Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center

PEKTAŞ, AYHAN; GÜRGEY, Aytemiz; Kara, Ates

Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center

Ayhan PEKTAŞ, (Afyon Kocatepe Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Afyonkarahisar, Türkiye)

Ateş KARA, (Hacettepe Üniversitesi, Tıp Fakültesi, İhsan Doğramacı Çocuk Hastanesi, Çocuk Enfeksiyon Hastalıkları Kliniği, Ankara, Türkiye)

Aytemiz GÜRGEY (Hacettepe Üniversitesi, Tıp Fakültesi, Çocuk Hematoloji Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Hematology

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Yıl: 2015 Cilt: 32 Sayı: 2 Sayfa Aralığı: 144 - 151 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center

Öz:

Amaç: Bu çalışma, tek bir merkezde hematolojik hastalık nedeniyle tedavi edilen çocuklarda santral venöz kateter (SVK)kullanımıyla ilişkili olarak ortaya çıkan komplikasyonları belirlemeyi ve incelemeyi amaçlamaktadır. Gereç ve Yöntemler: Beş yıl boyunca, 203 SVK uygulaması yapılan 106 çocuk hastada ortaya çıkan 175 katetere bağlıkomplikasyon geriye dönük olarak değerlendirilmiştir.Bulgular: Klinik kateter enfeksiyonu, lokal kateter enfeksiyonu, venöz tromboembolizm, kanama ve mekanik komplikasyonoranları, sırasıyla, 1000 kateter gününde 2,6, 1,1, 0,2, 0,2 ve 0,2 olarak hesaplanmıştır. Metisiline dirençli Staphylococcusepidermidis, kan ve kateter kültürlerinden en çok izole edilen mikroorganizmadır. Lösemili çocuklarda klinik kateterenfeksiyonlarının sıklığı anlamlı olarak yüksektir (p=0,046). Kemik iliği transplantasyonu yapılan çocuklarda klinik kateterenfeksiyonu sıklığı anlamlı olarak düşük (p=0,043) bulunurken lokal kateter enfeksiyonu sıklığı anlamlı olarak yüksektir(p=0,003). İmplante kateteri olan çocuklarda klinik kateter enfeksiyonlarının sıklığı anlamlı olarak düşüktür (p=0,048).Trombositopenisi olan çocuklarda lokal kateter enfeksiyonları anlamlı olarak daha az görülürken klinik kateter enfeksiyonlarıve katetere bağlı kanama anlamlı olarak daha sık ortaya çıkmıştır (sırasıyla p=0,001, p=0,042 ve p=0,024).Sonuç: Lösemi, kemik iliği transplantasyonu ve trombositopeni, SVK ile ilişkili olarak çocuklarda ortaya çıkan komplikasyonlariçin en önemli risk etkenleridir. Kalıcı kateterler aracılığıyla gerçekleştirilen müdahale sayısındaki artış, sistemik enfeksiyonve mekanik hasar riskindeki anlamlı yükselişten sorumlu olabilir.

Anahtar Kelime:

Konular: Hematoloji

Kohort Çalışması: Tek Bir Merkezde Hematolojik Hastalık Nedeniyle Tedavi Edilen Çocuklarda Santral Venöz Kateter Kullanımıyla İlişkili Olarak Ortaya Çıkan Komplikasyonlar

Öz:

Objective: This study aims to document and analyze the central venous catheter (CVC)-related complications in childrenwith hematological diseases who were treated within a single institution. Materials and Methods: A retrospective investigation was conducted in 106 pediatric patients in whom 203 CVCs wereinserted. A total of 175 catheter-related complications occurred in 5 years. Results: The rates of clinical catheter infections, local catheter infections, venous thromboembolism, bleeding, and mechanicalcomplications were 2.6, 1.1, 0.2, 0.2, and 0.2 per 1000 catheter days. Methicillin-resistant Staphylococcus epidermidis wasthe predominant infectious organism in blood and catheter cultures. The children with leukemia had a significantly higherfrequency of clinical catheter infections (p=0.046). The children who underwent bone marrow transplantation had a significantlylower frequency of clinical catheter infections (p=0.043) and higher frequency of local catheter infections (p=0.003). Thechildren with implanted catheters had a significantly lower frequency of clinical catheter infections (p=0.048). The childrenwith thrombocytopenia had significantly fewer local catheter infections and significantly more clinical catheter infections andcatheter-related bleeding (respectively p=0.001, p=0.042, and p=0.024).Conclusion: Leukemia, bone marrow transplantation, and thrombocytopenia are risk factors for CVC-associatedcomplications. The relatively higher number of interventions performed via permanent catheters may be responsible for thesignificantly increased incidence of systemic infections and mechanical injury.

Anahtar Kelime:

Konular: Hematoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	PEKTAŞ A, Kara A, GÜRGEY A (2015). Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center. , 144 - 151.
Chicago	PEKTAŞ AYHAN,Kara Ates,GÜRGEY Aytemiz Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center. (2015): 144 - 151.
MLA	PEKTAŞ AYHAN,Kara Ates,GÜRGEY Aytemiz Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center. , 2015, ss.144 - 151.
AMA	PEKTAŞ A,Kara A,GÜRGEY A Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center. . 2015; 144 - 151.
Vancouver	PEKTAŞ A,Kara A,GÜRGEY A Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center. . 2015; 144 - 151.
IEEE	PEKTAŞ A,Kara A,GÜRGEY A "Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center." , ss.144 - 151, 2015.
ISNAD	PEKTAŞ, AYHAN vd. "Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center". (2015), 144-151.

APA	PEKTAŞ A, Kara A, GÜRGEY A (2015). Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center. Turkish Journal of Hematology, 32(2), 144 - 151.
Chicago	PEKTAŞ AYHAN,Kara Ates,GÜRGEY Aytemiz Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center. Turkish Journal of Hematology 32, no.2 (2015): 144 - 151.
MLA	PEKTAŞ AYHAN,Kara Ates,GÜRGEY Aytemiz Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center. Turkish Journal of Hematology, vol.32, no.2, 2015, ss.144 - 151.
AMA	PEKTAŞ A,Kara A,GÜRGEY A Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center. Turkish Journal of Hematology. 2015; 32(2): 144 - 151.
Vancouver	PEKTAŞ A,Kara A,GÜRGEY A Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center. Turkish Journal of Hematology. 2015; 32(2): 144 - 151.
IEEE	PEKTAŞ A,Kara A,GÜRGEY A "Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center." Turkish Journal of Hematology, 32, ss.144 - 151, 2015.
ISNAD	PEKTAŞ, AYHAN vd. "Cohort Study: Central Venous Catheter-Related Complications in Children with Hematologic Diseases at a Single Center". Turkish Journal of Hematology 32/2 (2015), 144-151.