Yıl: 2015 Cilt: 53 Sayı: 1 Sayfa Aralığı: 62 - 66 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Lipid Profile and Inflammation in Degenerative Valvular Disease

Öz:
Aim: Degenerative valvular heart disease (DVHD) may cause serious cardiac problems and mortality. Determination of the factors related to DVHD may render possible the prevention and/or slowing down the progression of DVHD. In this study, we evaluated the relationship of DVHD with lipid profile, microalbuminuria and high sensitive C-reactive protein (hsCRP) levels. Methods: 50 patients (age=65.6±12.4 years) with DVHD were compared with the control group including 20 patients (age=57.3±13.9 years) with left ventricle hypertrophy, but no DVHD. Microalbuminuria, blood lipid parameters and hsCRP levels were measured besides routine biochemical tests. Clinical, laboratory and echocardiographic findings were compared between the groups. Results: Total cholesterol, HDL-cholesterol and LDL-cholesterol levels were significantly higher in DVHD group (215.26±48.59 mg/dL vs. 177.45±22.47 mg/dL, p=0.001; 45.04±11.03 mg/dL vs. 38.90±11.82 mg/dL, p=0.043 and 138.49±40.69 mg/dL vs. 114.26±16.07 mg/dL, p=0.001) compared with control group. hsCRP and microalbuminuria levels were relatively higher in DVHD group. Conclusion: Hyperlipidaemia is related to DHVD development, and the progress of DHVD may be related to the inflammatory process. Elevated hsCRP levels may be an indicator of pathologies active in DVHD development. Routine echocardiographic analysis in hypertensive patients with high hsCRP and LDL-cholesterol levels might be useful for screening of DVHD. (The Me­di­cal Bul­le­tin of Ha­se­ki 2015; 53: 62-6)
Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Dejeneratif Kapak Hastalığında İnflamasyon ve Lipid Profili

Öz:
Amaç: Dejeneratif kalp kapak hastalığı (DKKH) ciddi kardiyak problemlere ve mortaliteye neden olabilir. DKKH ile ilişkili faktörlerin tespit edilmesi DKKH nin önlenmesini ve/veya ilerlemesinin yavaşlatılmasını mümkün kılabilir. Bu çalışmada, DKKH ile lipid profile, mikroalbüminüri ve high sensitive C-reactive protein (hsCRP) düzeylerinin ilişkisini inceledik. Yöntemler: DKKH olan 50 hasta (yaş=65,6±12,4 yıl), sol ventrikül hipertrofisi olup DKKH olmayan 20 hastadan (yaş=57,3±13,9 yıl) oluşan kontrol grubu ile karşılaştırıldı. Hastaların rutin biyokimyasal testler yanında mikroalbuminüri, kan lipid parametreleri ve hsCRP düzeyleri ölçüldü. Grupların klinik, laboratuvar ve ekokardiyografik bulguları karşılaştırıldı. Bulgular: Kontrol grubu ile karşılaştırıldığında DKKH olan grupta total kolesterol, HDL-kolesterol ve LDL-kolesterol düzeyleri anlamlı derecede yüksekti (215,26±48,59 mg/dL vs. 177,45±22,47 mg/dL, p=0,001; 45,04±11,03 mg/dL vs. 38,90±11,82 mg/dL, p=0,043 ve 138,49±40,69 mg/dL vs. 114,26±16,07 mg/dL, p=0,001). hsCRP ve mikroalbüminüri düzeyleri DKKH grubunda daha yüksek idi. Sonuç: Hiperlipidemi DKKH gelişimi ile ilişkilidir, ve DKKH nin ilerlemesi inflamatuvar süreç ile ilişkili olabilir. Yüksek hsCRP düzeyleri DKKH gelişiminde aktif olan patolojilerin bir belirteci olabilir. hsCRP ve LDL-kolesterol düzeyleri yüksek olan hipertansif hastalarda rutin ekokardiyografik inceleme DKKH taraması için yararlı olabilir. (Ha­se­ki T p Bül­te­ni 2015; 53: 62-6)
Anahtar Kelime:

Konular: Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Yamak M, ŞAR F, Akarsu O, Gursu M, HACIOĞLU B, Ataoglu H, KORKMAZ K, OZTÜRK S (2015). Lipid Profile and Inflammation in Degenerative Valvular Disease. , 62 - 66.
Chicago Yamak Mehmet,ŞAR Fuat,Akarsu Ozger,Gursu Meltem,HACIOĞLU Burcu,Ataoglu Hayriye Esra,KORKMAZ Kazım,OZTÜRK SAVAS Lipid Profile and Inflammation in Degenerative Valvular Disease. (2015): 62 - 66.
MLA Yamak Mehmet,ŞAR Fuat,Akarsu Ozger,Gursu Meltem,HACIOĞLU Burcu,Ataoglu Hayriye Esra,KORKMAZ Kazım,OZTÜRK SAVAS Lipid Profile and Inflammation in Degenerative Valvular Disease. , 2015, ss.62 - 66.
AMA Yamak M,ŞAR F,Akarsu O,Gursu M,HACIOĞLU B,Ataoglu H,KORKMAZ K,OZTÜRK S Lipid Profile and Inflammation in Degenerative Valvular Disease. . 2015; 62 - 66.
Vancouver Yamak M,ŞAR F,Akarsu O,Gursu M,HACIOĞLU B,Ataoglu H,KORKMAZ K,OZTÜRK S Lipid Profile and Inflammation in Degenerative Valvular Disease. . 2015; 62 - 66.
IEEE Yamak M,ŞAR F,Akarsu O,Gursu M,HACIOĞLU B,Ataoglu H,KORKMAZ K,OZTÜRK S "Lipid Profile and Inflammation in Degenerative Valvular Disease." , ss.62 - 66, 2015.
ISNAD Yamak, Mehmet vd. "Lipid Profile and Inflammation in Degenerative Valvular Disease". (2015), 62-66.
APA Yamak M, ŞAR F, Akarsu O, Gursu M, HACIOĞLU B, Ataoglu H, KORKMAZ K, OZTÜRK S (2015). Lipid Profile and Inflammation in Degenerative Valvular Disease. Haseki Tıp Bülteni, 53(1), 62 - 66.
Chicago Yamak Mehmet,ŞAR Fuat,Akarsu Ozger,Gursu Meltem,HACIOĞLU Burcu,Ataoglu Hayriye Esra,KORKMAZ Kazım,OZTÜRK SAVAS Lipid Profile and Inflammation in Degenerative Valvular Disease. Haseki Tıp Bülteni 53, no.1 (2015): 62 - 66.
MLA Yamak Mehmet,ŞAR Fuat,Akarsu Ozger,Gursu Meltem,HACIOĞLU Burcu,Ataoglu Hayriye Esra,KORKMAZ Kazım,OZTÜRK SAVAS Lipid Profile and Inflammation in Degenerative Valvular Disease. Haseki Tıp Bülteni, vol.53, no.1, 2015, ss.62 - 66.
AMA Yamak M,ŞAR F,Akarsu O,Gursu M,HACIOĞLU B,Ataoglu H,KORKMAZ K,OZTÜRK S Lipid Profile and Inflammation in Degenerative Valvular Disease. Haseki Tıp Bülteni. 2015; 53(1): 62 - 66.
Vancouver Yamak M,ŞAR F,Akarsu O,Gursu M,HACIOĞLU B,Ataoglu H,KORKMAZ K,OZTÜRK S Lipid Profile and Inflammation in Degenerative Valvular Disease. Haseki Tıp Bülteni. 2015; 53(1): 62 - 66.
IEEE Yamak M,ŞAR F,Akarsu O,Gursu M,HACIOĞLU B,Ataoglu H,KORKMAZ K,OZTÜRK S "Lipid Profile and Inflammation in Degenerative Valvular Disease." Haseki Tıp Bülteni, 53, ss.62 - 66, 2015.
ISNAD Yamak, Mehmet vd. "Lipid Profile and Inflammation in Degenerative Valvular Disease". Haseki Tıp Bülteni 53/1 (2015), 62-66.