Yıl: 2014 Cilt: 15 Sayı: 3 Sayfa Aralığı: 135 - 139 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The effects of a history of seizures during pregnancy on umbilical arterial blood gas values in pregnant women with epilepsy

Öz:
Objective: The objective of this study is to investigate if the number of seizures that occur during pregnancy has any effect on umbilical arterial blood gas values at delivery. Material and Methods: In total, 55 women who were 37 to 41 weeks pregnant and diagnosed with generalized tonic-clonic epilepsy and 50 pregnant women with similar characteristics but not diagnosed as epileptic were included in this study. The patients diagnosed with epilepsy were divided into two groups: 27 patients with a history of at least 5 epileptic seizures during pregnancy and 28 who had no seizures during pregnancy. All patients diagnosed with epilepsy had a history of caesarean delivery or a caesarean section under general anesthesia on the advice of neurology. Pregnant women in the control group were also chosen from among patients who had a caesarean on account of a previ- ous caesarean delivery. In the cases included in the study, umbilical arterial blood gas sampling was performed immediately after delivery. Results: When the control group without epilepsy was compared with pregnant women who had no history of epileptic seizures during preg- nancy, no difference was found in umbilical arterial blood gas values (p>0.05). When patients with a history of 5 or more epileptic seizures during pregnancy were compared with the control group without epilepsy and the patients with epilepsy who had no history of seizures during pregnancy, there was no statistically significant difference (p>0.05), although their umbilical arterial blood pH values were found to be lower, while partial carbon dioxide pressure (pCO2), values were higher and partial oxygen pressure (pO2) values were lower. Conclusion: Taking potential fetal risks into consideration, maternal generalized tonic-clonic epileptic seizures might be worrying. Tonic-clonic seizures that occur during pregnancy appear to be associated with temporary hypoxia. Therefore, monotherapy for seizures and treatment at the lowest effective dose should be administered to women with epilepsy in the preconception and prenatal term.
Anahtar Kelime:

Konular: Kadın Hastalıkları ve Doğum
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Richmond JR, Krishnamoorthy P, Andermann E, Benjamin A. Epilepsy and pregnancy: An obstetric perspective. Am J Obstet Gynecol 2004; 190: 371-9. [CrossRef]
  • 2.Dravet C, Julian C, Legras C, Magaudda A, Guerrini R, Genton P, et al. Epilepsy, antiepileptic drugs, and malformations in children of women with epilepsy: A French prospective cohort study. Neurology 1992; 42 (4 Suppl 5): 75-82.
  • 3.Yerby M, Koepsell T, Daling, J. Pregnancy complications and outcomes in a cohort of women with epilepsy. Epilepsia 1985; 26: 631-5. [CrossRef]
  • 4.Lindhout D, Meinardi H, Meijer JW, Nau H. Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescrip- tion policy paralleled by changes in pattern of malformations. Neurology 1992; 42 (4 Suppl 5): 94-110.
  • 5.Nelson KB, Ellenberg JH. Maternal seizure disorder, outcome of pregnancy, and neurologic abnormalities in the children. Neurology 1982; 32: 1247-54. [CrossRef]
  • 6. Teramo K, Hiilesmaa V, Bardy A, Saarikoski S. Fetal heart rate dur- ing a maternal grand mal epileptic seizure. J Perinat Med 1979; 7: 3-6. [CrossRef]
  • 7. ACOG Committee on Obstetric Practice. ACOG Committee Opinion No. 348, November 2006: Umbilical cord blood gas and acid-base analysis. Obstet Gynecol 2006; 108: 1319-22. [CrossRef]
  • 8. Yeomans ER, Hauth JC, Gilstrap LC, Strickland DM. Umbilical cord pH, PCO2 and bicarbonate following uncomplicated term vaginal deliveries. Am J Obstet Gynecol 1985; 151: 798-800. [CrossRef]
  • 9. Goldaber KG, Gilstrap LC. Correlations between clinical events and umbilical cord blood acid-base and blood gas values. Clin Obstet Gynecol 1993; 36: 47-59. [CrossRef]
  • 10. Gordon A, Johnson JW. Value of umbilical blood acid-base studies in fetal assessment. J Reprod Med 1985; 30: 329-36.
