Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas

SAĞER, ÖMER; UYSAL, Bora; OYSUL, Kaan; GAMSIZ, Hakan; BEYZADEOĞLU, MEHMET MURAT; DEMİRAL, Selçuk; DİRİCAN, Bahar; DINCOGLAN, Ferrat; ŞİRİN, Sait; GUNDEM, Esin

Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas

Selçuk DEMİRAL, (Gülhane Askeri Tıp Akademisi Radyasyon Onkolojisi Anabilim Dalı, Ankara, Türkiye)

MEHMET MURAT BEYZADEOĞLU, (Gülhane Askeri Tıp Akademisi Radyasyon Onkolojisi Anabilim Dalı, Ankara, Türkiye)

ÖMER SAĞER, (Gülhane Askeri Tıp Akademisi Radyasyon Onkolojisi Anabilim Dalı, Ankara, Türkiye)

Ferrat DINCOGLAN, (Gülhane Askeri Tıp Akademisi Radyasyon Onkolojisi Anabilim Dalı, Ankara, Türkiye)

Hakan GAMSIZ, (Gülhane Askeri Tıp Akademisi Radyasyon Onkolojisi Anabilim Dalı, Ankara, Türkiye)

Bora UYSAL, (Gülhane Askeri Tıp Akademisi Radyasyon Onkolojisi Anabilim Dalı, Ankara, Türkiye)

Kaan OYSUL, (Gülhane Askeri Tıp Akademisi Radyasyon Onkolojisi Anabilim Dalı, Ankara, Türkiye)

Esin GUNDEM, (Gülhane Askeri Tıp Akademisi Radyasyon Onkolojisi Anabilim Dalı, Ankara, Türkiye)

Bahar DİRİCAN, (Gülhane Askeri Tıp Akademisi Radyasyon Onkolojisi Anabilim Dalı, Ankara, Türkiye)

Sait ŞİRİN (Gülhane Askeri Tıp Akademisi, Tıp Fakültesi Hastanesi, Nöroşirürji Anabilim Dalı, Ankara, Türkiye)

Uluslararası Hematoloji-Onkoloji Dergisi

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Yıl: 2014 Cilt: 24 Sayı: 2 Sayfa Aralığı: 123 - 129 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas

Öz:

Kraniofarinjiyomlar histolojik olarak benign olsalar da rekürrens için güçlü bir eğilimle klinik olarak malign davranış sergileyebilirler. Güncel terapötik yaklaşımlar özellikle tam cerrahi rezeksiyonun uygun olmadığı durumlarda multimodal tedavinin bir parçası olarak stereotaktik radyocerrahi ya da fraksiyone stereotaktik radyoterapi şeklinde stereotaktik ışın tedavisini içermektedir. Bu çalışmada kraniofarinjiyomların multidisipliner manajmanında lineer akseleratör tabanlı stereotaktik radyocerrahinin kullanımı değerlendirilmektedir. Temmuz 1998 ile Temmuz 2013 arasında rezidüel ya da rekürren kraniofarinjiyomlu 20 hasta (11 erkek, 9 kadın) Gülhane Askeri Tıp Akademisi Radyasyon Onkolojisi Departmanında lineer akseleratör tabanlı stereotaktik radyocerrahi kullanılarak tedavi edilmiştir. Medyan yaş 37 (9-69) idi. Medyan tümör volümü 1.1 (0.9-6.9) cc idi. Hedef volümü saran %80-%95 izodoz çizgisine preskribe edilen medyan doz 13 Gy (ranj: 10-16 Gy) idi. Medyan takip süresi 47 (7-93) ay idi. Lokal kontrol oranı 1. yılda %88, 3. yılda %79, 5. yılda %66 idi. 3 ve 5 yıllık progresyonsuz sağkalım oranları sırasıyla %95 ve %91 iken 3 ve 5 yıllık toplam sağkalım oranları sırasıyla %94 ve %88 idi. Çalışmamız rekürren veya rezidüel kraniofarinjiyomlu hastalar için lineer akseleratör tabanlı stereotaktik radyocerrahinin güvenli ve etkin bir manajman stratejisi olarak kullanımını desteklemektedir

Anahtar Kelime:

Konular: Onkoloji

Kraniofarinjiyom Tedavisinde Lineer Akseleratör Tabanlı Stereotaktik Radyocerrahinin Değerlendirilmesi

Öz:

Although benign histologically, craniopharyngiomas may display clinically malignant behavior with a strong propensity for recurrence. Contemporary therapeutic approaches for craniopharyngiomas include stereotactic irradiation in the form of Stereotactic Radiosurgery (SRS) or Fractionated Stereotactic Radiation Therapy (FSRT) as part of multimodality treatment particularly when complete surgical removal is not feasible. In this study, we evaluate the use of Linear Accelerator (LINAC)-based SRS in the multidisciplinary management of patients with craniopharyngiomas. Between July 1998 and July 2013, 20 patients (11 male, 9 female) with residual or recurrent craniopharyngiomas were treated using LINAC-based SRS at Department of Radiation Oncology, Gulhane Military Medical Academy. Median age was 37 (9-69) years. Median tumor volume was 1.1 (0.9-6.9) cc. Median dose was 13 Gy (range: 10-16 Gy) prescribed to the 80%-95% isodose line encompassing the target volume. Median follow-up time was 47 (7-93) months. Overall local control rate was 88% at 1 year, 79% at 3 years and 66% at 5 years. Three and 5-year progression free survival rates were 95% and 91% whereras 3 and 5-year overall survival rates were 94% and 88%, respectively. Our study supports the usage of LINAC-based SRS as a safe and effective management strategy for patients with recurrent or residual craniopharyngiomas

