Secondary Neoplasms in Children with Hodgkin's Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases
Yıl: 2016 Cilt: 33 Sayı: 1 Sayfa Aralığı: 66 - 70 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
Secondary Neoplasms in Children with Hodgkin's Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases
Öz: Yaşayan Hodgkin lenfomalı olgularda ikincil neoplazilerin gelişme riski yüksektir. Lösemiler, Hodgkin-dışı malign lenfomalar ve solid tümörler özellikle meme ve tiroid kanserlerini içeren çok çeşitli ikincil malign neoplaziler raporlanmıştır. Burada kemoradyoterapi alan Hodgkin lenfomalı dört olguda gelişen ikincil neoplaziler sunulmuştur. İlginç olarak hastalarımızdan birinde ışın alanında üç ikincil neoplazm; fibrosarkom, tiroid karsinom ve retrobulber meningiom, diğer bir hastamızda sıradışı ikincil malign neoplazm olarak hipofaringeal epitelyal malign periferik sinir kılıfı tümörü gelişirken kız hastada farklı zamanlarda benign tiroid nodülü ve invaziv duktal meme kanseri saptandı. Bir hastamızda ise, tiroidde folliküler adenoma gelişti.
Anahtar Kelime: Konular:
C-MOPP ve Radyoterapi Alan Hodgkin Lenfomalı Çocuklarda İkincil Neoplaziler: Dört Olgu Sunumu
Öz: Patients who survive Hodgkin lymphoma (HL) are at increased risk of secondary neoplasms (SNs). A wide variety of SNs have been reported, including leukemias, non-Hodgkin's lymphomas, and solid tumors, specifically breast and thyroid cancers. Herein we report subsequent neoplasms in four patients with HL receiving chemoradiotherapy. It is interesting that three SNs, fibrosarcoma, thyroid carcinoma, and retrobulbar meningioma, were observed in the radiation area in one of our patients. A hypopharyngeal epithelioid malignant peripheral nerve sheath tumor as an unusual secondary malignant neoplasm developed in another patient, while a benign thyroid nodule and invasive ductal breast carcinoma were observed at different times in the female patient. Follicular adenoma of the thyroid gland developed in one of our patients.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
- National Cancer Institute. Late Effects of Treatment for Childhood Cancer (PDQ®). Second Cancers. Rockville, MD, USA, National Cancer Institute, Available online at http://www.cancer.gov/types/childhood-cancers/ late-effects-pdq#section/_36.
- Green DM. Long-Term Complications of Therapy for Cancer in Childhood and Adolescence. Baltimore, MD, USA, The Johns Hopkins University Press, 1989.
- Wolden SL, Lamborn KR, Cleary SF, Tate DJ, Donaldson SS. Second cancers following pediatric Hodgkin's disease. J Clin Oncol 1998;16:536-544.
- Bhatia S, Robison LL, Oberlin O, Greenberg M, Bunin G, Fossati-Bellani F, Meadows AT. Breast cancer and other second neoplasms after childhood Hodgkin's disease. N Engl J Med 1996;334:745-751.
- Meadows AT, Baum E, Fossati-Bellani F, Green D, Jenkin RD, Marsden B, Nesbit M, Newton W, Oberlin O, Sallan SG, Siegel S, Strong LC, Voute PA. Second malignant neoplasms in children: an update from the Late Effects Study Group. J Clin Oncol 1985;3:532-538.
- Swerdlow AJ, Barber JA, Hudson GV, Cunningham D, Gupta RK, Hancock BW, Horwich A, Lister TA, Linch DC. Risk of second malignancy after Hodgkin's disease in a collaborative British cohort: the relation to age at treatment. J Clin Oncol 2000;18:498-509.
- Boice JD Jr. Cancer following irradiation in childhood and adolescence. Med Pediatr Oncol Suppl 1996;1:29-34.
- O'Neil MB Jr, Cocke W, Mason D, Hurley EJ. Radiation induced soft-tissue fibrosarcoma: surgical therapy and salvage. Ann Thorac Surg 1982;33:624-628.
- Gözdasoglu S, Cavdar AO, Babacan E. Late effects (including 2nd malignancy) in Turkish children with Hodgkin's disease. In: SIOP XVIII Annual Meeting. Belgrade, Yugoslavia, Abstract Book, 1986:183-185.
- Gözdasoglu S, Cavdar AO, Babacan E, Mengübas K, Yavuz G, Unal E, Pamir A, Ocal G, Gökcora I. Late effects of chemoradiotherapy in pediatric Hodgkin's disease. J Chemother 1995;7:463-466.
- Acharya S, Sarafoglou K, LaQuaglia M, Lindsley S, Gerald W, Wollner N, Tan C, Sklar C. Thyroid neoplasms after therapeutic radiation for malignancies during childhood or adolescence. Cancer 2003;97:2997-2403.
- Best T, Li D, Skol AD, Kirchhoff T, Jackson SA, Yasui Y, Bhatia S, Strong LC, Domchek SM, Nathanson KL, Olopade OI, Huang RS, Mack TM, Conti DV, Offit K, Cozen W, Robison LL, Onel K. Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin lymphoma. Nat Med 2011;17:941-943.
- Gözdaşoğlu S, Ceyhan K, Üstüner E, Akyar S, Doğan M, İçli F. Hypopharyngeal epithelioid malignant schwannoma following treatment of Hodgkin's lymphoma. Int J Case Report Med 2015;2015:275309.
- Reis Filho JS, Pope LZ, Balderrama CM, Fillus-Neto J, Schmitt FC. Epithelioid malignant peripheral nerve sheath tumour: case report and review of the previously published cases. Cytopathology 2002;13:54-63.
- Adamson DC, Cummings TJ, Friedman AH. Malignant peripheral nerve sheath tumor of the spine after radiation therapy for Hodgkin's lymphoma. Clin Neuropathol 2004;23:245-255.
- Yeoh KW, Mikhaeel NG. Role of radiotherapy in modern treatment of Hodgkin's lymphoma. Adv Hematol 2011;2011:258797.
- Specht L, Yahalom J, Illidge T, Berthelsen AK, Constine LS, Eich HT, Girinsky T, Hoppe RT, Mauch P, Mikhaeel NG, Ng A; ILROG. Modern radiation therapy for Hodgkin lymphoma: field and dose guidelines from the international lymphoma radiation oncology group. Int J Radiat Oncol Biol Phys 2014;89:854-862.
| APA | Gozdasoglu Kucukalioglu E, PAMİR A, ÜNAL E, GÖKÇORA İ, ULUOĞLU Ö, CEYHAN K, DEDA H, IŞIKMAN E, YAVUZ G, TAÇYILDIZ N, ÇAVDAR A (2016). Secondary Neoplasms in Children with Hodgkin's Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases. , 66 - 70. |
| Chicago | Gozdasoglu Kucukalioglu Elif,PAMİR Ali,ÜNAL Emel,GÖKÇORA İsmail Haluk,ULUOĞLU Ömer,CEYHAN Koray,DEDA Haluk,IŞIKMAN Erdoğan,YAVUZ Gülsan,TAÇYILDIZ Nurdan,ÇAVDAR Ayhan Secondary Neoplasms in Children with Hodgkin's Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases. (2016): 66 - 70. |
| MLA | Gozdasoglu Kucukalioglu Elif,PAMİR Ali,ÜNAL Emel,GÖKÇORA İsmail Haluk,ULUOĞLU Ömer,CEYHAN Koray,DEDA Haluk,IŞIKMAN Erdoğan,YAVUZ Gülsan,TAÇYILDIZ Nurdan,ÇAVDAR Ayhan Secondary Neoplasms in Children with Hodgkin's Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases. , 2016, ss.66 - 70. |
| AMA | Gozdasoglu Kucukalioglu E,PAMİR A,ÜNAL E,GÖKÇORA İ,ULUOĞLU Ö,CEYHAN K,DEDA H,IŞIKMAN E,YAVUZ G,TAÇYILDIZ N,ÇAVDAR A Secondary Neoplasms in Children with Hodgkin's Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases. . 2016; 66 - 70. |
| Vancouver | Gozdasoglu Kucukalioglu E,PAMİR A,ÜNAL E,GÖKÇORA İ,ULUOĞLU Ö,CEYHAN K,DEDA H,IŞIKMAN E,YAVUZ G,TAÇYILDIZ N,ÇAVDAR A Secondary Neoplasms in Children with Hodgkin's Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases. . 2016; 66 - 70. |
| IEEE | Gozdasoglu Kucukalioglu E,PAMİR A,ÜNAL E,GÖKÇORA İ,ULUOĞLU Ö,CEYHAN K,DEDA H,IŞIKMAN E,YAVUZ G,TAÇYILDIZ N,ÇAVDAR A "Secondary Neoplasms in Children with Hodgkin's Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases." , ss.66 - 70, 2016. |
| ISNAD | Gozdasoglu Kucukalioglu, Elif vd. "Secondary Neoplasms in Children with Hodgkin's Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases". (2016), 66-70. |
| APA | Gozdasoglu Kucukalioglu E, PAMİR A, ÜNAL E, GÖKÇORA İ, ULUOĞLU Ö, CEYHAN K, DEDA H, IŞIKMAN E, YAVUZ G, TAÇYILDIZ N, ÇAVDAR A (2016). Secondary Neoplasms in Children with Hodgkin's Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases. Turkish Journal of Hematology, 33(1), 66 - 70. |
| Chicago | Gozdasoglu Kucukalioglu Elif,PAMİR Ali,ÜNAL Emel,GÖKÇORA İsmail Haluk,ULUOĞLU Ömer,CEYHAN Koray,DEDA Haluk,IŞIKMAN Erdoğan,YAVUZ Gülsan,TAÇYILDIZ Nurdan,ÇAVDAR Ayhan Secondary Neoplasms in Children with Hodgkin's Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases. Turkish Journal of Hematology 33, no.1 (2016): 66 - 70. |
| MLA | Gozdasoglu Kucukalioglu Elif,PAMİR Ali,ÜNAL Emel,GÖKÇORA İsmail Haluk,ULUOĞLU Ömer,CEYHAN Koray,DEDA Haluk,IŞIKMAN Erdoğan,YAVUZ Gülsan,TAÇYILDIZ Nurdan,ÇAVDAR Ayhan Secondary Neoplasms in Children with Hodgkin's Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases. Turkish Journal of Hematology, vol.33, no.1, 2016, ss.66 - 70. |
| AMA | Gozdasoglu Kucukalioglu E,PAMİR A,ÜNAL E,GÖKÇORA İ,ULUOĞLU Ö,CEYHAN K,DEDA H,IŞIKMAN E,YAVUZ G,TAÇYILDIZ N,ÇAVDAR A Secondary Neoplasms in Children with Hodgkin's Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases. Turkish Journal of Hematology. 2016; 33(1): 66 - 70. |
| Vancouver | Gozdasoglu Kucukalioglu E,PAMİR A,ÜNAL E,GÖKÇORA İ,ULUOĞLU Ö,CEYHAN K,DEDA H,IŞIKMAN E,YAVUZ G,TAÇYILDIZ N,ÇAVDAR A Secondary Neoplasms in Children with Hodgkin's Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases. Turkish Journal of Hematology. 2016; 33(1): 66 - 70. |
| IEEE | Gozdasoglu Kucukalioglu E,PAMİR A,ÜNAL E,GÖKÇORA İ,ULUOĞLU Ö,CEYHAN K,DEDA H,IