The Effect of Prenatal Invasive Tests on Neonatal Birthweight

Aydın, Emine; Goksuluk, Dincer; BEKSAÇ, M. Sinan; ÇAKAR, Ayşe Nur; TANAÇAN, Atakan; ÇAĞAN, Murat

The Effect of Prenatal Invasive Tests on Neonatal Birthweight

Atakan TANAÇAN, (Hacettepe Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Ankara, Türkiye)

Emine AYDIN, (TOBB Ekonomi ve Teknoloji Üniversitesi, Tıp Fakültesi, Ankara, Türkiye)

Ayşe Nur ÇAKAR, (TOBB Ekonomi ve Teknoloji Üniversitesi, Tıp Fakültesi, Ankara, Türkiye)

Murat ÇAĞAN, (Hacettepe Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Ankara, Türkiye)

DİNÇER GÖKSÜLÜK, (Hacettepe Üniversitesi, Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Ankara, Türkiye)

M. Sinan BEKSAÇ (Hacettepe Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Ankara, Türkiye)

GORM:Gynecology Obstetrics & Reproductive Medicine

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Yıl: 2015 Cilt: 21 Sayı: 3 Sayfa Aralığı: 127 - 129 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The Effect of Prenatal Invasive Tests on Neonatal Birthweight

Öz:

AMAÇ: Bu çalışmanın amacı, yenidoğan doğum ağırlığınaprenatal invazif prosedürlerin etkisini araştırmaktır.GEREÇ VE YÖNTEM: Bu çalışma üç gebelik grubundan oluşmaktadır; 1) Amniyosentez grubu (n=97), 2) koryon villus örneklemesi grubu (n=36), 3) Kontrol grubu (herhangi bir intrauterin müdahalesi olmayan hastalar, n=100). Bu çalışmada"Hacettepe Üniversitesi Perinatoloji Veri Tabanı" kullanılmıştır(Ocak 2013-Ocak 2014). Maternal komplikasyonu olmayan(doğum ağırlığını etkileyebilecek) tekiz gebelikler çalışmayadahil edilmiştir. Dışlama kriterleri: perinatal komplikasyon, konjenital anomalili fetüs, sitogenetik sorunları ve gen bozuklukluğu varlığını içermekteydi. Prenatal tanı onam formları, intrauterin müdahaleler öncesinde hastalar tarafından imzalandı.BULGULAR: Hasta grupları anne yaşı, gebelik haftası ve doğum ağırlığı açısından karşılaştırıldı. "Kontrol" ve "koryon villusörneklemesi" grubu bebeklerinin istatistiksel olarak "amniyosentez" grubu bebeklere göre ağır olduğu gösterildi (p=0,01).Ortalama (±SD) doğum ağırlığı değerleri "amniyosentez", "koryon villus örneklemesi" ve "kontrol" grubu için sırayla 3009±428 gr, 3178±409 gr ve 3283±358 gr idi. "Koryon villus örneklemesi" grubundaki ağırlık azalması anlamlı değildi (p=0,74). SONUÇ: Bu çalışmada, amniyosentezin muhtemelen doğumağırlığı değerlerini etkilediği gösterilmiştir. Azalan doğum ağırlığı, amniyosentezin kendisinin etkisi ile deprese olan veya artan çeşitli sitokinler, büyüme faktörleri ya da amniyosentezeneden olan altta yatan obstetrik nedenler olabilir

Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel

Prenatal İnvazif Testlerin Yenidoğan Doğum Ağırlığı Üzerine Etkisi

Öz:

OBJECTIVE: The aim of this study is to investigate the effect of prenatal invasive procedures on neonatal birth weight. STUDY DESIGN: The present study consists of three group of pregnancies; 1) Amniocentesis group(n=97), 2) Chorionic Villus Sampling group (n=36), 3) Control group (matched patients without any intrauterine intervention, n=100). "Hacettepe University Perinatology Datae Base" is used in this study(January 2013-January 2014 interval is used for the extraction of datae). Singleton pregnancies withoutmaternal complications (which may affect fetal birthweight) were included to this study. Exclusion criteria also includes cases with perinatal complications and fetuses with congenital abnormalities, cytogenetical problems and gene disorders. Consent forms were signed by patients prior to prenatal diagnosis and intrauterine interventions. RESULTS: Matched patient groups were compared in terms of maternal age, gestational week andneonatal birth weight. We have demonstrated that "control" group and "chorionic villus sampling" groupbabies are statistically significantly heavier than "amniocentesis" group babies (p=0.01). The mean(±SD) birthweight values are 3009 ±428 gr, 3178±409 gr and 3283±358 gr for the "amniocentesis" group,"chorionic villus sampling" group and "control" group respectively. Decreased birthweight values in"chorionic villus sampling" group is not statistically significant. (p=0.74 ). CONCLUSION: In this study, we have demonstrated that amniocentesis possibly influences the birthweight values. Decreased birthweight values may be due to the direct affect of amniocentesis itselfthrough the depression and/or activation of various cytokines or growth factors, or the result of obstetrical problems behind the amniocentesis indications

Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	TANAÇAN A, Aydın E, ÇAKAR A, ÇAĞAN M, Goksuluk D, BEKSAÇ M (2015). The Effect of Prenatal Invasive Tests on Neonatal Birthweight. , 127 - 129.
Chicago	TANAÇAN Atakan,Aydın Emine,ÇAKAR Ayşe Nur,ÇAĞAN Murat,Goksuluk Dincer,BEKSAÇ M. Sinan The Effect of Prenatal Invasive Tests on Neonatal Birthweight. (2015): 127 - 129.
MLA	TANAÇAN Atakan,Aydın Emine,ÇAKAR Ayşe Nur,ÇAĞAN Murat,Goksuluk Dincer,BEKSAÇ M. Sinan The Effect of Prenatal Invasive Tests on Neonatal Birthweight. , 2015, ss.127 - 129.
AMA	TANAÇAN A,Aydın E,ÇAKAR A,ÇAĞAN M,Goksuluk D,BEKSAÇ M The Effect of Prenatal Invasive Tests on Neonatal Birthweight. . 2015; 127 - 129.
Vancouver	TANAÇAN A,Aydın E,ÇAKAR A,ÇAĞAN M,Goksuluk D,BEKSAÇ M The Effect of Prenatal Invasive Tests on Neonatal Birthweight. . 2015; 127 - 129.
IEEE	TANAÇAN A,Aydın E,ÇAKAR A,ÇAĞAN M,Goksuluk D,BEKSAÇ M "The Effect of Prenatal Invasive Tests on Neonatal Birthweight." , ss.127 - 129, 2015.
ISNAD	TANAÇAN, Atakan vd. "The Effect of Prenatal Invasive Tests on Neonatal Birthweight". (2015), 127-129.

APA	TANAÇAN A, Aydın E, ÇAKAR A, ÇAĞAN M, Goksuluk D, BEKSAÇ M (2015). The Effect of Prenatal Invasive Tests on Neonatal Birthweight. GORM:Gynecology Obstetrics & Reproductive Medicine, 21(3), 127 - 129.
Chicago	TANAÇAN Atakan,Aydın Emine,ÇAKAR Ayşe Nur,ÇAĞAN Murat,Goksuluk Dincer,BEKSAÇ M. Sinan The Effect of Prenatal Invasive Tests on Neonatal Birthweight. GORM:Gynecology Obstetrics & Reproductive Medicine 21, no.3 (2015): 127 - 129.
MLA	TANAÇAN Atakan,Aydın Emine,ÇAKAR Ayşe Nur,ÇAĞAN Murat,Goksuluk Dincer,BEKSAÇ M. Sinan The Effect of Prenatal Invasive Tests on Neonatal Birthweight. GORM:Gynecology Obstetrics & Reproductive Medicine, vol.21, no.3, 2015, ss.127 - 129.
AMA	TANAÇAN A,Aydın E,ÇAKAR A,ÇAĞAN M,Goksuluk D,BEKSAÇ M The Effect of Prenatal Invasive Tests on Neonatal Birthweight. GORM:Gynecology Obstetrics & Reproductive Medicine. 2015; 21(3): 127 - 129.
Vancouver	TANAÇAN A,Aydın E,ÇAKAR A,ÇAĞAN M,Goksuluk D,BEKSAÇ M The Effect of Prenatal Invasive Tests on Neonatal Birthweight. GORM:Gynecology Obstetrics & Reproductive Medicine. 2015; 21(3): 127 - 129.
IEEE	TANAÇAN A,Aydın E,ÇAKAR A,ÇAĞAN M,Goksuluk D,BEKSAÇ M "The Effect of Prenatal Invasive Tests on Neonatal Birthweight." GORM:Gynecology Obstetrics & Reproductive Medicine, 21, ss.127 - 129, 2015.
ISNAD	TANAÇAN, Atakan vd. "The Effect of Prenatal Invasive Tests on Neonatal Birthweight". GORM:Gynecology Obstetrics & Reproductive Medicine 21/3 (2015), 127-129.