Objective: In our study, we evaluated the clinical character- istics and outcomes of treatment in patients with Kaposi ssarcoma (KS). Methods: The patients undergoing radiotherapy (RT) be- cause of the KS between the years 2005-2012 in RadiationOncology Department of Dicle University Hospital were in- cluded. All patients underwent RT with different dose-frac- tionation schemes to increase quality of life and to palliatethe symptoms. Patients with lesions in multiple regions un- derwent RT in the same or different dates. Responses toradiotherapy were recorded as complete or partial response.Results: Fourteen patients received radiotherapy becauseof f KS were evaluated retrospectively. Twenty two differ- ent regions of 14 patients underwent RT . Only one patient(4.5%) was performed RT to glans penis as a third regionwhile performed to the two regions in six patients (27.3%). Atirradiations, 6 MV and 10 MV photon energies with 6 MeV, 9MeV and 12 MeV electron energy were used. Water phan- tom or bolus material was used to obtain a homogeneousdose distribution in the photon irradiation. RT dose adminis- tered to a total of 22 different regional was median 800 cGy(Range: 800-3000 cGy). Median number of RT fractions was1 (Range: 1-10). When treatment response were evaluated stable diseasewas present in the 4 (18.1%) regions. Partial response wasachieved in eight (36.4%) regions, complete response in 10(45.5%). RT-related common lymphedema in the feet andlegs was observed in the four (57.3%) regions in the acuteperiod. Complication of pain was present in two (28.7%) re- gions. Conclusion: RT is an appropriate and effective treatmentregimen in the palliative treatment of KS lesions. Excellentresponse rates of skin lesions may be obtained by RT. Le- sions and symptoms such as itching may be lost after RT.Side effects such as edema and pain may be relieved bysupportive treatment.