Efficacy of Intra-Articular Autologous Platelet Rich Plasma Application in Knee Osteoarthritis

YAZICIOĞLU, Jülide Aksel; SÜTBEYAZ TOMRUK, Serap; SAYAN, Hatice; KOÇ, ALİ; TALAY ÇALIŞ, Havva; HALICI, Canan; KONK, Metin; GÜLER, Emel

Efficacy of Intra-Articular Autologous Platelet Rich Plasma Application in Knee Osteoarthritis

Havva TALAY ÇALIŞ, (Sağlık Bakanlığı, Kayseri Eğitim ve Araştırma Hastanesi, Fiziksel Tıp ve Rehabilitasyon Kliniği, Kayseri, Türkiye)

Serap SÜTBEYAZ TOMRUK, (Sağlık Bakanlığı, Kayseri Eğitim ve Araştırma Hastanesi, Fiziksel Tıp ve Rehabilitasyon Kliniği, Kayseri, Türkiye)

Emel GÜLER, (Sağlık Bakanlığı, Kayseri Eğitim ve Araştırma Hastanesi, Fiziksel Tıp ve Rehabilitasyon Kliniği, Kayseri, Türkiye)

Canan HALICI, (Kartal Yavuz Selim Devlet Hastanesi, Biyokimya Bölümü, İstanbul, Türkiye)

Hatice SAYAN, (Sağlık Bakanlığı, Kayseri Eğitim ve Araştırma Hastanesi, Fiziksel Tıp ve Rehabilitasyon Kliniği, Kayseri, Türkiye)

Ali KOÇ, (Kayseri Eğitim ve Araştırma Hastanesi, Radyoloji Kliniği, Kayseri, Türkiye)

Metin KONK, (Sağlık Bakanlığı, Kayseri Eğitim ve Araştırma Hastanesi, Biyokimya Kliniği, Kayseri, Türkiye)

Jülide Aksel YAZICIOĞLU (Sağlık Bakanlığı, Kayseri Eğitim ve Araştırma Hastanesi, Fiziksel Tıp ve Rehabilitasyon Kliniği, Kayseri, Türkiye)

Archives of Rheumatology

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Yıl: 2015 Cilt: 30 Sayı: 3 Sayfa Aralığı: 198 - 205 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Efficacy of Intra-Articular Autologous Platelet Rich Plasma Application in Knee Osteoarthritis

Öz:

Objectives: This study aims to evaluate the efficacy of autologous platelet rich plasma applications on pain, functional status, and cartilage regeneration in advanced knee osteoarthritis. Patients and methods: A total of 82 patients (13 males, 69 females; mean age 63.5±9.3 years; range 40 to 88 years) with chronic knee pain for the last one year, who had grade 3-4 knee osteoarthritis according to Kellgren-Lawrence Scale and visual analog scale value of higher than 5, who did not receive physical therapy for the last six months, and did not respond to treatment despite use of nonsteroidal antiinflammatory drugs and analgesics at least for the last three months were enrolled in the study. Totally 103 knee joints of 82 patients were applied intra-articular platelet rich plasma in the beginning, and first and second weeks of treatment. Platelet rich plasma was applied to both knees in 20 patients. Patients were evaluated clinically with visual analog scale, functionally with Western Ontario and McMaster Universities Osteoarthritis Index, and six-minute walk test before application and after application at first and second weeks, and third and sixth months. Cartilage thicknesses were measured by ultrasound before treatment and at third and sixth months after treatment. Obtained results were compared. Results: Compared to values before treatment, patients visual analog scale values were significantly decreased at third and sixth months after treatment (p<0.001). When compared according to Western Ontario and McMaster Universities Osteoarthritis Index, all values improved significantly after treatment (p<0.001). Results of six-minute walk test improved at third and sixth moths after treatment compared to results before treatment (p<0.05). Cartilage thicknesses increased significantly after treatment at third and sixth months compared to before treatment (p<0.05). Conclusion: We believe that platelet rich plasma treatment is an effective, reliable, easily applied and low cost application in terms of pain, functional status as well as cartilage regeneration even in patients with advanced osteoarthritis.

