Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats

ÖZKAN, Mazhar; ÇİLİNGİR, Özlem Tuğçe; ARSLANHAN, Ayça; ULUS, AYKAN; ÇELİK, Özgür; ZİYAL, MUSTAFA İBRAHİM; BOZKURT UYAR, Süheyla; Yılmaz Göler, Ayşe Mine

Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats

Aykan ULUS, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Samsun, Türkiye)

Özgür ÇELİK, (Düzce Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Düzce, Türkiye)

Ayça ARSLANHAN, (Marmara Üniversitesi, Tıp Fakültesi, Nörolojik Bilimler Enstitüsü, İstanbul, Türkiye)

Özlem Tuğçe ÇİLİNGİR, (Marmara Üniversitesi, Tıp Fakültesi, Histoloji Embriyoloji Anabilim Dalı, İstanbul, Türkiye)

Mazhar ÖZKAN, (Marmara Üniversitesi, Tıp Fakültesi, Anatomi Anabilim Dalı, İstanbul, Türkiye)

AYŞE MİNE YILMAZ GÖLER, (Marmara Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Süheyla BOZKURT UYAR, (Marmara Üniversitesi,Nörolojik Bilimler Enstitüsü, Nöropatoloji Laboratuvarı, İstanbul, Türkiye)

Mustafa İbrahim ZİYAL (Marmara Üniversitesi, Tıp Fakültesi, Nörolojik Bilimler Enstitüsü, Nöroşirürji Bölümü, İstanbul, Türkiye)

Journal of Neurological Sciences (Turkish)

3 3

Yıl: 2015 Cilt: 32 Sayı: 3 Sayfa Aralığı: 450 - 460 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats

Öz:

Amaç: Subaraknoid kanamalı (SAK) hastalarda sonucu belirleyen major faktörler erkenbeyin hasarı ve serebral vazospazmdır. Bu çalışma zoledronik asidin deneysel SAK modeliyleoluşturulmuş serebral vazospazm üzerine potansiyel tedavi edici etkisini araştırmak amacıylagerçekleştirilmiştir.Metod: Onbeş adet erkek Sprague Dawley rat rastlantısal olarak üç gruba ayrıldı. Grup I'dekiratlara sham operasyonu yapıldı ve işlem sonrası bir tedavi verilmedi (sham grubu,n=5). GrupII'deki ratlara SAK oluşturuldu ve işlem sonrası tedavi verilmedi (SAK grubu, n=5). GrupIII'deki ratlara SAK oluşturuldu ve 2 saat sonra 0.1 mg/kg intraperitoneal zoledronik asidverildi (tedavi grubu, n=5). Ratlar cerrahi işlemler tamamlandıktan 48 saat sonra sakrifiyeedildi. Nörolojik defisit dereceleri, baziller arter vazospazm indeksi, arterial duvar kalınlığı velumen kesit alanları değerlendirildi. Veriler istatistiksel olarak Kruskal-Wallis ve MannWhitney U testleri kullanılarak karşılaştırıldı.Bulgular: Tedavi grubunda ortalama baziller arter vazospazm indeksi ve ortalama arter duvarkalınlığı SAK grubuna göre istatistiksel anlamlı olarak daha az bulundu. Tedavi grubu SAKgrubuna göre istatistiksel olarak anlamlı olmamakla birlikte daha iyi bir fonksiyonel nörolojikiyileşme gösterdi ve baziller arter kesit alanı daha genişti.Sonuç: Bu bulgular ratlarda deneysel SAK modelinde intraperitoneal zoledronik asiduygulamasının vazospazm indeksi ve arterial duvar kalınlığı gibi vazospastik değişiklikleriiyileştirdiğini göstermektedir.

Anahtar Kelime:

Konular: Nörolojik Bilimler

İntraperitoneal Zoledronik Asid Uygulamasının Ratlarda Deneysel Subaraknoid Kanama Modeliyle Oluşturulmuş Serebral Vazospazm Üzerine Etkisi

Öz:

Background: Early brain injury and cerebral vasospasm are major factors determiningoutcome for patients who experience subarachnoid hemorrhage (SAH). This study wasperformed to investigate the potential therapeutic effects of zoledronic acid on cerebralvasospasm in an experimental SAH model.Methods: Fifteen male Sprague Dawley rats were assigned randomly to one of three groups.Animals in Group I were subjected to sham operation and received no treatment after theprocedure (sham group, n=5). Animals in Group II were subjected to SAH and received notreatment after SAH induction (SAH group, n=5). Animals in Group III were subjected toSAH and received 0.1 mg/kg intraperitoneal zoledronic acid injection 2 hours after SAHinduction (treatment group, n=5). Animals were euthanized 48 hours after the surgicalprocedures. Neurological deficit grading, basilar artery vasospasm indices, arterial wallthicknesses, and cross-sectional luminal areas were evaluated. Data were statisticallycompared by Kruskal-Wallis and Mann-Whitney U tests.Results: The treatment group showed a better functional neurological amelioration incomparison to SAH group. However, the difference failed to reach statistical significance. Inthe treatment group, mean basilar artery vasospasm index and mean basilar artery wallthickness were found to be significantly smaller than those of the SAH group, while meanbasilar artery cross-sectional luminal area in the treatment group was insignificantly greaterthan that of the SAH group.Conclusions: These findings revealed that intraperitoneal zoledronic acid administrationattenuated vasospastic changes such as increased vasospasm index and arterial wall thicknessin an experimental rat model of SAH.

