Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population

BAGCI, Hasan; BAYRAKLI, FATİH; ULUS, AYKAN; BAYRİ, Yaşar; TAŞKIN, EMRE; ALTUN, Adnan

Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population

Yaşar BAYRİ, (Marmara Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)

EMRE TAŞKIN, (Karabük Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Karabük, Türkiye)

Aykan ULUS, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Samsun, Türkiye)

Fatih BAYRAKLI, (Marmara Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)

Adnan ALTUN, (Sağlık Bakanlığı, Merzifon Kara Mustafa Paşa Devlet Hastanesi, Nöroşirürji Kliniği, Amasya, Türkiye)

Hasan BAĞCI (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Samsun, Türkiye)

Journal of Neurological Sciences (Turkish)

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Yıl: 2015 Cilt: 32 Sayı: 2 Sayfa Aralığı: 288 - 292 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population

Öz:

Arka plan: IL6 geni bazı hastalık durumları ile ilişkilidir. Literatürde anevrizma oluşumu veanevrizmal SAK ile ilişkisi çalışılmış fakat bildirilen sonuçlar kesin pozitif veya negativebilgi ile sonuçlanmamıştır. Bu çalışmada IL6 gen polimorfizmlerini bir Türk toplumundaincelemeyi ve ilişki anlayışımızı ilerletmeyi amaçladık.Sonuçlar: IL6 geninde yerleşmiş -174 G > C ve -572 G > C promotor polimorfizmlerinigruplar arası genotip farklılığı olup olmadığını incelemek için 120 intrakranyal anevrizmalSAK vakası ve 120 sağlıklı kontrolü dahil ettik. Gruplar arası farklılıklar ki-kare testikullanılarak çalışıldı. Kontroller ile anevrizmal SAK hastaları arasında IL6 promotor 174G >C ve 572G > C polimorfizmleri için istatiksel farklılık yoktu.Netice: IL6 promotor TNPleri Türk toplumunda intrakranyal anevrizma oluşumu vesubaraknoid anevrizma patlaması ile bağlantı göstermemiştir, fakat etnik toplumlar arasındakigenetik farklılıklar farklı sonuçlar verebilir.

Anahtar Kelime:

Konular: Nörolojik Bilimler

Türk Toplumunda İnterlökin 6 Gen Promoter Polimorfizmleri ve Anevrizmal Subaraknoid Kanama Arasındaki İlişki Eksikliği

Öz:

Background: The IL6 gene is related to several disease states. Its relation to aneurysmformation and aneurysmal SAH has been studied in the literature, but the reported results havenot resulted in definite positive or negative data. In this study we aimed to examine IL6 genepolymorphisms in a Turkish population and further our understanding of the relationship.Results: We included 120 intracranial aneurysm SAH cases and 120 healthy controls toexamine whether there was a genotype difference between these groups in the -174 G > C and-572 G > C promoter polymorphisms located in the IL6 gene. The differences between groupswere studied using a chi-squared test. There was no statistical difference between aneurysmalSAH patients and controls for IL6 promoter 174G > C and 572G > C polymorphisms.Conclusions: IL6 promoter SNPs did not show a correlation with intracranial aneurysmformation and subarachnoid aneurysmal rupture in a Turkish population, but geneticdifferences between ethnic populations may give different results.

Anahtar Kelime:

Konular: Nörolojik Bilimler

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BAYRİ Y, TAŞKIN E, ULUS A, BAYRAKLI F, ALTUN A, BAGCI H (2015). Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population. , 288 - 292.
Chicago	BAYRİ Yaşar,TAŞKIN EMRE,ULUS AYKAN,BAYRAKLI FATİH,ALTUN Adnan,BAGCI Hasan Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population. (2015): 288 - 292.
MLA	BAYRİ Yaşar,TAŞKIN EMRE,ULUS AYKAN,BAYRAKLI FATİH,ALTUN Adnan,BAGCI Hasan Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population. , 2015, ss.288 - 292.
AMA	BAYRİ Y,TAŞKIN E,ULUS A,BAYRAKLI F,ALTUN A,BAGCI H Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population. . 2015; 288 - 292.
Vancouver	BAYRİ Y,TAŞKIN E,ULUS A,BAYRAKLI F,ALTUN A,BAGCI H Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population. . 2015; 288 - 292.
IEEE	BAYRİ Y,TAŞKIN E,ULUS A,BAYRAKLI F,ALTUN A,BAGCI H "Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population." , ss.288 - 292, 2015.
ISNAD	BAYRİ, Yaşar vd. "Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population". (2015), 288-292.

APA	BAYRİ Y, TAŞKIN E, ULUS A, BAYRAKLI F, ALTUN A, BAGCI H (2015). Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population. Journal of Neurological Sciences (Turkish), 32(2), 288 - 292.
Chicago	BAYRİ Yaşar,TAŞKIN EMRE,ULUS AYKAN,BAYRAKLI FATİH,ALTUN Adnan,BAGCI Hasan Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population. Journal of Neurological Sciences (Turkish) 32, no.2 (2015): 288 - 292.
MLA	BAYRİ Yaşar,TAŞKIN EMRE,ULUS AYKAN,BAYRAKLI FATİH,ALTUN Adnan,BAGCI Hasan Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population. Journal of Neurological Sciences (Turkish), vol.32, no.2, 2015, ss.288 - 292.
AMA	BAYRİ Y,TAŞKIN E,ULUS A,BAYRAKLI F,ALTUN A,BAGCI H Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population. Journal of Neurological Sciences (Turkish). 2015; 32(2): 288 - 292.
Vancouver	BAYRİ Y,TAŞKIN E,ULUS A,BAYRAKLI F,ALTUN A,BAGCI H Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population. Journal of Neurological Sciences (Turkish). 2015; 32(2): 288 - 292.
IEEE	BAYRİ Y,TAŞKIN E,ULUS A,BAYRAKLI F,ALTUN A,BAGCI H "Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population." Journal of Neurological Sciences (Turkish), 32, ss.288 - 292, 2015.
ISNAD	BAYRİ, Yaşar vd. "Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population". Journal of Neurological Sciences (Turkish) 32/2 (2015), 288-292.