Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor

Meryem TOPAL, (Atatürk Üniversitesi, Fen Fakültesi, Kimya Bölümü, Erzurum, Türkiye)
İlhami GÜLÇİN (Department of Zoology, College of Science, King Saud University, Riyadh, Saudi, Arabia)
Turkish Journal of Chemistry
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Yıl: 2014 Cilt: 38 Sayı: 5 Sayfa Aralığı: 894 - 902 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor

Öz:
Rosmarinic acid is a water-soluble ester of caffeic acid and 3,4-dihydroxyphenyllactic acids, and is mainly found in plant species including Boraginaceae and Lamiaceae. In this research, we determined the inhibition property of rosmarinic acid on carbonic anhydrase isoenzymes I and II (hCA I and II) purified from human erythrocytes by using Sepharose-4B affinity column chromatography. hCA I and II isoenzymes were obtained with a yield of 57.9% and 67.2% and 76.5- and 509.3-fold purification of each isoenzyme, respectively. In order to show the purity of the isoenzymes, SDS-PAGE was performed and one band was observed. In vitro inhibition of both hCA I and II isoenzymes by rosmarinic acid using CO 2 -esterase activity gave Ki values of 86.0 μ M and 57.0 μ M, respectively.
Anahtar Kelime:

Konular: Mühendislik, Kimya
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Topal M, Gulcin i (2014). Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor. , 894 - 902.
Chicago Topal Meryem,Gulcin ilhami Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor. (2014): 894 - 902.
MLA Topal Meryem,Gulcin ilhami Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor. , 2014, ss.894 - 902.
AMA Topal M,Gulcin i Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor. . 2014; 894 - 902.
Vancouver Topal M,Gulcin i Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor. . 2014; 894 - 902.
IEEE Topal M,Gulcin i "Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor." , ss.894 - 902, 2014.
ISNAD Topal, Meryem - Gulcin, ilhami. "Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor". (2014), 894-902.
APA Topal M, Gulcin i (2014). Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor. Turkish Journal of Chemistry, 38(5), 894 - 902.
Chicago Topal Meryem,Gulcin ilhami Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor. Turkish Journal of Chemistry 38, no.5 (2014): 894 - 902.
MLA Topal Meryem,Gulcin ilhami Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor. Turkish Journal of Chemistry, vol.38, no.5, 2014, ss.894 - 902.
AMA Topal M,Gulcin i Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor. Turkish Journal of Chemistry. 2014; 38(5): 894 - 902.
Vancouver Topal M,Gulcin i Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor. Turkish Journal of Chemistry. 2014; 38(5): 894 - 902.
IEEE Topal M,Gulcin i "Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor." Turkish Journal of Chemistry, 38, ss.894 - 902, 2014.
ISNAD Topal, Meryem - Gulcin, ilhami. "Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor". Turkish Journal of Chemistry 38/5 (2014), 894-902.
Sayfa Oluşturulma Tarihi
22-04-2024 20:25

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