Increased epicardial fat tissue ıs a marker of subclinic atherosclerosis in ankylosing spondylitis

GÜLER, Hayal; Kurt, Mustafa; TURHANOĞLU, Ayşe Dicle; YAĞIZ, Erman; ATÇI, Nesrin; ÜSTÜN, Nilgün

Increased epicardial fat tissue ıs a marker of subclinic atherosclerosis in ankylosing spondylitis

Nilgün ÜSTÜN, (Mustafa Kemal Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Hatay, Türkiye)

Erman YAĞIZ, (Mustafa Kemal Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Hatay, Türkiye)

Hayal GÜLER, (Mustafa Kemal Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Hatay, Türkiye)

Ayşe Dicle TURHANOĞLU, (Mustafa Kemal Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Hatay, Türkiye)

Mustafa KURT, (Mustafa Kemal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Hatay, Türkiye)

Nesrin ATÇI (Mustafa Kemal Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Hatay, Türkiye)

Archives of Rheumatology

2 1

Yıl: 2014 Cilt: 29 Sayı: 4 Sayfa Aralığı: 267 - 272 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Increased epicardial fat tissue ıs a marker of subclinic atherosclerosis in ankylosing spondylitis

Öz:

Amaç: Çalışmada ankilozan spondilit (AS) hastalarında epikardiyal yağ kalınlığı, karotis intima media kalınlığı (CIMT) ve aortik sertlik indeksi (ASI) gibi subklinik ateroskleroz belirteçleri değerlendirildi ve ilaveten subklinik ateroskleroz belirteçleri ile hastalık aktivite/fonksiyon/mobilite indeksleri arasındaki ilişki araştırıldı. Hastalar ve yöntemler: Çalışmaya 26 AS hastası (22 erkek, 4 kadın; ort. yaş 43 yıl) ve yaş ve cinsiyet uyumlu 26 sağlıklı kontrol (21 erkek, 5 kadın; ort. yaş 42 yıl) alındı. Kardiyovasküler veya eşlik eden hastalıkları olan hastalar ve kontroller çalışmadan çıkarıldı. Hastalık aktivitesi Bath Ankilozan Spondilit Hastalık Aktivite İndeksi, fonksiyonel kapasite Bath Ankilozan Spondilit Fonksiyonel İndeksi ve mobilite durumu Bath Ankilozan Spondilit Metroloji İndeksi ile değerlendirildi. Tüm hastalar epikardiyal yağ kalınlığı ve ASI .l.ülmek üzere transtorasik ekokardiyografiye ve CIMT .l.ülmek üzere ultrason ile muayeneye tabi tutuldu. Bulgular: Ankilozan spondilitli hastalar ve kontroller arasında demografik ve kardiyovasküler özellikler açısından anlamlı fark yoktu (p>0.05). Epikardiyal yağ kalınlığı (5.15±1.13 ve 4.11±1.22; p=0.003), CIMT (0.70±0.16 ve 0.60±0.10; p=0.012) ve ASI (14.2±10.8 ve 8.6±3.1; p=0.018) değerleri kontrollere kıyasla hastalarda daha yüksek idi. Subklinik ateroskleroz belirteçleri ile hastalık aktivite/fonksiyon/mobilite indeksleri arasında anlamlı ilişki yoktu (p>0.05). Sonuç: Ankilozan spondilit hastalarında sağlıklı kontrollere kıyasla epikardiyal yağ kalınlığı, CIMT ve ASI anlamlı olarak daha yüksekti.

Anahtar Kelime:

Konular: Romatoloji

Ankilozan spondilitte artmış epikardiyal yağ dokusu subklinik aterosklerozun bir belirtecidir

Öz:

Objectives: This study aims to assess subclinical atherosclerosis markers such as epicardial fat thickness, carotid intima media thickness (CIMT), and aortic stiffness index (ASI) in ankylosing spondylitis (AS) patients as well as to investigate the relationship between the subclinical atherosclerosis markers and disease activity/function/mobility indices. Patients and methods: Twenty-six AS patients (22 males, 4 females; mean age 43 years) and 26 age- and sex-matched healthy controls (21 males, 5 females; mean age 43 years) were included. Patients and controls with any reported cardiovascular disease or other comorbidities were excluded. Disease activity, functional capacity and spinal mobility were measured using the Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, and Bath Ankylosing Spondylitis Metrology Index, respectively. All patients underwent complete transthoracic echocardiographic examination including epicardial fat thickness and ASI, and sonographic examination including CIMT. Results: There were no significant differences in demographical and cardiovascular characteristics between AS patients and healthy controls (p>0.05). Epicardial fat thickness (5.15±1.13 vs. 4.11±1.22; p=0.003), CIMT (0.70±0.16 vs. 0.60±0.10; p=0.012) and ASI (14.2±10.8 vs. 8.6±3.1; p=0.018) were significantly increased in patients with AS compared to the healthy controls. There was no significant correlation between the subclinical atherosclerosis markers and disease activity/function/mobility indices (p>0.05). Conclusion: A significantly increased epicardial fat thickness, CIMT, and ASI were observed in AS patients compared with healthy controls.