  • 11. Benian A, Uludağ S, Atış A, Gök M, Madazlı R. Analysis of umbilical cord blood acid-base status at birth. Cerrahpasa J Med 2002; 33: 236-44.
  • 12. Gilstrap LC. Fetal Acid-base Balance. In: Creasy RK, Resnik R, editors. Maternal-Fetal Medicine. Philadelphia: WB Saunders; 1998. p. 331.
  • 13. Minkoff H, Schaffer R, Delke I, Grunebaum N. Diagnosis of intracra- nial hemorrhage in utero after a maternal seizure. Obstet Gynecol 1985; 65 (3 Suppl): S22-24.
  • 14. Hiilesmaa VK, Teramo K, Bardy AH. Social Class, Complications, and Perinatal Deaths in Pregnancies of Epileptic Women: Preliminary Results of the Prospective Helsinki Study. In: Janz D, editors. Epilepsy, Pregnancy, and the Child. New York: Raven Press; 1982. p. 87-90.
  • 15. Atalla RK,Abram SK, Bell SC, Taylor DJ. Newborn acid-base status and umbilical cord morphology. Obstet Gynecol 1998; 92: 865-8. [CrossRef]
  • 16. Thorp JA, Dildy GA, Yeomans ER, Meyer BA, Parisi VM. Umbilical cord blood gas analysis at delivery. Am J Obstet Gynecol 1996; 175: 517-22. [CrossRef]
  • 17. Li CH, Zhu CX, He J. Effects of general anesthesia for cesarean sec- tion on infants. Zhonghua Fu Chan Ke Za Zhi 2006; 41: 162-4.
  • 18. Harrad J, Howell P. General anaesthesia for caesarean section. Curr Anaesth Crit Care 2000; 11: 66-72. [CrossRef]
  • 19. Dahlgren G, Granath F, Pregner K, Rösblad PG, Wessel H, Irestedt L. Colloid vs. crystalloid preloading to prevent maternal hypoten- sion during spinal anesthesia for elective cesarean section. Acta Anaesthesiol Scand 2005; 49: 1200-6. [CrossRef]
  • 20. Gregg AR, Weiner CP. “Normal” umbilical arterial and venous acid-base and blood gas values. Clin Obstet Gynecol 1993; 36: 24-32. [CrossRef]
  • 21. American Academy of Pediatrics, American College of Obstetricians and Gynecologists. Neonatal encephalopathy and cerebral palsy: defining the pathogenesis and pathophysiology. Elk Grove Village (IL): AAP; Washington, DC: ACOG; 2003.
  • 22. Bax M, Nelson KB. Birth asphyxia: A statement. World Federation of Neurology Group. Dev Med Child Neurol 1993; 35: 1022-4. [CrossRef]
  • 23. Low JA, Lindsay BG, Derrick EJ. Threshold of metabolic acidosis associated with newborn complications. Am J Obstet Gynecol 1997; 177: 1391-4. [CrossRef]
  • 24. Handley-Derry M, Low JA, Burke SO, Waurick M, Killen H, Derrick EJ. Intrapartum fetal asphyxia and the occurrence of minor deficits in 4- to 8-year-old children. Dev Med Child Neurol 1997; 39: 508-14. [CrossRef]
  • 25. Morrell MJ. Reproductive and metabolic disorders in women with epilepsy. Epilepsia 2003; 44 (Sup 4): 11-20.
  • 26. Sabers A, aRogvi-Hansen B, Dam M, Fischer-Rasmussen W, Gram L, Hansen M, et al. Pregnancy and epilepsy: A retrospective study of 151 pregnancies. Acta Neurol Scand 1998; 97: 164-70. [CrossRef]
APA özdemir ö, Sarı M, ARPACI E, Aslıhan KURT F, SELİMOVA V, ATALAY C (2014). The effects of a history of seizures during pregnancy on umbilical arterial blood gas values in pregnant women with epilepsy. , 135 - 139.
