R,METİNDİR J,Keskin H,ÜSTÜNER I,AVŞAR F,Yüksel H,KIRDAR S,Dede O,YENEN M HPV types in Turkey: Multicenter hospital Based evaluation of 6388 patients in Turkish gynecologic oncology group centers. . 2013; 210 - 216.
IEEE	DURSUN P,Ayhan A,MUTLU L,Çağlar M,HABERAL A,GÜNGÖR T,ÖZAT M,ÖZGÜ E,ONAN M,TAŞKIRAN Ç,GÜNER H,YETİMALAR H,Kasap B,Yuce K,SALMAN M,SAYAL B,DOĞAN S,Harma M,HARMA M,BAŞARAN M,aydogmus h,ERGÜN Y,ŞEHİRALİ S,GÜLTEKİN E,köse ş,Yıldırım Y,Alanbay İ,KARACA R,METİNDİR J,Keskin H,ÜSTÜNER I,AVŞAR F,Yüksel H,KIRDAR S,Dede O,YENEN M "HPV types in Turkey: Multicenter hospital Based evaluation of 6388 patients in Turkish gynecologic oncology group centers." , ss.210 - 216, 2013.
ISNAD	DURSUN, Polat vd. "HPV types in Turkey: Multicenter hospital Based evaluation of 6388 patients in Turkish gynecologic oncology group centers". (2013), 210-216.

APA	DURSUN P, Ayhan A, MUTLU L, Çağlar M, HABERAL A, GÜNGÖR T, ÖZAT M, ÖZGÜ E, ONAN M, TAŞKIRAN Ç, GÜNER H, YETİMALAR H, Kasap B, Yuce K, SALMAN M, SAYAL B, DOĞAN S, Harma M, HARMA M, BAŞARAN M, aydogmus h, ERGÜN Y, ŞEHİRALİ S, GÜLTEKİN E, köse ş, Yıldırım Y, Alanbay İ, KARACA R, METİNDİR J, Keskin H, ÜSTÜNER I, AVŞAR F, Yüksel H, KIRDAR S, Dede O, YENEN M (2013). HPV types in Turkey: Multicenter hospital Based evaluation of 6388 patients in Turkish gynecologic oncology group centers. Türk Patoloji Dergisi, 29(3), 210 - 216.
Chicago	DURSUN Polat,Ayhan Ali,MUTLU Levent,Çağlar Mete,HABERAL Ali,GÜNGÖR Taygun,ÖZAT Mustafa,ÖZGÜ Emre,ONAN MEHMET ANIL,TAŞKIRAN Çağatay,GÜNER Haldun,YETİMALAR Hakan,Kasap Burcu,Yuce Kunter,SALMAN M. Coşkun,SAYAL Berkan,DOĞAN SELEN,Harma Müge,HARMA Mehmet,BAŞARAN Mustafa,aydogmus huseyin,ERGÜN Yusuf,ŞEHİRALİ Salim,GÜLTEKİN Emre,köse şükran,Yıldırım Yusuf,Alanbay İbrahim,KARACA Rıza,METİNDİR Jale,Keskin Huseyin Levent,ÜSTÜNER Işık,AVŞAR Filiz,Yüksel Hasan,KIRDAR Selim,Dede Okan Murat,YENEN Müfit C. HPV types in Turkey: Multicenter hospital Based evaluation of 6388 patients in Turkish gynecologic oncology group centers. Türk Patoloji Dergisi 29, no.3 (2013): 210 - 216.
MLA	DURSUN Polat,Ayhan Ali,MUTLU Levent,Çağlar Mete,HABERAL Ali,GÜNGÖR Taygun,ÖZAT Mustafa,ÖZGÜ Emre,ONAN MEHMET ANIL,TAŞKIRAN Çağatay,GÜNER Haldun,YETİMALAR Hakan,Kasap Burcu,Yuce Kunter,SALMAN M. Coşkun,SAYAL Berkan,DOĞAN SELEN,Harma Müge,HARMA Mehmet,BAŞARAN Mustafa,aydogmus huseyin,ERGÜN Yusuf,ŞEHİRALİ Salim,GÜLTEKİN Emre,köse şükran,Yıldırım Yusuf,Alanbay İbrahim,KARACA Rıza,METİNDİR Jale,Keskin Huseyin Levent,ÜSTÜNER Işık,AVŞAR Filiz,Yüksel Hasan,KIRDAR Selim,Dede Okan Murat,YENEN Müfit C. HPV types in Turkey: Multicenter hospital Based evaluation of 6388 patients in Turkish gynecologic oncology group centers. Türk Patoloji Dergisi, vol.29, no.3, 2013, ss.210 - 216.
AMA	DURSUN P,Ayhan A,MUTLU L,Çağlar M,HABERAL A,GÜNGÖR T,ÖZAT M,ÖZGÜ E,ONAN M,TAŞKIRAN Ç,GÜNER H,YETİMALAR H,Kasap B,Yuce K,SALMAN M,SAYAL B,DOĞAN S,Harma M,HARMA M,BAŞARAN M,aydogmus h,ERGÜN Y,ŞEHİRALİ S,GÜLTEKİN E,köse ş,Yıldırım Y,Alanbay İ,KARACA R,METİNDİR J,Keskin H,ÜSTÜNER I,AVŞAR F,Yüksel H,KIRDAR S,Dede O,YENEN M HPV types in Turkey: Multicenter hospital Based evaluation of 6388 patients in Turkish gynecologic oncology group centers. Türk Patoloji Dergisi. 2013; 29(3): 210 - 216.
Vancouver	DURSUN P,Ayhan A,MUTLU L,Çağlar M,HABERAL A,GÜNGÖR T,ÖZAT M,ÖZGÜ E,ONAN M,TAŞKIRAN Ç,GÜNER H,YETİMALAR H,Kasap B,Yuce K,SALMAN M,SAYAL B,DOĞAN S,Harma M,HARMA M,BAŞARAN M,aydogmus h,ERGÜN Y,ŞEHİRALİ S,GÜLTEKİN E,köse ş,Yıldırım Y,Alanbay İ,KARACA R,METİNDİR J,Keskin H,ÜSTÜNER I,AVŞAR F,Yüksel H,KIRDAR S,Dede O,YENEN M HPV types in Turkey: Multicenter hospital Based evaluation of 6388 patients in Turkish gynecologic oncology group centers. Türk Patoloji Dergisi. 2013; 29(3): 210 - 216.
IEEE	DURSUN P,Ayhan A,MUTLU L,Çağlar M,HABERAL A,GÜNGÖR T,ÖZAT M,ÖZGÜ E,ONAN M,TAŞKIRAN Ç,GÜNER H,YETİMALAR H,Kasap B,Yuce K,SALMAN M,SAYAL B,DOĞAN S,Harma M,HARMA M,BAŞARAN M,aydogmus h,ERGÜN Y,ŞEHİRALİ S,GÜLTEKİN E,köse ş,Yıldırım Y,Alanbay İ,KARACA R,METİNDİR J,Keskin H,ÜSTÜNER I,AVŞAR F,Yüksel H,KIRDAR S,Dede O,YENEN M "HPV types in Turkey: Multicenter hospital Based evaluation of 6388 patients in Turkish gynecologic oncology group centers." Türk Patoloji Dergisi, 29, ss.210 - 216, 2013.
ISNAD	DURSUN, Polat vd. "HPV types in Turkey: Multicenter hospital Based evaluation of 6388 patients in Turkish gynecologic oncology group centers". Türk Patoloji Dergisi 29/3 (2013), 210-216.