Objective: Obesity remains an increasing public healthand socioeconomic problem. Life style changes includinghealthy diet and physical activity are the first-line therapyfor successful weight loss. The intragastric balloon hasbeen considered as an effective and reversible, non-sur- gical method for weight loss. In this study, we aimed toinvestigate the effects of Intragastric balloon on weightloss, lipid profiles and blood glucose regulation in obesepatientsMethods: 75 consecutive Intragastric balloon patients(55 Female, 20 Male) with a mean age of 35.2±9.6 yearswere included in this study. The study was conductedprospectively and an air-filled intragastric balloon wasintroduced in ambulatory settings. In this study, patientspre-intervention body mass index, peripheral blood pa- rameters such as HbA1c, lipid profiles were recorded andcompared with post-intervention values. Results: The median intervention time for intragastricballoon application was 13 min (8-19). After follow-upperiod of median 186 days (180-211), BMI was reducedsignificantly, 41.6±6.7 vs. 34.9±6.4 kg/m2(p<0.001). Themedian excess weight loss was found to be 33.2% (14- 81.1). There is no statistically significant difference be- tween pre-intervention and post-intervention valuables interms of low-density lipoprotein, high-density lipoprotein,cholesterol and triglycerides levels (p>0.05). On the otherhand, only pre and post-intervention HbA1c level was tobe statistically significant (p=0.001) Conclusion: There was significant change in BMI andHbA1c level with the intervention of intragastric balloonafter follow-up period. For long-term benefit of balloon,further studies are needed.