Chicago özdemir özhan,Sarı Mustafa Erkan,ARPACI Ertuğrul,Aslıhan KURT Funda,SELİMOVA Vefa,ATALAY Cemal The effects of a history of seizures during pregnancy on umbilical arterial blood gas values in pregnant women with epilepsy. (2014): 135 - 139.
MLA özdemir özhan,Sarı Mustafa Erkan,ARPACI Ertuğrul,Aslıhan KURT Funda,SELİMOVA Vefa,ATALAY Cemal The effects of a history of seizures during pregnancy on umbilical arterial blood gas values in pregnant women with epilepsy. , 2014, ss.135 - 139.
AMA özdemir ö,Sarı M,ARPACI E,Aslıhan KURT F,SELİMOVA V,ATALAY C The effects of a history of seizures during pregnancy on umbilical arterial blood gas values in pregnant women with epilepsy. . 2014; 135 - 139.
Vancouver özdemir ö,Sarı M,ARPACI E,Aslıhan KURT F,SELİMOVA V,ATALAY C The effects of a history of seizures during pregnancy on umbilical arterial blood gas values in pregnant women with epilepsy. . 2014; 135 - 139.
IEEE özdemir ö,Sarı M,ARPACI E,Aslıhan KURT F,SELİMOVA V,ATALAY C "The effects of a history of seizures during pregnancy on umbilical arterial blood gas values in pregnant women with epilepsy." , ss.135 - 139, 2014.
ISNAD özdemir, özhan vd. "The effects of a history of seizures during pregnancy on umbilical arterial blood gas values in pregnant women with epilepsy". (2014), 135-139.
APA özdemir ö, Sarı M, ARPACI E, Aslıhan KURT F, SELİMOVA V, ATALAY C (2014). The effects of a history of seizures during pregnancy on umbilical arterial blood gas values in pregnant women with epilepsy. Journal of the Turkish-German Gynecological Association, 15(3), 135 - 139.
Chicago özdemir özhan,Sarı Mustafa Erkan,ARPACI Ertuğrul,Aslıhan KURT Funda,SELİMOVA Vefa,ATALAY Cemal The effects of a history of seizures during pregnancy on umbilical arterial blood gas values in pregnant women with epilepsy. Journal of the Turkish-German Gynecological Association 15, no.3 (2014): 135 - 139.
MLA özdemir özhan,Sarı Mustafa Erkan,ARPACI Ertuğrul,Aslıhan KURT Funda,SELİMOVA Vefa,ATALAY Cemal The effects of a history of seizures during pregnancy on umbilical arterial blood gas values in pregnant women with epilepsy. Journal of the Turkish-German Gynecological Association, vol.15, no.3, 2014, ss.135 - 139.
AMA özdemir ö,Sarı M,ARPACI E,Aslıhan KURT F,SELİMOVA V,ATALAY C The effects of a history of seizures during pregnancy on umbilical arterial blood gas values in pregnant women with epilepsy. Journal of the Turkish-German Gynecological Association. 2014; 15(3): 135 - 139.
Vancouver özdemir ö,Sarı M,ARPACI E,Aslıhan KURT F,SELİMOVA V,ATALAY C The effects of a history of seizures during pregnancy on umbilical arterial blood gas values in pregnant women with epilepsy. Journal of the Turkish-German Gynecological Association. 2014; 15(3): 135 - 139.
IEEE özdemir ö,Sarı M,ARPACI E,Aslıhan KURT F,SELİMOVA V,ATALAY C "The effects of a history of seizures during pregnancy on umbilical arterial blood gas values in pregnant women with epilepsy." Journal of the Turkish-German Gynecological Association, 15, ss.135 - 139, 2014.
ISNAD özdemir, özhan vd. "The effects of a history of seizures during pregnancy on umbilical arterial blood gas values in pregnant women with epilepsy". Journal of the Turkish-German Gynecological Association 15/3 (2014), 135-139.