Anahtar Kelime:

Konular: Romatoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÜSTÜN N, YAĞIZ E, GÜLER H, TURHANOĞLU A, Kurt M, ATÇI N (2014). Increased epicardial fat tissue ıs a marker of subclinic atherosclerosis in ankylosing spondylitis. , 267 - 272.
Chicago	ÜSTÜN Nilgün,YAĞIZ Erman,GÜLER Hayal,TURHANOĞLU Ayşe Dicle,Kurt Mustafa,ATÇI Nesrin Increased epicardial fat tissue ıs a marker of subclinic atherosclerosis in ankylosing spondylitis. (2014): 267 - 272.
MLA	ÜSTÜN Nilgün,YAĞIZ Erman,GÜLER Hayal,TURHANOĞLU Ayşe Dicle,Kurt Mustafa,ATÇI Nesrin Increased epicardial fat tissue ıs a marker of subclinic atherosclerosis in ankylosing spondylitis. , 2014, ss.267 - 272.
AMA	ÜSTÜN N,YAĞIZ E,GÜLER H,TURHANOĞLU A,Kurt M,ATÇI N Increased epicardial fat tissue ıs a marker of subclinic atherosclerosis in ankylosing spondylitis. . 2014; 267 - 272.
Vancouver	ÜSTÜN N,YAĞIZ E,GÜLER H,TURHANOĞLU A,Kurt M,ATÇI N Increased epicardial fat tissue ıs a marker of subclinic atherosclerosis in ankylosing spondylitis. . 2014; 267 - 272.
IEEE	ÜSTÜN N,YAĞIZ E,GÜLER H,TURHANOĞLU A,Kurt M,ATÇI N "Increased epicardial fat tissue ıs a marker of subclinic atherosclerosis in ankylosing spondylitis." , ss.267 - 272, 2014.
ISNAD	ÜSTÜN, Nilgün vd. "Increased epicardial fat tissue ıs a marker of subclinic atherosclerosis in ankylosing spondylitis". (2014), 267-272.

APA	ÜSTÜN N, YAĞIZ E, GÜLER H, TURHANOĞLU A, Kurt M, ATÇI N (2014). Increased epicardial fat tissue ıs a marker of subclinic atherosclerosis in ankylosing spondylitis. Archives of Rheumatology, 29(4), 267 - 272.
Chicago	ÜSTÜN Nilgün,YAĞIZ Erman,GÜLER Hayal,TURHANOĞLU Ayşe Dicle,Kurt Mustafa,ATÇI Nesrin Increased epicardial fat tissue ıs a marker of subclinic atherosclerosis in ankylosing spondylitis. Archives of Rheumatology 29, no.4 (2014): 267 - 272.
MLA	ÜSTÜN Nilgün,YAĞIZ Erman,GÜLER Hayal,TURHANOĞLU Ayşe Dicle,Kurt Mustafa,ATÇI Nesrin Increased epicardial fat tissue ıs a marker of subclinic atherosclerosis in ankylosing spondylitis. Archives of Rheumatology, vol.29, no.4, 2014, ss.267 - 272.
AMA	ÜSTÜN N,YAĞIZ E,GÜLER H,TURHANOĞLU A,Kurt M,ATÇI N Increased epicardial fat tissue ıs a marker of subclinic atherosclerosis in ankylosing spondylitis. Archives of Rheumatology. 2014; 29(4): 267 - 272.
Vancouver	ÜSTÜN N,YAĞIZ E,GÜLER H,TURHANOĞLU A,Kurt M,ATÇI N Increased epicardial fat tissue ıs a marker of subclinic atherosclerosis in ankylosing spondylitis. Archives of Rheumatology. 2014; 29(4): 267 - 272.
IEEE	ÜSTÜN N,YAĞIZ E,GÜLER H,TURHANOĞLU A,Kurt M,ATÇI N "Increased epicardial fat tissue ıs a marker of subclinic atherosclerosis in ankylosing spondylitis." Archives of Rheumatology, 29, ss.267 - 272, 2014.
ISNAD	ÜSTÜN, Nilgün vd. "Increased epicardial fat tissue ıs a marker of subclinic atherosclerosis in ankylosing spondylitis". Archives of Rheumatology 29/4 (2014), 267-272.