The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism

DEMİRCİ, Serpil; OLGAÇ DÜNDAR, NİHAL; PİRGON, Mustafa Özgür; KOCA, Tugba; DÜNDAR, Bumin Nuri; Sangun, Ozlem; DOĞAN, Melike

The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism

Özlem SANGÜN, (Başkent Üniversitesi, Tıp Fakültesi, Çocuk Endokrinoloji Bölümü, Adana, Türkiye)

Serpil DEMİRCİ, (Süleyman Demirel Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Isparta, Türkiye)

NİHAL OLGAÇ DÜNDAR, (İzmir Katip Çelebi Üniveristesi, Tıp Fakültesi, Çocuk Nöroloji, Ana Bilim Dalı, İzmir, Türkiye)

Mustafa Özgür PİRGON, (Süleyman Demirel Üniversitesi, Tıp Fakültesi, Çocuk Endokrinolojisi Anabilim Dalı, Isparta, Türkiye)

TUĞBA GÜRSOY KOCA, (Süleyman Demirel Üniversitesi, Tıp Fakültesi, Çocuk Endokrinolojisi Anabilim Dalı, Isparta, Türkiye)

Melike DOĞAN, (Süleyman Demirel Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Isparta, Türkiye)

Bumin Nuri DÜNDAR (İzmir Katip Çelebi Üniversitesi, Tıp Fakültesi,Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Endokrinoloji Bilim Dalı, İzmir, Türkiye)

Journal of Clinical Research in Pediatric Endocrinology

3 0

Yıl: 2015 Cilt: 7 Sayı: 2 Sayfa Aralığı: 102 - 108 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism

Öz:

Objective: The aim of this study was to investigate the cognitive status of children with subclinical hypothyroidism (SH) before and after L-thyroxine (L-T4) treatment using event-related potentials (ERPs) and neuropsychological tests.Methods: This prospective study was conducted on a series of 20 children with mild SH (free T4 normal and thyroid-stimulating hormone level within 5-10 µIU/L) who underwent clinical and cognitive assessment before L-T4 treatment and 6 months afterwards. The recordings of ERPs were done at the time of diagnosis and after 6 months of euthyroid state. Neuropsychiatric tests for attention, perception, close and remote memory were performed on all patients and on the control group which consisted of 20 healthy children of normal intelligence.Results: While pretreatment verbal memory (VM) and verbal recall (VR) scores of the SH group were significantly lower than those of the control group (p=0.004 and 0.012, respectively), no significant differences between the post-treatment and control groups were found in these scores after 6 months of L-T4 treatment. Post-treatment VM and VR scores were significantly higher than the pretreatment scores in the SH group (p=0.008 and p=0.0001). There were no significant differences between the pre-and post-treatment values of electrophysiological evaluation in N1, P2, P3 latencies or P3 amplitude (p>0.05), although there was a significant decrease in N2 latency in the posttreatment group (p=0.03).Conclusion: SH affects cognition in children and L-T4 replacement therapy leads to normalization of cognitive functions. Neuropsychological tests can be used as complementary measures in the evaluation of children with SH. Determining the association between ERPs and SH would contribute to the comprehensive evaluation of these children.

Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma Pediatri

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Sangun O, DEMİRCİ S, OLGAÇ DÜNDAR N, PİRGON M, KOCA T, DOĞAN M, DÜNDAR B (2015). The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism. , 102 - 108.
Chicago	Sangun Ozlem,DEMİRCİ Serpil,OLGAÇ DÜNDAR NİHAL,PİRGON Mustafa Özgür,KOCA Tugba,DOĞAN Melike,DÜNDAR Bumin Nuri The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism. (2015): 102 - 108.
MLA	Sangun Ozlem,DEMİRCİ Serpil,OLGAÇ DÜNDAR NİHAL,PİRGON Mustafa Özgür,KOCA Tugba,DOĞAN Melike,DÜNDAR Bumin Nuri The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism. , 2015, ss.102 - 108.
AMA	Sangun O,DEMİRCİ S,OLGAÇ DÜNDAR N,PİRGON M,KOCA T,DOĞAN M,DÜNDAR B The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism. . 2015; 102 - 108.
Vancouver	Sangun O,DEMİRCİ S,OLGAÇ DÜNDAR N,PİRGON M,KOCA T,DOĞAN M,DÜNDAR B The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism. . 2015; 102 - 108.
IEEE	Sangun O,DEMİRCİ S,OLGAÇ DÜNDAR N,PİRGON M,KOCA T,DOĞAN M,DÜNDAR B "The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism." , ss.102 - 108, 2015.
ISNAD	Sangun, Ozlem vd. "The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism". (2015), 102-108.

APA	Sangun O, DEMİRCİ S, OLGAÇ DÜNDAR N, PİRGON M, KOCA T, DOĞAN M, DÜNDAR B (2015). The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism. Journal of Clinical Research in Pediatric Endocrinology, 7(2), 102 - 108.
Chicago	Sangun Ozlem,DEMİRCİ Serpil,OLGAÇ DÜNDAR NİHAL,PİRGON Mustafa Özgür,KOCA Tugba,DOĞAN Melike,DÜNDAR Bumin Nuri The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism. Journal of Clinical Research in Pediatric Endocrinology 7, no.2 (2015): 102 - 108.
MLA	Sangun Ozlem,DEMİRCİ Serpil,OLGAÇ DÜNDAR NİHAL,PİRGON Mustafa Özgür,KOCA Tugba,DOĞAN Melike,DÜNDAR Bumin Nuri The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism. Journal of Clinical Research in Pediatric Endocrinology, vol.7, no.2, 2015, ss.102 - 108.
AMA	Sangun O,DEMİRCİ S,OLGAÇ DÜNDAR N,PİRGON M,KOCA T,DOĞAN M,DÜNDAR B The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism. Journal of Clinical Research in Pediatric Endocrinology. 2015; 7(2): 102 - 108.
Vancouver	Sangun O,DEMİRCİ S,OLGAÇ DÜNDAR N,PİRGON M,KOCA T,DOĞAN M,DÜNDAR B The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism. Journal of Clinical Research in Pediatric Endocrinology. 2015; 7(2): 102 - 108.
IEEE	Sangun O,DEMİRCİ S,OLGAÇ DÜNDAR N,PİRGON M,KOCA T,DOĞAN M,DÜNDAR B "The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism." Journal of Clinical Research in Pediatric Endocrinology, 7, ss.102 - 108, 2015.
ISNAD	Sangun, Ozlem vd. "The Effects of Six-Month L-Thyroxine Treatment on Cognitive Functions and Event-Related Brain Potentials in Children with Subclinical Hypothyroidism". Journal of Clinical Research in Pediatric Endocrinology 7/2 (2015), 102-108.