Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats

Mehmet MÜFİT ORAK, (Fatih Sultan Mehmet Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Kliniği, İstanbul, Türkiye)
Dursun AK, (Fatih Sultan Mehmet Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Kliniği, İstanbul, Türkiye)
Ahmet MİDİ, (Fatih Sultan Mehmet Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Kliniği, İstanbul, Türkiye)
Berna LAÇİN, (Fatih Sultan Mehmet Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Kliniği, İstanbul, Türkiye)
Sevim PURİSA, (Fatih Sultan Mehmet Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Kliniği, İstanbul, Türkiye)
Güven BULUT (Fatih Sultan Mehmet Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Kliniği, İstanbul, Türkiye)
Acta Orthopaedica et Traumatologica Turcica
6 0
Yıl: 2015 Cilt: 49 Sayı: 4 Sayfa Aralığı: 438 - 446 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats

Öz:
Objective: Lyophilized drug manufacturing and intra-articular (IA) applications have increased to address gastrointestinal side effects resulting from chronic treatment with non-steroidal anti-inflammatory drugs (NSAIDs) for degenerative joint disease. Accordingly, we histologically examined joint and stomach tissues from rats to determine and compare the effects of long-term treatment with an IA corticosteroid (methylprednisolone acetate), lyophilized NSAID (tenoxicam), and non-lyophilized NSAID (diclofenac) following application to the knee joint.Methods: One hundred Wistar albino rats were divided into 4 groups of 25 rats: control, methylprednisolone, tenoxicam, and diclofenac. Ten IA injections were administered at 1-week intervals. Rats were sacrificed at 48 h and 1, 2, 4, and 8 weeks after the tenth injection. Histomorphologically, knee joint samples were examined for osteoarthritic changes and stomach tissue samples for gastric changes.Results: Unlike methylprednisolone, diclofenac and tenoxicam caused increased fibrosis and fibroblast production; furthermore, chronic methylprednisolone use had no negative effects on the synovium or cartilage.Conclusion: Chronic tenoxicam and diclofenac use affects joints more negatively than chronic steroid treatment
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik
0
0
0
  • Brandt KD. Diagnosis and nonsurgical management of os- teoarthritis. First Edition. Caddo, OK: Professional Com- munications, Inc. 1996. [ISBN: 1-884735-09-6]
  • Cook TM, Tuckey JP, Nolan JP. Analgesia after day-case knee arthroscopy: double-blind study of intra-articular tenoxicam, intra-articular bupivacaine and placebo. Br J Anaesth 1997;78:163-8.
  • Colbert ST, Curran E, O'Hanlon DM, Moran R, Mc- Carroll M. Intra-articular tenoxicam improves post- operative analgesia in knee arthroscopy. Can J Anaesth 1999;46:653-7.
  • Uthman I, Raynauld JP, Haraoui B. Intra-articular therapy in osteoarthritis. Postgrad Med J 2003;79:449-53.
  • Ozyuvaci H, Bilgic B, Ozyuvaci E, Altan A, Altug T, Ka- raca C. Intra-articular injection of tenoxicam in rats: as- sessment of the local effects on the articular cartilage and synovium. J Int Med Res 2004;32:312-6.
  • Peckett WR, Butler-Manuel A. Intra-articular steroids af- ter arthroscopy for osteoarthritis of the knee. J Bone Joint Surg Br 2000;82:775-6.
  • Brandt KD. Management of osteoartritis. In Ruddy S, Ha- ris ED Jr, Sledge CB, editors. Kelley's Texbook of Rheu- matology. 6th ed. Philadelphia: W.B. Saunders Company 2001. pp. 1419-32.
  • Recommendations for the medical management of osteo- arthritis of the hip and knee: 2000 update. American Col- lege of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum 2000;43:1905-15.
