Cardiac iron load and novel p-wave measurements in patients with thalassemia major The role of P index and Interatrial Block

KAYRAK, Mehmet; ABDULHALIKOV, Turyan; Acar, Kadir; Gul, Enes; ÖZBEK, Orhan; UÇAR, Ramazan

Cardiac iron load and novel p-wave measurements in patients with thalassemia major The role of P index and Interatrial Block

Kadir ACAR, (Gazi Üniversitesi, Tıp Fakültesi, Hematoloji Anabilim Dalı, Ankara, Türkiye)

Mehmet KAYRAK, (Konya Üniversitesi, Meram Tıp Fakültesi, Kardiyoloji Kliniği, Konya, Türkiye)

Enes Elvin GÜL, (Konya Üniversitesi, Meram Tıp Fakültesi, Kardiyoloji Kliniği, Konya, Türkiye)

Turyan ABDULHALIKOV, (Konya Üniversitesi, Meram Tıp Fakültesi, Kardiyoloji Kliniği, Konya, Türkiye)

Orhan ÖZBEK, (Konya Üniversitesi, Meram Tıp Fakültesi, Radyoloji Anabilim Dalı, Konya, Türkiye)

Ramazan UÇAR (Konya Üniversitesi, Meram Tıp Fakültesi,İç Hastalıkları Anabilim Dalı, Konya, Türkiye)

European Journal of General Medicine

1 1

Yıl: 2012 Cilt: 9 Sayı: 1 Sayfa Aralığı: 45 - 51 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Cardiac iron load and novel p-wave measurements in patients with thalassemia major The role of P index and Interatrial Block

Öz:

Kalpteki demir yükünün ventriküler repolarizasyon üzerindeki olumsuz etkileri beta-talasemi hastalarında gösterilmiştir. Fakat atriyal fibrilasyon (AF) gelişiminin bağımsız risk faktörleri olan P-dalga parametreleri ile ilgili beta talasemili hastalarda kısıtlı bilgi vardır. Bu nedenle biz asemptomatik beta talasemili hastalarda P-dalga parametreleri ile magnetic rezonans görüntülemede (MRG) elde edilen demir yükü arasındaki ilişkiyi araştırmayı amaçladık.Çalışmaya 22 β-TM hastaları ve yaş ve cinsiyetle uyumlu olan 22 sağlıklı kontrol dahil edildi. P max, P min, and Pi β-TM grupta sağlıklı kontrole gore anlamlı derecede yüksek tespit edildi (p=0.005, p=0.01, and p=0.03, sırasıyla). Pd gruplar arasında benzer bulundu (p=0.46). Kısmı IAB prevalansı β-TM hastalarında artmış bulundu ve komplet IAB sadece bir hastada görüldü P-dalga parametreleri kardiyak T2*<20 msan and T2*>=20 msan olan hastalarda benzer bulundu. P-dalga parametreleri ile kardiyak T2* MRG değerleri arasında anlamlı korelasyon izlenmedi. Bu çalışma gösterdi ki, P-dalga parametreleri sol ventrikül fonksiyonları korunmuş olan β-TM hastalarında kısmen etkilenmiştir ve bu bozulma kardiyak demir yükü ile ilişkili değildir. Sonuç olarak, β-TMnin AF gelişmesindeki rolü halen tartışmalıdır.

Anahtar Kelime:

Konular: Cerrahi

Kalpteki demir yükü ve talesemi majör hastalarında yeni p-dalga ölçümleri

Öz:

