In this study, between 1995-2000, the distribution of malaria cases in Şanlıurfa was determined according to variables including (he year, month, place of residence, slide positive ratio, surveillance method, gender and age. According to the records, a total of 24,182 cases occurred during the six years. The agent of all these cases was found to be Plasmodium vivax. Although most of cases were reported as imported cases between 1995-1997, a great majority of cases were reported as indigenous cases between 1998-2000. Ninety-two percent of the cases were detected using the passive surveillance method. While the slide positive ratio was 5.3% in 1995, it decreased to about 3.4% in 1996-97, but in 1998 it increased to 5.9%. Since 1998, there has been a year by year decrease, with the slide positive ratio being 2.2% in 1999 and 0.4% in 2000. As to the monthly distribution of malaria cases, the number of cases increased between April and October, but the highest level occurred during the period from June to October. Most of cases were encountered in Siverek and Viranşehir. According to the records, 52.7% of the patients were males and 47.3%, females. No significant difference was found in the distribution of the genders. Between the years from 1995-2000, out of all the cases, 1% were infants aged 0-11 months.