  • Riggin CN, Tucker JJ, Soslowsky LJ, Kuntz AF. Intra-ar- ticular tibiofemoral injection of a nonsteroidal anti-inflam- matory drug has no detrimental effects on joint mechanics in a rat model. J Orthop Res 2014;32:1512-9.
  • Blot L, Marcelis A, Devogelaer JP, Manicourt DH. Effects of diclofenac, aceclofenac and meloxicam on the metabo- lism of proteoglycans and hyaluronan in osteoarthritic hu- man cartilage. Br J Pharmacol 2000;131:1413-21.
  • Ding C. Do NSAIDs affect the progression of osteoarthri- tis? Inflammation 2002;26:139-42.
  • Notoya K, Jovanovic DV, Reboul P, Martel-Pelletier J, Mineau F, Pelletier JP. The induction of cell death in hu- man osteoarthritis chondrocytes by nitric oxide is related to the production of prostaglandin E2 via the induction of cyclooxygenase-2. J Immunol 2000;165:3402-10.
  • Henroitin Y, Reginster JY. In-vitro differences among non- steroidal antiinflammatory drugs in their activities related to osteoarthritis pathophysiology. Osteoarthritis Cartilage 1999;7:355-7.
  • Mukherjee P, Rachita C, Aisen PS, Pasinetti GM. Non- steroidal anti-inflammatory drugs protect against chon- drocyte apoptotic death. Clin Exp Rheumatol 2001;19(1 Suppl 22):7-11.
  • Guler G, Karaoglu S, Velibasoglu H, Ramazanogullari N, Boyaci A. Comparison of analgesic effects of intra-articu- lar tenoxicam and morphine in anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 2002;10:229-32.
  • Oztuna V, Eskandari M, Bugdayci R, Kuyurtar F. Intra-ar- ticular injection of tenoxicam in osteoarthritic knee joints with effusion. Orthopedics 2007;30:1039-42.
  • Kirdemir P, Marsan A, Gogus N, Tabak Y, Tekin M. Com- parison between the analgesic effects of intraarticular neo- stigmine, tramadol and tenoxicam. Acta Orthop Trauma- tol Turc 2001;35:358-62.
  • Elhakim M, Nafie M, Eid A, Hassin M. Combination of intra-articular tenoxicam, lidocaine, and pethidine for outpatient knee arthroscopy. Acta Anaesthesiol Scand 1999;43:803-8.
  • Saricaoglu F, Dal D, Atilla P, Iskit AB, Tarhan O, Aşan E, et al. Effect of intraarticular injection of lornoxicam on the articular cartilage & synovium in rat. Indian J Med Res 2008;127:362-5.
  • Lane NE, Thompson JM. Management of osteoarthritis in the primary-care setting: an evidence-based approach to treatment. Am J Med 1997;103:25-30.
  • Godwin M, Dawes M. Intra-articular steroid injections for painful knees. Systematic review with meta-analysis. Can Fam Physician 2004;50:241-8.
  • Pelletier JP, Martel-Pelletier J. Recent developments in the therapy of osteoarthritis. In: Tsokos GC, editor. Modern Therapeutics in Rheumatic Diseases. Totowa, NJ: Huma- na Press; 2002. pp. 253-5.
  • Pasquali Ronchetti I, Guerra D, Taparelli F, Boraldi F, Bergamini G, Mori G, et al. Morphological analysis of knee synovial membrane biopsies from a randomized controlled clinical study comparing the effects of sodium hyaluronate (Hyalgan) and methylprednisolone acetate (Depomedrol) in osteoarthritis. Rheumatology (Oxford) 2001;40:158-69.
  • Gosal HS, Jackson AM, Bickerstaff DR. Intra-articular steroids after arthroscopy for osteoarthritis of the knee. J Bone Joint Surg Br 1999;81:952-4.
  • Ratiner B, Gramas DA, Lane NE. Osteoarthritis. In: Weisman MH, Weinblatt ME, Louis JS, editors. Treat- ment of the Rheumatic Diseases. Companion to Kelley's Textbook of Rheumatology. 2nd ed. Philadelphia: W.B. Saunders Company; 2001. pp. 461-86.
  • Ayral X. Injections in the treatment of osteoarthritis. Best Pract Res Clin Rheumatol 2001;15:609-26.
  • Creamer P. Intra-articular corticosteroid injections in os- teoarthritis: do they work and if so, how? Ann Rheum Dis 1997;56:634-6.
  • Gossec L, Dougados M. Intra-articular treatments in os- teoarthritis: from the symptomatic to the structure modi- fying. Ann Rheum Dis 2004;63:478-82.