Anahtar Kelime:

Konular: Romatoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	TALAY ÇALIŞ H, SÜTBEYAZ TOMRUK S, GÜLER E, HALICI C, SAYAN H, KOÇ A, KONK M, YAZICIOĞLU J (2015). Efficacy of Intra-Articular Autologous Platelet Rich Plasma Application in Knee Osteoarthritis. , 198 - 205.
Chicago	TALAY ÇALIŞ Havva,SÜTBEYAZ TOMRUK Serap,GÜLER Emel,HALICI Canan,SAYAN Hatice,KOÇ ALİ,KONK Metin,YAZICIOĞLU Jülide Aksel Efficacy of Intra-Articular Autologous Platelet Rich Plasma Application in Knee Osteoarthritis. (2015): 198 - 205.
MLA	TALAY ÇALIŞ Havva,SÜTBEYAZ TOMRUK Serap,GÜLER Emel,HALICI Canan,SAYAN Hatice,KOÇ ALİ,KONK Metin,YAZICIOĞLU Jülide Aksel Efficacy of Intra-Articular Autologous Platelet Rich Plasma Application in Knee Osteoarthritis. , 2015, ss.198 - 205.
AMA	TALAY ÇALIŞ H,SÜTBEYAZ TOMRUK S,GÜLER E,HALICI C,SAYAN H,KOÇ A,KONK M,YAZICIOĞLU J Efficacy of Intra-Articular Autologous Platelet Rich Plasma Application in Knee Osteoarthritis. . 2015; 198 - 205.
Vancouver	TALAY ÇALIŞ H,SÜTBEYAZ TOMRUK S,GÜLER E,HALICI C,SAYAN H,KOÇ A,KONK M,YAZICIOĞLU J Efficacy of Intra-Articular Autologous Platelet Rich Plasma Application in Knee Osteoarthritis. . 2015; 198 - 205.
IEEE	TALAY ÇALIŞ H,SÜTBEYAZ TOMRUK S,GÜLER E,HALICI C,SAYAN H,KOÇ A,KONK M,YAZICIOĞLU J "Efficacy of Intra-Articular Autologous Platelet Rich Plasma Application in Knee Osteoarthritis." , ss.198 - 205, 2015.
ISNAD	TALAY ÇALIŞ, Havva vd. "Efficacy of Intra-Articular Autologous Platelet Rich Plasma Application in Knee Osteoarthritis". (2015), 198-205.

APA	TALAY ÇALIŞ H, SÜTBEYAZ TOMRUK S, GÜLER E, HALICI C, SAYAN H, KOÇ A, KONK M, YAZICIOĞLU J (2015). Efficacy of Intra-Articular Autologous Platelet Rich Plasma Application in Knee Osteoarthritis. Archives of Rheumatology, 30(3), 198 - 205.
Chicago	TALAY ÇALIŞ Havva,SÜTBEYAZ TOMRUK Serap,GÜLER Emel,HALICI Canan,SAYAN Hatice,KOÇ ALİ,KONK Metin,YAZICIOĞLU Jülide Aksel Efficacy of Intra-Articular Autologous Platelet Rich Plasma Application in Knee Osteoarthritis. Archives of Rheumatology 30, no.3 (2015): 198 - 205.
MLA	TALAY ÇALIŞ Havva,SÜTBEYAZ TOMRUK Serap,GÜLER Emel,HALICI Canan,SAYAN Hatice,KOÇ ALİ,KONK Metin,YAZICIOĞLU Jülide Aksel Efficacy of Intra-Articular Autologous Platelet Rich Plasma Application in Knee Osteoarthritis. Archives of Rheumatology, vol.30, no.3, 2015, ss.198 - 205.
AMA	TALAY ÇALIŞ H,SÜTBEYAZ TOMRUK S,GÜLER E,HALICI C,SAYAN H,KOÇ A,KONK M,YAZICIOĞLU J Efficacy of Intra-Articular Autologous Platelet Rich Plasma Application in Knee Osteoarthritis. Archives of Rheumatology. 2015; 30(3): 198 - 205.
Vancouver	TALAY ÇALIŞ H,SÜTBEYAZ TOMRUK S,GÜLER E,HALICI C,SAYAN H,KOÇ A,KONK M,YAZICIOĞLU J Efficacy of Intra-Articular Autologous Platelet Rich Plasma Application in Knee Osteoarthritis. Archives of Rheumatology. 2015; 30(3): 198 - 205.
IEEE	TALAY ÇALIŞ H,SÜTBEYAZ TOMRUK S,GÜLER E,HALICI C,SAYAN H,KOÇ A,KONK M,YAZICIOĞLU J "Efficacy of Intra-Articular Autologous Platelet Rich Plasma Application in Knee Osteoarthritis." Archives of Rheumatology, 30, ss.198 - 205, 2015.
ISNAD	TALAY ÇALIŞ, Havva vd. "Efficacy of Intra-Articular Autologous Platelet Rich Plasma Application in Knee Osteoarthritis". Archives of Rheumatology 30/3 (2015), 198-205.