Ketamine Infusion in Treatment Resistant Depression: A Case Report and Brief Review of The Literature

HIZLI SAYAR, Feride Gökben; ÖZTEN, Eylem; SAVAŞ, A. Haluk

Ketamine Infusion in Treatment Resistant Depression: A Case Report and Brief Review of The Literature

Feride Gökben HIZLI SAYAR, (Üsküdar Üniversitesi, Nöropsikiyatri Hastanesi, İstanbul, Türkiye)

Eylem ÖZTEN, (Üsküdar Üniversitesi, Nöropsikiyatri Hastanesi, İstanbul, Türkiye)

A. Haluk SAVAŞ (Gaziantep Üniversitesi, Tıp Fakültesi, Psikiyatri Bölümü, Gaziantep, Türkiye)

Journal of Mood Disorders

26 0

Yıl: 2015 Cilt: 5 Sayı: 2 Sayfa Aralığı: 78 - 82 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Ketamine Infusion in Treatment Resistant Depression: A Case Report and Brief Review of The Literature

Öz:

Glutamat N-metil-D-aspartat reseptör antagonisti olanketamin antidepresan etkinlik gösterebilmektedir.Tedaviye dirençli depresyon olgularında yürütülmüş olanaraştırmalarda ketamin infüzyonu hızlı başlangıçlı ve birkaçgün süren bir antidepresan etkinlik göstermiştir. Bu olgusunumunda intravenöz ketamin uygulaması sonrası tekuçlu depresif dönemde belirtilerde ve intihar düşüncesindehızlı yatışma izlenmiştir. Mevcut antidepresanların etkibaşlangıcı için uzun süre gerektirmesi nedeniyle akut veşiddetli intihar düşüncesinin klinik tedavisinde yakın izlemveya hastaneye yatırma dışında çok az seçenek vardır.Ketaminin hızlı etkinliği intihar riski yüksek hastaların elealınmasında bir avantaj sağlayabilir. Ketaminin optimaldoz ve uygulama yollarının belirlenmesi için çalışmalargerekli olmakla birlikte, NMDA üzerine etkili ajanlar dirençli depresyon tedavisi ve intihar riskinin azaltılması için birseçenek olarak daha fazla araştırmayı hak etmektedir.

Anahtar Kelime:

Konular: Psikiyatri

Tedaviye dirençli depresyonda ketamin infüzyonu: Bir vaka sunumu ve literatürün kısa gözden geçirilmesi

Öz:

The glutamate N-methyl-D-aspartate (NMDA) receptorantagonist ketamine may exhibit antidepressant effect.Previous studies of treatment-resistant depression revealthat ketamine infusions may result in a rapid antidepressantresponse with improvement usually sustained for severaldays. This case suggests that intravenous administrationof ketamine may be effective for immediate relief fromsymptoms in unipolar depression and may also relievesuicidal ideation. Due to the prolonged period between theinitiation of treatment and the onset of action of currentlyavailable antidepressants, only a few things can be donefor the management of acute and severe suicidal ideationother than close monitoring or hospitalization. Rapid effectof ketamine may be an advantage in the managementof suicide risk. Although additional research is neededto ascertain optimal dosing schedules and route ofadministration of ketamine, NMDA agents warrant furtherinvestigation as a treatment option in treatment-resistantdepression and as an agent intended to reduce suicides.

Anahtar Kelime:

Konular: Psikiyatri

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık

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APA	HIZLI SAYAR F, ÖZTEN E, SAVAŞ A (2015). Ketamine Infusion in Treatment Resistant Depression: A Case Report and Brief Review of The Literature. , 78 - 82.
Chicago	HIZLI SAYAR Feride Gökben,ÖZTEN Eylem,SAVAŞ A. Haluk Ketamine Infusion in Treatment Resistant Depression: A Case Report and Brief Review of The Literature. (2015): 78 - 82.
MLA	HIZLI SAYAR Feride Gökben,ÖZTEN Eylem,SAVAŞ A. Haluk Ketamine Infusion in Treatment Resistant Depression: A Case Report and Brief Review of The Literature. , 2015, ss.78 - 82.
AMA	HIZLI SAYAR F,ÖZTEN E,SAVAŞ A Ketamine Infusion in Treatment Resistant Depression: A Case Report and Brief Review of The Literature. . 2015; 78 - 82.
Vancouver	HIZLI SAYAR F,ÖZTEN E,SAVAŞ A Ketamine Infusion in Treatment Resistant Depression: A Case Report and Brief Review of The Literature. . 2015; 78 - 82.
IEEE	HIZLI SAYAR F,ÖZTEN E,SAVAŞ A "Ketamine Infusion in Treatment Resistant Depression: A Case Report and Brief Review of The Literature." , ss.78 - 82, 2015.
ISNAD	HIZLI SAYAR, Feride Gökben vd. "Ketamine Infusion in Treatment Resistant Depression: A Case Report and Brief Review of The Literature". (2015), 78-82.

APA	HIZLI SAYAR F, ÖZTEN E, SAVAŞ A (2015). Ketamine Infusion in Treatment Resistant Depression: A Case Report and Brief Review of The Literature. Journal of Mood Disorders, 5(2), 78 - 82.
Chicago	HIZLI SAYAR Feride Gökben,ÖZTEN Eylem,SAVAŞ A. Haluk Ketamine Infusion in Treatment Resistant Depression: A Case Report and Brief Review of The Literature. Journal of Mood Disorders 5, no.2 (2015): 78 - 82.
MLA	HIZLI SAYAR Feride Gökben,ÖZTEN Eylem,SAVAŞ A. Haluk Ketamine Infusion in Treatment Resistant Depression: A Case Report and Brief Review of The Literature. Journal of Mood Disorders, vol.5, no.2, 2015, ss.78 - 82.
AMA	HIZLI SAYAR F,ÖZTEN E,SAVAŞ A Ketamine Infusion in Treatment Resistant Depression: A Case Report and Brief Review of The Literature. Journal of Mood Disorders. 2015; 5(2): 78 - 82.
Vancouver	HIZLI SAYAR F,ÖZTEN E,SAVAŞ A Ketamine Infusion in Treatment Resistant Depression: A Case Report and Brief Review of The Literature. Journal of Mood Disorders. 2015; 5(2): 78 - 82.
IEEE	HIZLI SAYAR F,ÖZTEN E,SAVAŞ A "Ketamine Infusion in Treatment Resistant Depression: A Case Report and Brief Review of The Literature." Journal of Mood Disorders, 5, ss.78 - 82, 2015.
ISNAD	HIZLI SAYAR, Feride Gökben vd. "Ketamine Infusion in Treatment Resistant Depression: A Case Report and Brief Review of The Literature". Journal of Mood Disorders 5/2 (2015), 78-82.