The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome

GÜNBATAR, Hülya; ÇİLİNGİR MERMİT, Buket; Ekin, Selami; SÜNNETCİOĞLU, Aysel; ARISOY, Ahmet; AŞKER, SELVİ; Sertogullarindan, Bunyamin

The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome

Hülya GÜNBATAR, (Yüzüncü Yıl Üniversitesi, Dursun Odabaş Tıp Merkezi, Göğüs Hastalıkları Anabilim Dalı, Van, Türkiye)

Buket ÇİLİNGİR MERMİT, (Bölge Eğitim ve Araştırma Hastanesi, Göğüs Cerrahisi Kliniği, Van, Türkiye)

Selami EKİN, (Yüzüncü Yıl Üniversitesi, Dursun Odabaş Tıp Merkezi, Göğüs Hastalıkları Anabilim Dalı, Van, Türkiye)

Aysel SÜNNETCİOĞLU, (Yüzüncü Yıl Üniversitesi, Dursun Odabaş Tıp Merkezi, Göğüs Hastalıkları Anabilim Dalı, Van, Türkiye)

Ahmet ARISOY, (Yüzüncü Yıl Üniversitesi, Dursun Odabaş Tıp Merkezi, Göğüs Hastalıkları Anabilim Dalı, Van, Türkiye)

Selvi AŞKER, (Yüzüncü Yıl Üniversitesi, Dursun Odabaş Tıp Merkezi, Göğüs Hastalıkları Anabilim Dalı, Van, Türkiye)

Bünyamin SERTOĞULLARINDAN (Yüzüncü Yıl Üniversitesi, Dursun Odabaş Tıp Merkezi, Göğüs Hastalıkları Anabilim Dalı, Van, Türkiye)

Dicle Tıp Dergisi

2 0

Yıl: 2015 Cilt: 42 Sayı: 3 Sayfa Aralığı: 289 - 293 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome

Öz:

Amaç: Obstruktif Uyku Apne Sendromu (OSAS) ile Kardi- yovasküler Hastalıklar (KVH) arasında güçlü bir ilişki var- dır. Kronik intermittan hipoksi, inflamasyon, oksidatif stresve endotelyal disfonksiyon OSAS ve KVH arasındaki et- yolojik mekanizmaları ortaya çıkarmış olabilir. İnflamas- yon KVH gelişiminde önemli rol oynar. Platelet LenfositOranı (PLO) ve Nötrofil Lenfosit Oranı (NLO) inflamasyo- nu gösteren yeni belirteçlerdir. Bu çalışma PLO ve NLOarasındaki ilişkiyi ve OSAS şiddeti, polisomnografik para- metreler ve PLR arasındaki ilişkiyi araştırmaktadır.Yöntemler: OSAS ön tanısı ile tüm gece polisomnografisiyapılan hastaların çalışmaya dahil edildiği bir kohort çalış- ması planlandı. Hastalar apne hipopne indeksi skorlarınagöre sınıflandırıldı. Basit horlama (Grup 1; AHİ <5 adet/ saat), hafif OSAS (Grup 2; AHİ: 5-15), orta derece OSAS(Grup 3; AHİ: 15-30) ve ağrı OSAS (Grup 4; AHİ >30).Bulgular: 111 hasta çalışmaya dahil edildi. Grup 1, 2 ve3 te sırasıyla 26, 22 ve 63 hasta vardı. PLO gruplar ara- sında anlamlı düzeyde değişiklik göstermekteydi. Grup1de 87,12, Grup2de 103,6, Grup 3te 112,5 idi (p < 0.05).PLO ile NLO, AHİ, oksi jen desaturasyon indeksi, ortalamave minimum oksi jen saturasyon değeri arasında anlamlıderecede ilişki vardı (p<0.05). Çoklu regresyon analizi ilePLO nun KVH için bağımsız bir belirleyici olduğu saptan- dı. KVH varlığında, PLO cut off değerinin 86,03 olduğugösterildi.Sonuç: Tüm bu bulgular ışığında PLO ile OSAS şiddetiarasında güçlü ilişki vardır. PLO OSAS hastalarında KVHvarlığını belirlemede bir belirteç olarak kullanılabilir

Anahtar Kelime:

Konular: Cerrahi

Obstruktif uyku apne sendromunda platelet lenfosit oranı ve nötrofil lenfosit oranı ilişkisi

Öz:

