D Vitamini, kalsiyum & mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel D vitamini kullanımı

YAVUZ, Rahman; METE, Türkan; YAVUZ, DEMET; ALTUNOGLU, Alpaslan

D Vitamini, kalsiyum & mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel D vitamini kullanımı

Demet YAVUZ, (Samsun Eğitim ve Araştırma Hastanesi, Nefroloji Kliniği, Samsun, Türkiye)

Türkan METE, (Samsun Eğitim Araştırma Hastanesi Endokrinoloji Kliniği, Samsun, Türkiye)

Rahman YAVUZ, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Tıp Eğitimi Anabilim Dalı, Samsun, Türkiye)

Alpaslan ALTUNOGLU (Atatürk Eğitim ve Araştırma Hastanesi, Nefroloji Kliniği, Ankara, Türkiye)

Ankara Medical Journal

20 6

Yıl: 2014 Cilt: 14 Sayı: 4 Sayfa Aralığı: 162 - 169 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

D Vitamini, kalsiyum & mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel D vitamini kullanımı

Öz:

Vitamin D, güneş ışığı ile temas sonucu deride üretilen, yağda çözünen, secosteroid yapıda bir prohormondur. Vücuttaçeşitli metabolik değişikliklerle kalsitriol olarak bilinen, kalsiyum ve fosfor metabolizmasında önemli rol oynayan birhormona dönüşür. Böbrek dokusu haricinde D vitaminine ait reseptörler; T lenfositler, beyin, prostat, pankreas, gonadlar, meme dokusu,kas ve kolon gibi birçok organ ve dokuda bulunmaktadır. D vitamininin etkinliği sadece kalsiyum homeostazisinidüzenleyerek kemik sağlığını idame ettirmekle sınırlı olmayıp, aynı zamanda pro-apopitotik, antienfamatuar veimmün-modülatuar özelliklere sahip olduğu bildirilmektedir. Son yıllarda yapılan epidemiyolojik çalışmalarda,düşük D vitamini düzeyinin kanser insidansını ve kardiyovasiküler mortaliteyi arttırdığı, diyabet ve multipl sklerozgibi otoimmün hastalıklar ile birlikte olduğu bildirilmiştir. Kronik böbrek yetmezliğinin (KBY) gelişmesi, 1,25 dihidroksi D vitamini üretiminde progresif azalma ile ilişkilidir.Düşük 25-hidroksi vitamin D seviyeleri kronik böbrek yetmezliğinin tüm evrelerinde gözlenmekte ve sekonderhiperparatiroidizme neden olmaktadır. KBY hastalarında bilinen D vitamini önemli biyolojik etkileri, 25 hidroksivitamin Dnin 1-25 dihidroksi D vitaminine extrarenal dönüşümü sayesinde gerçekleşmektedir. Bu derleme D vitamini,kalsiyum-mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel Dvitamini kullanımı gözden geçirilmiştir.

Anahtar Kelime:

Konular: Beslenme ve Diyetetik Genel ve Dahili Tıp

Vitamin D, calcium & mineral metabolism, extraskeletal effects of vitamin D and the use of nutritional vitamin D in chronic kidney disease

Öz:

Vitamin D is a liposoluble prohormon and and a secosteroid that is produced in the skin after exposure to sunlight.It is turned to calcitriol that has an important role in the calcium and phosphate metabolism by different metabolicpathways. Vitamin D receptors excluding kidney tissues are available in the following organs and tissues; T lenfosit, brain,prostate, pancreas, gonad, breast tissues, muscles and colon. It is known that function of Vitamin D is not only tomaintain healthy bones through arranging calcium homeostasis but also has pro-apopitotic, anti-infammatory andimmune modulator characteristics. In recent epidemiologic studies, low level vitamin D increases cancer incidenceand cardiovascular mortality and comes along with auto-immune low levels of vitamin D and diabetes mellitus. The development of chronic kidney disease (CKD) is accompained by a progressive reduce in ability to produce1,25-dihydroxyvitamin D. Low 25-hydroxyvitamin D levels are common in patients with all the stages of CKDand this stuation has triggered the secondary hyperparathyroidism in CKD patients. Extrarenal conversion of25-hydroxyvitamin D to 1,5-dihydroxyvitamin D may have signifcant biological role beyond those traditionallyascribed to vitamin D. In this review, we checked out vitamin D, calcium-mineral metabolism, the extraskeletal effectof vitamin D, and nutritional vitamin D replacement in CKD.

Anahtar Kelime:

Konular: Beslenme ve Diyetetik Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	YAVUZ D, METE T, YAVUZ R, ALTUNOGLU A (2014). D Vitamini, kalsiyum & mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel D vitamini kullanımı. , 162 - 169.
Chicago	YAVUZ DEMET,METE Türkan,YAVUZ Rahman,ALTUNOGLU Alpaslan D Vitamini, kalsiyum & mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel D vitamini kullanımı. (2014): 162 - 169.
MLA	YAVUZ DEMET,METE Türkan,YAVUZ Rahman,ALTUNOGLU Alpaslan D Vitamini, kalsiyum & mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel D vitamini kullanımı. , 2014, ss.162 - 169.
AMA	YAVUZ D,METE T,YAVUZ R,ALTUNOGLU A D Vitamini, kalsiyum & mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel D vitamini kullanımı. . 2014; 162 - 169.
Vancouver	YAVUZ D,METE T,YAVUZ R,ALTUNOGLU A D Vitamini, kalsiyum & mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel D vitamini kullanımı. . 2014; 162 - 169.
IEEE	YAVUZ D,METE T,YAVUZ R,ALTUNOGLU A "D Vitamini, kalsiyum & mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel D vitamini kullanımı." , ss.162 - 169, 2014.
ISNAD	YAVUZ, DEMET vd. "D Vitamini, kalsiyum & mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel D vitamini kullanımı". (2014), 162-169.

APA	YAVUZ D, METE T, YAVUZ R, ALTUNOGLU A (2014). D Vitamini, kalsiyum & mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel D vitamini kullanımı. Ankara Medical Journal, 14(4), 162 - 169.
Chicago	YAVUZ DEMET,METE Türkan,YAVUZ Rahman,ALTUNOGLU Alpaslan D Vitamini, kalsiyum & mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel D vitamini kullanımı. Ankara Medical Journal 14, no.4 (2014): 162 - 169.
MLA	YAVUZ DEMET,METE Türkan,YAVUZ Rahman,ALTUNOGLU Alpaslan D Vitamini, kalsiyum & mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel D vitamini kullanımı. Ankara Medical Journal, vol.14, no.4, 2014, ss.162 - 169.
AMA	YAVUZ D,METE T,YAVUZ R,ALTUNOGLU A D Vitamini, kalsiyum & mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel D vitamini kullanımı. Ankara Medical Journal. 2014; 14(4): 162 - 169.
Vancouver	YAVUZ D,METE T,YAVUZ R,ALTUNOGLU A D Vitamini, kalsiyum & mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel D vitamini kullanımı. Ankara Medical Journal. 2014; 14(4): 162 - 169.
IEEE	YAVUZ D,METE T,YAVUZ R,ALTUNOGLU A "D Vitamini, kalsiyum & mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel D vitamini kullanımı." Ankara Medical Journal, 14, ss.162 - 169, 2014.
ISNAD	YAVUZ, DEMET vd. "D Vitamini, kalsiyum & mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronik böbrek yetmezliğinde nutrisyonel D vitamini kullanımı". Ankara Medical Journal 14/4 (2014), 162-169.