Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles

Ayşe Selen ALP, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasotik Kimya Bölümü, Ankara, Türkiye)
Gülgün KILCIGİL, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasotik Kimya Bölümü, Ankara, Türkiye)
Elçin Deniz ÖZDAMAR, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji, Anabilim Dalı, Ankara, Türkiye)
Tülay ÇOBAN, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji, Anabilim Dalı, Ankara, Türkiye)
Binay EKE (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji, Anabilim Dalı, Ankara, Türkiye)
Turkish Journal of Chemistry
0 0
Yıl: 2015 Cilt: 39 Sayı: 1 Sayfa Aralığı: 42 - 53 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles

Öz:
Abstract: Some novel 2-(substitutedbenzylthio)-5-((2-(4-substitutedphenyl)-1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazoles (5--12) and 2-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)-N'-(arylmethylene)acetohydrazide derivatives (13--22) were prepared and their in vitro antioxidant properties were investigated by determination of rat liver microsomal NADPH-dependent inhibition of lipid peroxidation (LP) levels and microsomal ethoxyresorufin O-deethylase (EROD) activity. Compound 18 was found to be the most active compound with 100% inhibition on LP level and 92% inhibition on EROD. Compounds 4b, 17, and 19 showed the strongest inhibitory effect (97%) on EROD. The free radical scavenging capacities of the compounds were also tested in vitro determining the interaction of the stable free radical 2,2,diphenyl-1-picrylhydrazyl (DPPH), and compounds 4a and 4b exhibited good antioxidant activities.
Anahtar Kelime:

Konular: Mühendislik, Kimya
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ALP A, Kılcıgil G, ÖZDAMAR E, ÇOBAN T, EKE B (2015). Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles. , 42 - 53.
Chicago ALP AYŞE SELEN,Kılcıgil Gülgün,ÖZDAMAR Elçin Deniz,ÇOBAN TÜLAY,EKE BİNAY Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles. (2015): 42 - 53.
MLA ALP AYŞE SELEN,Kılcıgil Gülgün,ÖZDAMAR Elçin Deniz,ÇOBAN TÜLAY,EKE BİNAY Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles. , 2015, ss.42 - 53.
AMA ALP A,Kılcıgil G,ÖZDAMAR E,ÇOBAN T,EKE B Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles. . 2015; 42 - 53.
Vancouver ALP A,Kılcıgil G,ÖZDAMAR E,ÇOBAN T,EKE B Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles. . 2015; 42 - 53.
IEEE ALP A,Kılcıgil G,ÖZDAMAR E,ÇOBAN T,EKE B "Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles." , ss.42 - 53, 2015.
ISNAD ALP, AYŞE SELEN vd. "Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles". (2015), 42-53.
APA ALP A, Kılcıgil G, ÖZDAMAR E, ÇOBAN T, EKE B (2015). Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles. Turkish Journal of Chemistry, 39(1), 42 - 53.
Chicago ALP AYŞE SELEN,Kılcıgil Gülgün,ÖZDAMAR Elçin Deniz,ÇOBAN TÜLAY,EKE BİNAY Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles. Turkish Journal of Chemistry 39, no.1 (2015): 42 - 53.
MLA ALP AYŞE SELEN,Kılcıgil Gülgün,ÖZDAMAR Elçin Deniz,ÇOBAN TÜLAY,EKE BİNAY Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles. Turkish Journal of Chemistry, vol.39, no.1, 2015, ss.42 - 53.
AMA ALP A,Kılcıgil G,ÖZDAMAR E,ÇOBAN T,EKE B Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles. Turkish Journal of Chemistry. 2015; 39(1): 42 - 53.
Vancouver ALP A,Kılcıgil G,ÖZDAMAR E,ÇOBAN T,EKE B Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles. Turkish Journal of Chemistry. 2015; 39(1): 42 - 53.
IEEE ALP A,Kılcıgil G,ÖZDAMAR E,ÇOBAN T,EKE B "Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles." Turkish Journal of Chemistry, 39, ss.42 - 53, 2015.
ISNAD ALP, AYŞE SELEN vd. "Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles". Turkish Journal of Chemistry 39/1 (2015), 42-53.
Sayfa Oluşturulma Tarihi
22-04-2024 21:3

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