Purpose : To evaluate central serous chorioretinopathy (CSCR) with optical coherence tomography (OCT) during the acute and resolution phase. Method : 12 patients (8 men and 4 women) who were examined between October 2000 and May 2001 and diagnosed as CSCR were included in the study. Complete ophthalmologic examination was performed, color fundus photographs were taken and optical coherence tomography was performed. Fundus fluorescein angiography was performed in all cases except two pregnant women during initial examination. FA and OCT were repeated during the control examinations. The difference between the retinal thickness and serous elevation during the acute and resolution phase in cross-sectional images obtained by OCT were evaluated. Results : 14 eyes of 12 patients had on acute phase of CSCR according to fundus examination and fluorescein angiography. 2 patients were pregnant and one of them had bilateral involvement. Fluorescein angiography was not performed in these cases. Fluorescein angiograhy revealed one or more leakage points in 10 eyes, multiple pigment epithelial detachments (PED) in one eye. OCT scans showed neurosensory retinal detachment and increased retinal thickness in 13 eyes, and PED's in one eye. PED in a pregnant woman was detected by OCT. During follow-up period, in the eyes without active leakage point in fluorescein angiography, the neurosensory detachments resolved and retinal thickness decreased in OCT scans. Conclusion : OCT is a usefull and objective diagnostic technique in evaluating PED, neurosensory retinal detachment and retinal thickness in CSCR. It may be an alternative diagnostic tool in pregnant women. Ret-vit 2001; 10 :148 -155.