Anahtar Kelime:

Konular: Onkoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	DEMİRAL S, BEYZADEOĞLU M, SAĞER Ö, DINCOGLAN F, GAMSIZ H, UYSAL B, OYSUL K, GUNDEM E, DİRİCAN B, ŞİRİN S (2014). Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas. , 123 - 129.
Chicago	DEMİRAL Selçuk,BEYZADEOĞLU MEHMET MURAT,SAĞER ÖMER,DINCOGLAN Ferrat,GAMSIZ Hakan,UYSAL Bora,OYSUL Kaan,GUNDEM Esin,DİRİCAN Bahar,ŞİRİN Sait Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas. (2014): 123 - 129.
MLA	DEMİRAL Selçuk,BEYZADEOĞLU MEHMET MURAT,SAĞER ÖMER,DINCOGLAN Ferrat,GAMSIZ Hakan,UYSAL Bora,OYSUL Kaan,GUNDEM Esin,DİRİCAN Bahar,ŞİRİN Sait Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas. , 2014, ss.123 - 129.
AMA	DEMİRAL S,BEYZADEOĞLU M,SAĞER Ö,DINCOGLAN F,GAMSIZ H,UYSAL B,OYSUL K,GUNDEM E,DİRİCAN B,ŞİRİN S Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas. . 2014; 123 - 129.
Vancouver	DEMİRAL S,BEYZADEOĞLU M,SAĞER Ö,DINCOGLAN F,GAMSIZ H,UYSAL B,OYSUL K,GUNDEM E,DİRİCAN B,ŞİRİN S Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas. . 2014; 123 - 129.
IEEE	DEMİRAL S,BEYZADEOĞLU M,SAĞER Ö,DINCOGLAN F,GAMSIZ H,UYSAL B,OYSUL K,GUNDEM E,DİRİCAN B,ŞİRİN S "Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas." , ss.123 - 129, 2014.
ISNAD	DEMİRAL, Selçuk vd. "Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas". (2014), 123-129.

APA	DEMİRAL S, BEYZADEOĞLU M, SAĞER Ö, DINCOGLAN F, GAMSIZ H, UYSAL B, OYSUL K, GUNDEM E, DİRİCAN B, ŞİRİN S (2014). Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas. Uluslararası Hematoloji-Onkoloji Dergisi, 24(2), 123 - 129.
Chicago	DEMİRAL Selçuk,BEYZADEOĞLU MEHMET MURAT,SAĞER ÖMER,DINCOGLAN Ferrat,GAMSIZ Hakan,UYSAL Bora,OYSUL Kaan,GUNDEM Esin,DİRİCAN Bahar,ŞİRİN Sait Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas. Uluslararası Hematoloji-Onkoloji Dergisi 24, no.2 (2014): 123 - 129.
MLA	DEMİRAL Selçuk,BEYZADEOĞLU MEHMET MURAT,SAĞER ÖMER,DINCOGLAN Ferrat,GAMSIZ Hakan,UYSAL Bora,OYSUL Kaan,GUNDEM Esin,DİRİCAN Bahar,ŞİRİN Sait Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas. Uluslararası Hematoloji-Onkoloji Dergisi, vol.24, no.2, 2014, ss.123 - 129.
AMA	DEMİRAL S,BEYZADEOĞLU M,SAĞER Ö,DINCOGLAN F,GAMSIZ H,UYSAL B,OYSUL K,GUNDEM E,DİRİCAN B,ŞİRİN S Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas. Uluslararası Hematoloji-Onkoloji Dergisi. 2014; 24(2): 123 - 129.
Vancouver	DEMİRAL S,BEYZADEOĞLU M,SAĞER Ö,DINCOGLAN F,GAMSIZ H,UYSAL B,OYSUL K,GUNDEM E,DİRİCAN B,ŞİRİN S Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas. Uluslararası Hematoloji-Onkoloji Dergisi. 2014; 24(2): 123 - 129.
IEEE	DEMİRAL S,BEYZADEOĞLU M,SAĞER Ö,DINCOGLAN F,GAMSIZ H,UYSAL B,OYSUL K,GUNDEM E,DİRİCAN B,ŞİRİN S "Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas." Uluslararası Hematoloji-Onkoloji Dergisi, 24, ss.123 - 129, 2014.
ISNAD	DEMİRAL, Selçuk vd. "Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas". Uluslararası Hematoloji-Onkoloji Dergisi 24/2 (2014), 123-129.