The deleterious effects of cardiac iron load on the ventricular repolarization were demonstrated in beta-thalassemia major (β- TM), but little is known about the P wave measurements, an independent risk factor for development of atrial fibrillation (AF). We aimed to examine relationship between P-wave parameters and iron loading using cardiac T2* Magnetic Resonance Imaging (MRI) in asymptomatic β-TM patients. The study involved 22 β-TM patients and 22 age- and gender-matched healthy controls. Although P-wave parameters were within normal limits, P max, P min, and Pi were significantly prolonged in the β-TM group compared to the healthy controls (p=0.005, p=0.01, and p=0.03, respectively). Pd was found similar between groups (p=0.46). The prevalence of partial IAB was increased in patients with β-TM (p=0.001) and complete IAB was detected only in one patient. P-wave param- eters of patients with cardiac T2*<20 msec and T2*>=20 msec were comparable in patients with β-TM. There was no correlation between P-wave parameters and cardiac T2*MRI values. The present study demonstrated that P-wave measurements were slightly affected in β-TM patients with preserved LV functions and this influence was not related with cardiac T2*MRI values. We concluded that the effect of β-TM on the AF development is still controversial.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Acar K, KAYRAK M, Gul E, ABDULHALIKOV T, ÖZBEK O, UÇAR R (2012). Cardiac iron load and novel p-wave measurements in patients with thalassemia major The role of P index and Interatrial Block. , 45 - 51.
Chicago	Acar Kadir,KAYRAK Mehmet,Gul Enes,ABDULHALIKOV Turyan,ÖZBEK Orhan,UÇAR Ramazan Cardiac iron load and novel p-wave measurements in patients with thalassemia major The role of P index and Interatrial Block. (2012): 45 - 51.
MLA	Acar Kadir,KAYRAK Mehmet,Gul Enes,ABDULHALIKOV Turyan,ÖZBEK Orhan,UÇAR Ramazan Cardiac iron load and novel p-wave measurements in patients with thalassemia major The role of P index and Interatrial Block. , 2012, ss.45 - 51.
AMA	Acar K,KAYRAK M,Gul E,ABDULHALIKOV T,ÖZBEK O,UÇAR R Cardiac iron load and novel p-wave measurements in patients with thalassemia major The role of P index and Interatrial Block. . 2012; 45 - 51.
Vancouver	Acar K,KAYRAK M,Gul E,ABDULHALIKOV T,ÖZBEK O,UÇAR R Cardiac iron load and novel p-wave measurements in patients with thalassemia major The role of P index and Interatrial Block. . 2012; 45 - 51.
IEEE	Acar K,KAYRAK M,Gul E,ABDULHALIKOV T,ÖZBEK O,UÇAR R "Cardiac iron load and novel p-wave measurements in patients with thalassemia major The role of P index and Interatrial Block." , ss.45 - 51, 2012.
ISNAD	Acar, Kadir vd. "Cardiac iron load and novel p-wave measurements in patients with thalassemia major The role of P index and Interatrial Block". (2012), 45-51.

APA	Acar K, KAYRAK M, Gul E, ABDULHALIKOV T, ÖZBEK O, UÇAR R (2012). Cardiac iron load and novel p-wave measurements in patients with thalassemia major The role of P index and Interatrial Block. European Journal of General Medicine, 9(1), 45 - 51.
Chicago	Acar Kadir,KAYRAK Mehmet,Gul Enes,ABDULHALIKOV Turyan,ÖZBEK Orhan,UÇAR Ramazan Cardiac iron load and novel p-wave measurements in patients with thalassemia major The role of P index and Interatrial Block. European Journal of General Medicine 9, no.1 (2012): 45 - 51.
MLA	Acar Kadir,KAYRAK Mehmet,Gul Enes,ABDULHALIKOV Turyan,ÖZBEK Orhan,UÇAR Ramazan Cardiac iron load and novel p-wave measurements in patients with thalassemia major The role of P index and Interatrial Block. European Journal of General Medicine, vol.9, no.1, 2012, ss.45 - 51.
AMA	Acar K,KAYRAK M,Gul E,ABDULHALIKOV T,ÖZBEK O,UÇAR R Cardiac iron load and novel p-wave measurements in patients with thalassemia major The role of P index and Interatrial Block. European Journal of General Medicine. 2012; 9(1): 45 - 51.
Vancouver	Acar K,KAYRAK M,Gul E,ABDULHALIKOV T,ÖZBEK O,UÇAR R Cardiac iron load and novel p-wave measurements in patients with thalassemia major The role of P index and Interatrial Block. European Journal of General Medicine. 2012; 9(1): 45 - 51.
IEEE	Acar K,KAYRAK M,Gul E,ABDULHALIKOV T,ÖZBEK O,UÇAR R "Cardiac iron load and novel p-wave measurements in patients with thalassemia major The role of P index and Interatrial Block." European Journal of General Medicine, 9, ss.45 - 51, 2012.
ISNAD	Acar, Kadir vd. "Cardiac iron load and novel p-wave measurements in patients with thalassemia major The role of P index and Interatrial Block". European Journal of General Medicine 9/1 (2012), 45-51.