Objective: There is a strong relationship between ob- structive sleep apnea syndrome (OSAS) and cardiovas- cular disease (CVD). Chronic intermittent hypoxia, inflam- mation, oxidative stress, and endothelial dysfunction maycreate etiologic mechanisms, connection between OSASto CVD. Inflammation play an important role in the devel- opment of CVD. Platelet- Lymphocyte Ratio (PLR) andNeutrophil-lymphocyte Ratio (NLR) are new biomarkersshowing inflammation. This study was designed to inves- tigate the association between PLR, NLR and relationshipbetween severity of OSAS, polysomnographic param- eters and PLR.Methods: This was a cohort study in which patients whohad undergone a full night polysomnography for diagnosisof OSA were recruited. Patients were divided according totheir apnea hypopnea index (AHI) scores into OSAS neg- ative simple snoring (Group 1; AHI <5 times/hours), mild(Group 2; AHI: 5-15), moderate (Group 3; AHI:15-30), andsevere OSAS (Group 4; AHI >30) groups.Results: A total of 111 patients were included in thisstudy. There were 26, 22 and 63 patients in Groups 1, 2and 3, respectively. PLR were significantly different be- tween groups (Group 1: 87.12, Group 2: 103.6, Group 3:112.5, p < 0.05). PLR were significantly correlated withNLR, AHI, oxygen desaturation index, average and mini- mum O2 saturation values (p < 0.05). Multiple regressionanalysis demonstrated that PLR is an independent pre- dictor of CVD. PLR cut-off value for demonstrating thepresence of CVD is higher than 86.03.Conclusion: In the light of these findings, PLR is stronglyassociated with the severity of OSAS. PLR might be usedas a biomarker to predict CVD in OSAS patients.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

TRDizin Dışındaki Atıf Sayıları

OpenCitations: 0

OpenAlex: 0

Crossref: 0

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APA	GÜNBATAR H, ÇİLİNGİR MERMİT B, Ekin S, SÜNNETCİOĞLU A, ARISOY A, AŞKER S, Sertogullarindan B (2015). The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome. , 289 - 293.
Chicago	GÜNBATAR Hülya,ÇİLİNGİR MERMİT Buket,Ekin Selami,SÜNNETCİOĞLU Aysel,ARISOY Ahmet,AŞKER SELVİ,Sertogullarindan Bunyamin The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome. (2015): 289 - 293.
MLA	GÜNBATAR Hülya,ÇİLİNGİR MERMİT Buket,Ekin Selami,SÜNNETCİOĞLU Aysel,ARISOY Ahmet,AŞKER SELVİ,Sertogullarindan Bunyamin The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome. , 2015, ss.289 - 293.
AMA	GÜNBATAR H,ÇİLİNGİR MERMİT B,Ekin S,SÜNNETCİOĞLU A,ARISOY A,AŞKER S,Sertogullarindan B The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome. . 2015; 289 - 293.
Vancouver	GÜNBATAR H,ÇİLİNGİR MERMİT B,Ekin S,SÜNNETCİOĞLU A,ARISOY A,AŞKER S,Sertogullarindan B The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome. . 2015; 289 - 293.
IEEE	GÜNBATAR H,ÇİLİNGİR MERMİT B,Ekin S,SÜNNETCİOĞLU A,ARISOY A,AŞKER S,Sertogullarindan B "The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome." , ss.289 - 293, 2015.
ISNAD	GÜNBATAR, Hülya vd. "The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome". (2015), 289-293.

APA	GÜNBATAR H, ÇİLİNGİR MERMİT B, Ekin S, SÜNNETCİOĞLU A, ARISOY A, AŞKER S, Sertogullarindan B (2015). The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome. Dicle Tıp Dergisi, 42(3), 289 - 293.
Chicago	GÜNBATAR Hülya,ÇİLİNGİR MERMİT Buket,Ekin Selami,SÜNNETCİOĞLU Aysel,ARISOY Ahmet,AŞKER SELVİ,Sertogullarindan Bunyamin The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome. Dicle Tıp Dergisi 42, no.3 (2015): 289 - 293.
MLA	GÜNBATAR Hülya,ÇİLİNGİR MERMİT Buket,Ekin Selami,SÜNNETCİOĞLU Aysel,ARISOY Ahmet,AŞKER SELVİ,Sertogullarindan Bunyamin The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome. Dicle Tıp Dergisi, vol.42, no.3, 2015, ss.289 - 293.
AMA	GÜNBATAR H,ÇİLİNGİR MERMİT B,Ekin S,SÜNNETCİOĞLU A,ARISOY A,AŞKER S,Sertogullarindan B The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome. Dicle Tıp Dergisi. 2015; 42(3): 289 - 293.
Vancouver	GÜNBATAR H,ÇİLİNGİR MERMİT B,Ekin S,SÜNNETCİOĞLU A,ARISOY A,AŞKER S,Sertogullarindan B The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome. Dicle Tıp Dergisi. 2015; 42(3): 289 - 293.
IEEE	GÜNBATAR H,ÇİLİNGİR MERMİT B,Ekin S,SÜNNETCİOĞLU A,ARISOY A,AŞKER S,Sertogullarindan B "The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome." Dicle Tıp Dergisi, 42, ss.289 - 293, 2015.
ISNAD	GÜNBATAR, Hülya vd. "The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome". Dicle Tıp Dergisi 42/3 (2015), 289-293.