  • Gossec L, Dougados M. Do intra-articular therapies work and who will benefit most? Best Pract Res Clin Rheumatol 2006;20:131-44.
  • Kirwan J. Is there a place for intra-articular hyaluronate in osteoarthritis of the knee? Knee 2001;8:93-101.
  • Kirwan JR, Rankin E. Intra-articular therapy in osteoar- thritis. Baillieres Clin Rheumatol 1997;11:769-94.
  • Schumacher HR, Chen LX. Injectable corticoste
  • roids in treatment of arthritis of the knee. Am J Med 2005;118:1208-14.
  • Raynauld JP, Buckland-Wright C, Ward R, Choquette D, Haraoui B, Martel-Pelletier J, et al. Safety and efficacy of long-term intraarticular steroid injections in osteoarthri- tis of the knee: a randomized, double-blind, placebo-con- trolled trial. Arthritis Rheum 2003;48:370-7.
  • Jaffré B, Watrin A, Loeuille D, Gillet P, Netter P, Laugier P, et al. Effects of antiinflammatory drugs on arthritic car- tilage: a high-frequency quantitative ultrasound study in rats. Arthritis Rheum 2003;48:1594-601.
APA MÜFİT ORAK M, AK D, Midi A, LAÇİN B, PURİSA S, BULUT G (2015). Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats. , 438 - 446.
Chicago MÜFİT ORAK Mehmet,AK DURSUN,Midi Ahmet,LAÇİN BERNA,PURİSA Sevim,BULUT GÜVEN Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats. (2015): 438 - 446.
MLA MÜFİT ORAK Mehmet,AK DURSUN,Midi Ahmet,LAÇİN BERNA,PURİSA Sevim,BULUT GÜVEN Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats. , 2015, ss.438 - 446.
AMA MÜFİT ORAK M,AK D,Midi A,LAÇİN B,PURİSA S,BULUT G Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats. . 2015; 438 - 446.
Vancouver MÜFİT ORAK M,AK D,Midi A,LAÇİN B,PURİSA S,BULUT G Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats. . 2015; 438 - 446.
IEEE MÜFİT ORAK M,AK D,Midi A,LAÇİN B,PURİSA S,BULUT G "Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats." , ss.438 - 446, 2015.
ISNAD MÜFİT ORAK, Mehmet vd. "Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats". (2015), 438-446.
APA MÜFİT ORAK M, AK D, Midi A, LAÇİN B, PURİSA S, BULUT G (2015). Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats. Acta Orthopaedica et Traumatologica Turcica, 49(4), 438 - 446.
Chicago MÜFİT ORAK Mehmet,AK DURSUN,Midi Ahmet,LAÇİN BERNA,PURİSA Sevim,BULUT GÜVEN Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats. Acta Orthopaedica et Traumatologica Turcica 49, no.4 (2015): 438 - 446.
MLA MÜFİT ORAK Mehmet,AK DURSUN,Midi Ahmet,LAÇİN BERNA,PURİSA Sevim,BULUT GÜVEN Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats. Acta Orthopaedica et Traumatologica Turcica, vol.49, no.4, 2015, ss.438 - 446.
AMA MÜFİT ORAK M,AK D,Midi A,LAÇİN B,PURİSA S,BULUT G Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats. Acta Orthopaedica et Traumatologica Turcica. 2015; 49(4): 438 - 446.
Vancouver MÜFİT ORAK M,AK D,Midi A,LAÇİN B,PURİSA S,BULUT G Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats. Acta Orthopaedica et Traumatologica Turcica. 2015; 49(4): 438 - 446.
IEEE MÜFİT ORAK M,AK D,Midi A,LAÇİN B,PURİSA S,BULUT G "Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats." Acta Orthopaedica et Traumatologica Turcica, 49, ss.438 - 446, 2015.
ISNAD MÜFİT ORAK, Mehmet vd. "Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats". Acta Orthopaedica et Traumatologica Turcica 49/4 (2015), 438-446.
Sayfa Oluşturulma Tarihi
06-06-2024 7:50

İLETİŞİM

TÜBİTAK ULAKBİM TR Dizin

Yüzüncüyıl, İşçi Blokları Mahallesi

Muhsin Yazıcıoğlu Caddesi No:51/C

06530 Çankaya / ANKARA +90 (312) 298 92 00

trdizin@tubitak.gov.tr

TÜBİTAK ULAKBİM Ulusal Akademik Ağ ve Bilgi Merkezi Cahit Arf Bilgi Merkezi © Tüm Hakları Saklıdır. Gizlilik Politikası Kullanım Şartları