Mikro RNA ve Kanser

ŞAŞMAZ, Hatice ilgen; KARAGÜN, BARBAROS ŞAHİN; Antmen, Bulent; KILINÇ, Yurdanur

Mikro RNA ve Kanser

Barbaros Şahin KARAGÜN, (Çukurova Üniversitesi, Tıp Fakültesi, Çocuk Hematoloji Anabilim Dalı, Adana, Türkiye)

Bülent ANTMEN, (Çukurova Üniversitesi, Tıp Fakültesi, Çocuk Hematoloji Anabilim Dalı, Adana, Türkiye)

Hatice İLGEN ŞAŞMAZ, (Çukurova Üniversitesi, Tıp Fakültesi, Çocuk Hematoloji Anabilim Dalı, Adana, Türkiye)

Yurdanur KILINÇ (Çukurova Üniversitesi, Tıp Fakültesi, Çocuk Hematoloji Anabilim Dalı, Adana, Türkiye)

Türk Klinik Biyokimya Dergisi

7 3

Yıl: 2014 Cilt: 12 Sayı: 1 Sayfa Aralığı: 45 - 56 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Mikro RNA ve Kanser

Öz:

MikroRNA'lar, genom üzerinde protein kodlayan intron veya ekzon bölgeleri ve protein kodlamayan bölgelerdeki RNA genlerinden transkripsiyonu sağlanan, fakat proteine translasyonu gerçekleşmeyen, fonksiyonel RNA molekülleridir. MikroRNAlar protein translasyonunun inhibisyonuna ve/veya mRNA'nın yıkımına neden olur. Yapılan çoğu çalışmada bu küçük moleküllerin hematopoezde farklılaşma, çoğalma ve apopitoz gibi çok önemli hücresel olaylarda kritik öneme sahip olduğunu göstermiştir. Malign hastalıklardaki rolü giderek daha fazla araştırmanın konusu olmaktadır. MikroRNAlar bir ya da birden fazla hedef geni baskılayarak hücrenin gelişim, farklılaşma, çoğalma, ölümü gibi farklı olaylarda rol oynarlar. miRNA genlerinin %50'sinden fazlası kanser ile ilişkilendirilmiş genom üerinde bulunur. Yapılan çok sayıda deneysel çalışma; miRNA'ların yeni bir onkogen veya tümör baskılayıcı gen sınıfı oluşturabileceğini göstermiştir. Normal ve patolojik dokular arasında farklı seviyede ifade edilen miRNA'lar tespit edilerek, insan kanserlerinde tanı ve tedavide etkili olabilecek yeni miRNA'lar belirlenebilecektir.

Anahtar Kelime:

Konular: Biyoloji Mikrobiyoloji Biyoteknoloji ve Uygulamalı Mikrobiyoloji

Mikro RNA and Cancer

Öz:

Mikro-RNAs are functional, non-protein coding RNA molecules and their transcriptions provided by intron or exon regions of the genome and non-protein coding regions of RNA genes. Mikro-RNAs inhibit translation of protein and / or cause destruction of mRNA. Most of studies have demonstrated that many of these small molecules have critical importance in many important cellular events such as hematopoiesis, differentiation, proliferation and apoptosis. The role of mikro-RNAs in malign diseases have become the subject of research increasingly. Mikro-RNAs play a role in different events such as cell growth, differentiation, proliferation and death by suppressing one or more target gene. More than 50% of miRNA genes are located on the genome which has associated with cancer. A large number of experimental studies show that miRNAs may have generate a new class of oncogenes or tumor suppressor gene. MiRNAs are thought to be identified at a different level of expression in normal and pathological tissues can be determined between the miRNAs that are effective diagnosis and treatment of human cancers.

Anahtar Kelime:

Konular: Biyoloji Mikrobiyoloji Biyoteknoloji ve Uygulamalı Mikrobiyoloji

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	KARAGÜN B, Antmen B, ŞAŞMAZ H, KILINÇ Y (2014). Mikro RNA ve Kanser. , 45 - 56.
Chicago	KARAGÜN BARBAROS ŞAHİN,Antmen Bulent,ŞAŞMAZ Hatice ilgen,KILINÇ Yurdanur Mikro RNA ve Kanser. (2014): 45 - 56.
MLA	KARAGÜN BARBAROS ŞAHİN,Antmen Bulent,ŞAŞMAZ Hatice ilgen,KILINÇ Yurdanur Mikro RNA ve Kanser. , 2014, ss.45 - 56.
AMA	KARAGÜN B,Antmen B,ŞAŞMAZ H,KILINÇ Y Mikro RNA ve Kanser. . 2014; 45 - 56.
Vancouver	KARAGÜN B,Antmen B,ŞAŞMAZ H,KILINÇ Y Mikro RNA ve Kanser. . 2014; 45 - 56.
IEEE	KARAGÜN B,Antmen B,ŞAŞMAZ H,KILINÇ Y "Mikro RNA ve Kanser." , ss.45 - 56, 2014.
ISNAD	KARAGÜN, BARBAROS ŞAHİN vd. "Mikro RNA ve Kanser". (2014), 45-56.

APA	KARAGÜN B, Antmen B, ŞAŞMAZ H, KILINÇ Y (2014). Mikro RNA ve Kanser. Türk Klinik Biyokimya Dergisi, 12(1), 45 - 56.
Chicago	KARAGÜN BARBAROS ŞAHİN,Antmen Bulent,ŞAŞMAZ Hatice ilgen,KILINÇ Yurdanur Mikro RNA ve Kanser. Türk Klinik Biyokimya Dergisi 12, no.1 (2014): 45 - 56.
MLA	KARAGÜN BARBAROS ŞAHİN,Antmen Bulent,ŞAŞMAZ Hatice ilgen,KILINÇ Yurdanur Mikro RNA ve Kanser. Türk Klinik Biyokimya Dergisi, vol.12, no.1, 2014, ss.45 - 56.
AMA	KARAGÜN B,Antmen B,ŞAŞMAZ H,KILINÇ Y Mikro RNA ve Kanser. Türk Klinik Biyokimya Dergisi. 2014; 12(1): 45 - 56.
Vancouver	KARAGÜN B,Antmen B,ŞAŞMAZ H,KILINÇ Y Mikro RNA ve Kanser. Türk Klinik Biyokimya Dergisi. 2014; 12(1): 45 - 56.
IEEE	KARAGÜN B,Antmen B,ŞAŞMAZ H,KILINÇ Y "Mikro RNA ve Kanser." Türk Klinik Biyokimya Dergisi, 12, ss.45 - 56, 2014.
ISNAD	KARAGÜN, BARBAROS ŞAHİN vd. "Mikro RNA ve Kanser". Türk Klinik Biyokimya Dergisi 12/1 (2014), 45-56.