Acute in Vitro effects of ABS (Ankaferd Hemostat) on the Lymphoid Neoplastic Cells (B-CLL and RAJI Tumor Cell Lines)
Yıl: 2014 Cilt: 24 Sayı: 4 Sayfa Aralığı: 253 - 259 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
Acute in Vitro effects of ABS (Ankaferd Hemostat) on the Lymphoid Neoplastic Cells (B-CLL and RAJI Tumor Cell Lines)
Öz: ABS (Ankaferd Hemostat) yeni bir bitki kaynaklı hemostatik ajan olarak ortaya çıkmıştır. ABSin, özellikle tümör ilişkili transkripsiyon faktörleri olmak üzere hücre yüzeyi reseptörleri ve/veya kan proteinleri ile doku proteinleri gibi birçok protein ile etkileşebilmesi biolojik sistemlerde yeni fonksiyonlarını ortaya çıkarmıştır. Bu nedenle, bu çalışmamızda ABSin lenfoid neoplastik hücreler üzerindeki etkilerini araştırmayı amaçladık. Ankaferd ile (0.5, 1 ve 2 µg/mL dozlarında) muamele edilen B-KLL hücrelerinin şişmesinin durduğu ve 0.1 ile 0.25 µg/mL dozlarına kıyasla %50den fazla tümör hücresinin öldüğünü gösterdik. Ek olarak, kültür ortamına Ankaferd eklenmesi ile B-KLL hücrelerinin blastik agresif lenfoid forma dönüşümü engellendi. Bu sonuçlar, yüksek dozlarda (>0.5 µg/mL) antineoplastik etkileri, düşük dozlarda (<0.5 µg/mL) ise hücresel farklılaşmanın uyarıldığının ipuçlarını vererek neoplastik kanamaların tedavisinde öncül gelişmeler sundu.
Anahtar Kelime: Konular:
Ankaferd Hemostat (ABS) nin Lenfoid Neoplastik Hücreler (B-CLL ve RAJI Tümör Hücre dizileri) Üzerine Akut in vitro Etkileri
Öz: ABS (Ankaferd Hemostat) has emerged as a novel haemostatic agent of plant origin. Its ability to interact with entire proteins including cell surface receptors and/or blood proteins plus tissue proteins revealed novel functions of ABS to biologic systems especially tumor associated transcription factors. Thus, in our study, we aimed to investigate the effects of ABS on lymphoid neoplastic cells in vitro. We showed that Ankaferd treated B-CLL cells (at doses 0.5, 1 and 2 µg/mL) ceased to inflate and more than 50% of tumor cells were died compared to 0.1 and 0.25 µg/mL doses. Additionally, transformation of B-CLL cells to the blastic aggressive lymphoid forms was prevented by addition of Ankaferd to culture medium. The results have given the clues of anti-neoplastic effects at higher doses (>0.5 µg/mL) and induction of cellular differentiation at lower doses (<0.5 µg/mL) and proposed future advances in treatment of neoplastic bleedings.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | AKALIN İ, OKUR F, HAZNEDAROĞLU İ, Sayınalp N, AKSU S, BÜYÜKAŞIK Y, GOKER A (2014). Acute in Vitro effects of ABS (Ankaferd Hemostat) on the Lymphoid Neoplastic Cells (B-CLL and RAJI Tumor Cell Lines). , 253 - 259. |
| Chicago | AKALIN İbrahim,OKUR Fatma V.,HAZNEDAROĞLU İbrahim C.,Sayınalp Nilgün,AKSU SALIH,BÜYÜKAŞIK Yahya,GOKER ALI HAKAN Acute in Vitro effects of ABS (Ankaferd Hemostat) on the Lymphoid Neoplastic Cells (B-CLL and RAJI Tumor Cell Lines). (2014): 253 - 259. |