Anahtar Kelime:

Konular: Nörolojik Bilimler

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ULUS A, ÇELİK Ö, ARSLANHAN A, ÇİLİNGİR Ö, ÖZKAN M, Yılmaz Göler A, BOZKURT UYAR S, ZİYAL M (2015). Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats. , 450 - 460.
Chicago	ULUS AYKAN,ÇELİK Özgür,ARSLANHAN Ayça,ÇİLİNGİR Özlem Tuğçe,ÖZKAN Mazhar,Yılmaz Göler Ayşe Mine,BOZKURT UYAR Süheyla,ZİYAL MUSTAFA İBRAHİM Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats. (2015): 450 - 460.
MLA	ULUS AYKAN,ÇELİK Özgür,ARSLANHAN Ayça,ÇİLİNGİR Özlem Tuğçe,ÖZKAN Mazhar,Yılmaz Göler Ayşe Mine,BOZKURT UYAR Süheyla,ZİYAL MUSTAFA İBRAHİM Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats. , 2015, ss.450 - 460.
AMA	ULUS A,ÇELİK Ö,ARSLANHAN A,ÇİLİNGİR Ö,ÖZKAN M,Yılmaz Göler A,BOZKURT UYAR S,ZİYAL M Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats. . 2015; 450 - 460.
Vancouver	ULUS A,ÇELİK Ö,ARSLANHAN A,ÇİLİNGİR Ö,ÖZKAN M,Yılmaz Göler A,BOZKURT UYAR S,ZİYAL M Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats. . 2015; 450 - 460.
IEEE	ULUS A,ÇELİK Ö,ARSLANHAN A,ÇİLİNGİR Ö,ÖZKAN M,Yılmaz Göler A,BOZKURT UYAR S,ZİYAL M "Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats." , ss.450 - 460, 2015.
ISNAD	ULUS, AYKAN vd. "Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats". (2015), 450-460.

APA	ULUS A, ÇELİK Ö, ARSLANHAN A, ÇİLİNGİR Ö, ÖZKAN M, Yılmaz Göler A, BOZKURT UYAR S, ZİYAL M (2015). Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats. Journal of Neurological Sciences (Turkish), 32(3), 450 - 460.
Chicago	ULUS AYKAN,ÇELİK Özgür,ARSLANHAN Ayça,ÇİLİNGİR Özlem Tuğçe,ÖZKAN Mazhar,Yılmaz Göler Ayşe Mine,BOZKURT UYAR Süheyla,ZİYAL MUSTAFA İBRAHİM Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats. Journal of Neurological Sciences (Turkish) 32, no.3 (2015): 450 - 460.
MLA	ULUS AYKAN,ÇELİK Özgür,ARSLANHAN Ayça,ÇİLİNGİR Özlem Tuğçe,ÖZKAN Mazhar,Yılmaz Göler Ayşe Mine,BOZKURT UYAR Süheyla,ZİYAL MUSTAFA İBRAHİM Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats. Journal of Neurological Sciences (Turkish), vol.32, no.3, 2015, ss.450 - 460.
AMA	ULUS A,ÇELİK Ö,ARSLANHAN A,ÇİLİNGİR Ö,ÖZKAN M,Yılmaz Göler A,BOZKURT UYAR S,ZİYAL M Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats. Journal of Neurological Sciences (Turkish). 2015; 32(3): 450 - 460.
Vancouver	ULUS A,ÇELİK Ö,ARSLANHAN A,ÇİLİNGİR Ö,ÖZKAN M,Yılmaz Göler A,BOZKURT UYAR S,ZİYAL M Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats. Journal of Neurological Sciences (Turkish). 2015; 32(3): 450 - 460.
IEEE	ULUS A,ÇELİK Ö,ARSLANHAN A,ÇİLİNGİR Ö,ÖZKAN M,Yılmaz Göler A,BOZKURT UYAR S,ZİYAL M "Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats." Journal of Neurological Sciences (Turkish), 32, ss.450 - 460, 2015.
ISNAD	ULUS, AYKAN vd. "Effects of Intraperitoneal Zoledronic Acid Administration on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in Rats". Journal of Neurological Sciences (Turkish) 32/3 (2015), 450-460.