An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome
Yıl: 2013 Cilt: 28 Sayı: 4 Sayfa Aralığı: 251 - 255 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome
Öz: Amaç: Bu çalışmada fibromiyalji sendromlu (FMS) hastalarda ortalama trombosit hacmi (OTH) ve serum lipid profili değerlendirildi.Hastalar ve yöntemler: Bu retrospektif çalışma, Ocak 2011 - Aralık 2011 tarihleri arasında üç merkeze başvuran 156 FMS hastası ve 118 sağlıklı kontrolden oluşuyordu. Hastaların açlık kan glukoz, total kolesterol, düşük yoğunluklu lipoprotein (LDL) ve yüksek yoğunluklu lipoprotein (HDL) kolesterol, trigliserid düzeyleri ve tam kan sayımı ve OTH değerleri kaydedildi. İstatistiksel analiz için verilerin dağılım yapısına göre Mann-Whitney U testi ve Student t-test kullanıldı.Bulgular: Çalışmanın etki büyüklüğü 0.6 iken deneysel gücü, %100 (0.00063) olarak hesaplandı. Ortalama trombosit hacmi, hasta grubunda 8.75±1.15 fL; sağlıklı kontrollerde 8.13±0.73 idi (p<0.001). Trigliserid düzeyleri, sağlıklı kontrollere kıyasla, FMS hastalarında anlamlı düzeyde artmıştı (p=0.003).Sonuç: Fibromiyalji sendromlu hastalarda aterosklerozun erken belirteçlerinden biri olan OTH'nin anlamlı düzeyde yüksek olduğu belirlendi.
Anahtar Kelime: Konular:
Fibromiyalji Sendromlu Hastalarda Ortalama Trombosit Hacminin ve Lipid Parametrelerinin Değerlendirilmesi
Öz: Objectives: This study aims to evaluate the mean platelet volume (MPV) and serum lipid profile in patients with fibromyalgia syndrome (FMS). Patients and methods: This retrospective study was comprised of 156 patients with FMS and 118 healthy controls who were admitted to three centers between January 2011 and December 2011. The patients' fasting blood glucose, total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, triglyceride levels and complete blood count, and MPV values were recorded. The Mann-Whitney U test and Student's t-test were used according to the distribution of the data for statistical analysis. Results: The experimental power of the study was found to be 100% (0.00063), when the effect size was taken as 0.6. The MPV value was 8.75±1.15 fL in the patient group and 8.13±0.73 in the healthy controls (p<0.001). The serum triglyceride levels were significantly increased in the patients with FMS compared with the healthy controls (p=0.003). Conclusion: We found that the MPV, one of the early markers of atherosclerosis, was significantly high in the FMS patients.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Forseth KO, Gran JT, Husby G. A population study of the incidence of fibromyalgia among women aged 26-55 yr. Br J Rheumatol 1997;36:1318-23.
- Wolfe F, Ross K, Anderson J, Russell IJ, Hebert L. The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum 1995;38:19-28.
- Güleç H, Sayar K, Yazici Güleç M. The relationship between psychological factors and health care-seeking behavior in fibromyalgia patients. [Article in Turkish] Turk Psikiyatri Derg 2007;18:22-30.
- Altındağ Ö. Fibromiyaljide nöroendokrin işlev bozuklukları. Turk J Rheumatol 2009;24:98-102.
- Russell AS, Gervais R. Cognitive function in fibromyalgia: comment on the article by Park et al. Arthritis Rheum 2002;46:1980.
- Cho KI, Lee JH, Lee HG, Kim SM, Kim TI. Assessment of myocardial function in patients with fibromyalgia and the relationship to chronic emotional and physical stress. Korean Circ J 2010;40:74-80.
- McCarberg B, Barkin RL, Wright JA, Cronan TA, Groessl E, Schmidt SM. Tender points as predictors of distress and the pharmacologic management of fibromyalgia syndrome. Am J Ther 2003;10:176-92.
- Giske L, Vİllestad NK, Mengshoel AM, Jensen J, Knardahl S, Rİe C. Attenuated adrenergic responses to exercise in women with fibromyalgia--a controlled study. Eur J Pain 2008;12:351-60.
- Martinez-Lavin M. Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia. Arthritis Res Ther 2007;9:216.
- McEwen BS. Protective and damaging effects of stress mediators: central role of the brain. Dialogues Clin Neurosci 2006;8:367-81.
- Tofler GH, Muller JE. Triggering of acute cardiovascular disease and potential preventive strategies. Circulation 2006;114:1863-72.
- Ünübol M, Ayhan M, Güney E. The relationship between mean platelet volume with microalbuminuria and glycemic control in patients with type II diabetes mellitus. Platelets 2012;23:475-80.
- Butterworth RJ, Bath PM. The relationship between mean platelet volume, stroke subtype and clinical outcome. Platelets 1998;9:359-64.
- Trowbridge EA, Martin JF. The platelet volume distribution: a signature of the prethrombotic state in coronary heart disease? Thromb Haemost 1987; 58:714-7.
- Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 1990;33:160-72.
- Lee JH, Cho KI, Kim SM, Lee HG, Kim TI. Arterial stiffness in female patients with fibromyalgia and its relationship to chronic emotional and physical stress. Korean Circ J 2011;41:596-602.
- Cho KI, Lee JH, Kim SM, Lee HG, Kim TI. Assessment of endothelial function in patients with fibromyalgia--cardiac ultrasound study. Clin Rheumatol 2011;30:647-54.