| MLA | AKALIN İbrahim,OKUR Fatma V.,HAZNEDAROĞLU İbrahim C.,Sayınalp Nilgün,AKSU SALIH,BÜYÜKAŞIK Yahya,GOKER ALI HAKAN Acute in Vitro effects of ABS (Ankaferd Hemostat) on the Lymphoid Neoplastic Cells (B-CLL and RAJI Tumor Cell Lines). , 2014, ss.253 - 259. |
| AMA | AKALIN İ,OKUR F,HAZNEDAROĞLU İ,Sayınalp N,AKSU S,BÜYÜKAŞIK Y,GOKER A Acute in Vitro effects of ABS (Ankaferd Hemostat) on the Lymphoid Neoplastic Cells (B-CLL and RAJI Tumor Cell Lines). . 2014; 253 - 259. |
| Vancouver | AKALIN İ,OKUR F,HAZNEDAROĞLU İ,Sayınalp N,AKSU S,BÜYÜKAŞIK Y,GOKER A Acute in Vitro effects of ABS (Ankaferd Hemostat) on the Lymphoid Neoplastic Cells (B-CLL and RAJI Tumor Cell Lines). . 2014; 253 - 259. |
| IEEE | AKALIN İ,OKUR F,HAZNEDAROĞLU İ,Sayınalp N,AKSU S,BÜYÜKAŞIK Y,GOKER A "Acute in Vitro effects of ABS (Ankaferd Hemostat) on the Lymphoid Neoplastic Cells (B-CLL and RAJI Tumor Cell Lines)." , ss.253 - 259, 2014. |
| ISNAD | AKALIN, İbrahim vd. "Acute in Vitro effects of ABS (Ankaferd Hemostat) on the Lymphoid Neoplastic Cells (B-CLL and RAJI Tumor Cell Lines)". (2014), 253-259. |
| APA | AKALIN İ, OKUR F, HAZNEDAROĞLU İ, Sayınalp N, AKSU S, BÜYÜKAŞIK Y, GOKER A (2014). Acute in Vitro effects of ABS (Ankaferd Hemostat) on the Lymphoid Neoplastic Cells (B-CLL and RAJI Tumor Cell Lines). Uluslararası Hematoloji-Onkoloji Dergisi, 24(4), 253 - 259. |
| Chicago | AKALIN İbrahim,OKUR Fatma V.,HAZNEDAROĞLU İbrahim C.,Sayınalp Nilgün,AKSU SALIH,BÜYÜKAŞIK Yahya,GOKER ALI HAKAN Acute in Vitro effects of ABS (Ankaferd Hemostat) on the Lymphoid Neoplastic Cells (B-CLL and RAJI Tumor Cell Lines). Uluslararası Hematoloji-Onkoloji Dergisi 24, no.4 (2014): 253 - 259. |
| MLA | AKALIN İbrahim,OKUR Fatma V.,HAZNEDAROĞLU İbrahim C.,Sayınalp Nilgün,AKSU SALIH,BÜYÜKAŞIK Yahya,GOKER ALI HAKAN Acute in Vitro effects of ABS (Ankaferd Hemostat) on the Lymphoid Neoplastic Cells (B-CLL and RAJI Tumor Cell Lines). Uluslararası Hematoloji-Onkoloji Dergisi, vol.24, no.4, 2014, ss.253 - 259. |
| AMA | AKALIN İ,OKUR F,HAZNEDAROĞLU İ,Sayınalp N,AKSU S,BÜYÜKAŞIK Y,GOKER A Acute in Vitro effects of ABS (Ankaferd Hemostat) on the Lymphoid Neoplastic Cells (B-CLL and RAJI Tumor Cell Lines). Uluslararası Hematoloji-Onkoloji Dergisi. 2014; 24(4): 253 - 259. |
| Vancouver | AKALIN İ,OKUR F,HAZNEDAROĞLU İ,Sayınalp N,AKSU S,BÜYÜKAŞIK Y,GOKER A Acute in Vitro effects of ABS (Ankaferd Hemostat) on the Lymphoid Neoplastic Cells (B-CLL and RAJI Tumor Cell Lines). Uluslararası Hematoloji-Onkoloji Dergisi. 2014; 24(4): 253 - 259. |
| IEEE | AKALIN İ,OKUR F,HAZNEDAROĞLU İ,Sayınalp N,AKSU S,BÜYÜKAŞIK Y,GOKER A "Acute in Vitro effects of ABS (Ankaferd Hemostat) on the Lymphoid Neoplastic Cells (B-CLL and RAJI Tumor Cell Lines)." Uluslararası Hematoloji-Onkoloji Dergisi, 24, ss.253 - 259, 2014. |
| ISNAD | AKALIN, İbrahim vd. "Acute in Vitro effects of ABS (Ankaferd Hemostat) on the Lymphoid Neoplastic Cells (B-CLL and RAJI Tumor Cell Lines)". Uluslararası Hematoloji-Onkoloji Dergisi 24/4 (2014), 253-259. |
