TY  - JOUR
TI  - Lipid Profile and Inflammation in Degenerative Valvular Disease
AB  - Aim: Degenerative valvular heart disease (DVHD) may cause serious cardiac problems and mortality. Determination of the factors related to DVHD may render possible the prevention and/or slowing down the progression of DVHD. In this study, we evaluated the relationship of DVHD with lipid profile, microalbuminuria and high sensitive C-reactive protein (hsCRP) levels. Methods: 50 patients (age=65.6±12.4 years) with DVHD were compared with the control group including 20 patients (age=57.3±13.9 years) with left ventricle hypertrophy, but no DVHD. Microalbuminuria, blood lipid parameters and hsCRP levels were measured besides routine biochemical tests. Clinical, laboratory and echocardiographic findings were compared between the groups. Results: Total cholesterol, HDL-cholesterol and LDL-cholesterol levels were significantly higher in DVHD group (215.26±48.59 mg/dL vs. 177.45±22.47 mg/dL, p=0.001; 45.04±11.03 mg/dL vs. 38.90±11.82 mg/dL, p=0.043 and 138.49±40.69 mg/dL vs. 114.26±16.07 mg/dL, p=0.001) compared with control group. hsCRP and microalbuminuria levels were relatively higher in DVHD group. Conclusion: Hyperlipidaemia is related to DHVD development, and the progress of DHVD may be related to the inflammatory process. Elevated hsCRP levels may be an indicator of pathologies active in DVHD development. Routine echocardiographic analysis in hypertensive patients with high hsCRP and LDL-cholesterol levels might be useful for screening of DVHD. (The Me­di­cal Bul­le­tin of Ha­se­ki 2015; 53: 62-6)
AU  - KORKMAZ, Kazım
AU  - Ataoglu, Hayriye Esra
AU  - Gursu, Meltem
AU  - OZTÜRK, SAVAS
AU  - HACIOĞLU, Burcu
AU  - Akarsu, Ozger
AU  - Yamak, Mehmet
AU  - ŞAR, Fuat
PY  - 2015
JO  - Haseki Tıp Bülteni
VL  - 53
IS  - 1
SN  - 1302-0072
SP  - 62
EP  - 66
DB  - TRDizin
UR  - http://search/yayin/detay/178919
ER  -