- Ablin JN, Beilinson N, Aloush V, Elkayam O, Finkelstein A. Association between fibromyalgia and coronary heart disease and coronary catheterization. Clin Cardiol 2009;32:E7-11.
- Haviland MG, Banta JE, Przekop P. Fibromyalgia: prevalence, course, and co-morbidities in hospitalized patients in the United States, 1999-2007. Clin Exp Rheumatol 2011;29:S79-87.
- Coban E, Kucuktag S, Basyigit S. Platelet activation in subjects with impaired glucose tolerance. Platelets 2007;18:591-4.
- Martin JF, Bath PM, Burr ML. Influence of platelet size on outcome after myocardial infarction. Lancet 1991;338:1409-11.
- Bath PM, Missouris CG, Buckenham T, MacGregor GA. Increased platelet volume and platelet mass in patients with atherosclerotic renal artery stenosis. Clin Sci (Lond) 1994;87:253-7.
- Han JY, Choi DH, Choi SW, Kim BB, Ki YJ, Chung JW, et al. Stroke or coronary artery disease prediction from mean platelet volume in patients with type 2 diabetes mellitus. Platelets 2013;24:401-6.
- Greisenegger S, Endler G, Hsieh K, Tentschert S, Mannhalter C, Lalouschek W. Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events? Stroke 2004;35:1688-91.
- Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: is there a practical index of platelet activity? Clin Appl Thromb Hemost 2003;9:177-90.
- Endler G, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C, et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 2002;117:399-404.
- Bitigen A, Tanalp AC, Elonu OH, Karavelioglu Y, Ozdemir N. Mean platelet volume in patients with isolated coronary artery ectasia. J Thromb Thrombolysis 2007;24:99-103.
- Celik T, Yuksel UC, Bugan B, Iyisoy A, Celik M, Demirkol S, et al. Increased platelet activation in patients with slow coronary flow. J Thromb Thrombolysis 2010;29:310-5.
- Gurer G, Sendur OF, Ay C. Serum lipid profile in fibromyalgia women. Clin Rheumatol 2006;25:300-3.
- Ozgocmen S, Ardicoglu O. Lipid profile in patients with fibromyalgia and myofascial pain syndromes. Yonsei Med J 2000;41:541-5.
- Okifuji A, Bradshaw DH, Olson C. Evaluating obesity in fibromyalgia: neuroendocrine biomarkers, symptoms, and functions. Clin Rheumatol 2009;28:475-8.
- Bardal E, Olsen T, Ettema G, Mork P. Metabolic rate, cardiac response, and aerobic capacity in fibromyalgia: a case-control study. Scand J Rheumatol 2013. [Epub ahead of print]
| APA | İYİYAPICI UNUBOL A, TAŞÇI BOZBAŞ G, ünübol m, gurer g (2013). An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome. , 251 - 255. |
| Chicago | İYİYAPICI UNUBOL Ayşe,TAŞÇI BOZBAŞ GÜLNUR,ünübol mustafa,gurer gülcan An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome. (2013): 251 - 255. |
| MLA | İYİYAPICI UNUBOL Ayşe,TAŞÇI BOZBAŞ GÜLNUR,ünübol mustafa,gurer gülcan An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome. , 2013, ss.251 - 255. |
| AMA | İYİYAPICI UNUBOL A,TAŞÇI BOZBAŞ G,ünübol m,gurer g An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome. . 2013; 251 - 255. |
| Vancouver | İYİYAPICI UNUBOL A,TAŞÇI BOZBAŞ G,ünübol m,gurer g An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome. . 2013; 251 - 255. |
| IEEE | İYİYAPICI UNUBOL A,TAŞÇI BOZBAŞ G,ünübol m,gurer g "An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome." , ss.251 - 255, 2013. |
| ISNAD | İYİYAPICI UNUBOL, Ayşe vd. "An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome". (2013), 251-255. |
| APA | İYİYAPICI UNUBOL A, TAŞÇI BOZBAŞ G, ünübol m, gurer g (2013). An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome. Turkish Journal of Rheumatology(.)Archives of Rheumatology, 28(4), 251 - 255. |
| Chicago | İYİYAPICI UNUBOL Ayşe,TAŞÇI BOZBAŞ GÜLNUR,ünübol mustafa,gurer gülcan An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome. Turkish Journal of Rheumatology(.)Archives of Rheumatology 28, no.4 (2013): 251 - 255. |
| MLA | İYİYAPICI UNUBOL Ayşe,TAŞÇI BOZBAŞ GÜLNUR,ünübol mustafa,gurer gülcan An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome. Turkish Journal of Rheumatology(.)Archives of Rheumatology, vol.28, no.4, 2013, ss.251 - 255. |
| AMA | İYİYAPICI UNUBOL A,TAŞÇI BOZBAŞ G,ünübol m,gurer g An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome. Turkish Journal of Rheumatology(.)Archives of Rheumatology. 2013; 28(4): 251 - 255. |
| Vancouver | İYİYAPICI UNUBOL A,TAŞÇI BOZBAŞ G,ünübol m,gurer g An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome. Turkish Journal of Rheumatology(.)Archives of Rheumatology. 2013; 28(4): 251 - 255. |
| IEEE | İYİYAPICI UNUBOL A,TAŞÇI BOZBAŞ G,ünübol m,gurer g "An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome." Turkish Journal of Rheumatology(.)Archives of Rheumatology, 28, ss.251 - 255, 2013. |
| ISNAD | İYİYAPICI UNUBOL, Ayşe vd. "An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome". Turkish Journal of Rheumatology(.)Archives of Rheumatology 28/4 (2013), 251-255. |
