Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience

ASİL, Talip; İR, Nasıf; UTKU, Ufuk; BALCI, Kemal

Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience

Talip ASİL, (Bezmialem Vakıf Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, İstanbul, Türkiye)

Kemal BALCI, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Samsun, Türkiye)

Ufuk UTKU, (Trakya Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Edirne, Türkiye)

Nasıf İR (Trakya Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Edirne, Türkiye)

Journal of Neurological Sciences (Turkish)

1 0

Yıl: 2011 Cilt: 28 Sayı: 3 Sayfa Aralığı: 317 - 321 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience

Öz:

Amaç: Akut iskemik inmeli hastalarda IV trombolitik tedavi onay alan etkili tek tedavidir. Buçalışmanın amacı akut iskemik inmeli hastalara IV tPA vermeye başladığımız tarihtengünümüze kadar olan süreçte tedavi verdiğimiz hastaların genel bir profilini çıkarmak vetedavi başarısını etkileyen faktörleri incelemektir.Hastalar ve Metodlar: Kliniğimizde IV tPA verdiğimiz akut iskemik inmeli hastalarındemografik verileri, radyolojik ve klinik bulguları kaydedildi. İlk 90 gün içinde olansemptomatik intrakranyal kanamalar ve ölümler kaydedildi. 90. günde 0-2 arası MRS skoruolan hastalar iyi prognozlu, 0-1 olanlar ise çok iyi prognozlu hastalar olarak sınıflandırıldı. Veiyi prognozu etkileyen faktörler incelendi.Bulgular: Kasım 2006- Ocak 2010 arasında 48 akut iskemik inmeli hastaya IV tpa tedavisiverildiği, hastaların yaş ortalamalarının 64,8±12,8, başlangıç NIH skorlarının ortalama16,8±5,2, geliş BT'lerinde hesaplanan ASPECT skorunun ortalama 6,7±2,5 olduğu görüldü.Hastaların 9'u (%18) ilk 90 günde öldü, 2 sinde (%4) ölüme yol açan semptomatikintrakranyal kanama görüldü.. 90. gün MRS skorlarına göre 11 hastanın çok iyi prognozlu(%23), 22 hastanın iyi prognozlu (%46) olduğu görüldü. Başlangıç NIH skorları ve ASPECTskorları ile iyi prognoz arasında bir ilişki olduğu görüldü.Sonuç: Akut iskemik inmeli hastalarda IV tpa tedavisi mortaliteyi azaltmasa da özürlülüğüengelleyen onay almış bir tedavidir. Edirne'deki akut iskemik inmeli hastalardaki IV tPAtedavisi deneyimimizin sonuçları önemli IV tPA çalışmalarının sonuçları ile uyumlu bulundu.

Anahtar Kelime:

Konular: Nörolojik Bilimler

Akut İskemik İnmeli Hastalarda IV tPA Kullanımı: Edirne Deneyimi

Öz:

Objective: Intravenous (IV) thrombolytic therapy is the only approved effective treatmentused in patients with acute ischemic stroke. In this study, we aimed at establishing the clinicaloutcomes of the IV tissue plasminogen activator (tPA) therapy and the main factors affectingthe success rate of the treatment.Patients and Methods: Demographic data, radiological and clinical findings of the patientswith acute ischemic stroke who were administered IV tPA therapy in our clinic wererecorded. During the first 90 days, symptomatic intracranial hemorrhage and death eventswere reported. On day 90, patients were divided into two groups; patients with 0-2 MRSscores were deemed to have a good prognosis, while patients with 0-1 MRS score weredeemed to have an excellent prognosis. The next step was to analyze the factors whichaffected disease prognosis.Results: The study included 48 patients with acute ischemic stroke. Patients wereadministered IV tPA therapy between November 2006 and January 2010. The mean age was64,8±12,8 and the mean NIH score was 16,8±5,2. In addition, the mean ASPECT score was6,7±2,5 based on the baseline CT scan. A total of 9 (18%) of the patients died within the first90 days, including 2 (4%) patients with symptomatic intracranial hemorrhage. On day 90, 11patients (23%) had an excellent prognosis, whereas 22 (46%) had a good prognosis. In thestudy, baseline NIH scores and ASPECT scores were associated with a good prognosis.Conclusion: Intravenous tPA therapy is an approved therapeutic modality in patients withacute ischemic patients, which prevents disability, although it does not decrease mortality.Our study results suggesting that IV tPA therapy was an effective treatment in patients withacute ischemic disease were also consistent with previous significant study findings.

Anahtar Kelime:

Konular: Nörolojik Bilimler

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ASİL T, BALCI K, UTKU U, İR N (2011). Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience. , 317 - 321.
Chicago	ASİL Talip,BALCI Kemal,UTKU Ufuk,İR Nasıf Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience. (2011): 317 - 321.
MLA	ASİL Talip,BALCI Kemal,UTKU Ufuk,İR Nasıf Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience. , 2011, ss.317 - 321.
AMA	ASİL T,BALCI K,UTKU U,İR N Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience. . 2011; 317 - 321.
Vancouver	ASİL T,BALCI K,UTKU U,İR N Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience. . 2011; 317 - 321.
IEEE	ASİL T,BALCI K,UTKU U,İR N "Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience." , ss.317 - 321, 2011.
ISNAD	ASİL, Talip vd. "Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience". (2011), 317-321.

APA	ASİL T, BALCI K, UTKU U, İR N (2011). Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience. Journal of Neurological Sciences (Turkish), 28(3), 317 - 321.
Chicago	ASİL Talip,BALCI Kemal,UTKU Ufuk,İR Nasıf Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience. Journal of Neurological Sciences (Turkish) 28, no.3 (2011): 317 - 321.
MLA	ASİL Talip,BALCI Kemal,UTKU Ufuk,İR Nasıf Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience. Journal of Neurological Sciences (Turkish), vol.28, no.3, 2011, ss.317 - 321.
AMA	ASİL T,BALCI K,UTKU U,İR N Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience. Journal of Neurological Sciences (Turkish). 2011; 28(3): 317 - 321.
Vancouver	ASİL T,BALCI K,UTKU U,İR N Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience. Journal of Neurological Sciences (Turkish). 2011; 28(3): 317 - 321.
IEEE	ASİL T,BALCI K,UTKU U,İR N "Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience." Journal of Neurological Sciences (Turkish), 28, ss.317 - 321, 2011.
ISNAD	ASİL, Talip vd. "Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience". Journal of Neurological Sciences (Turkish) 28/3 (2011), 317-321.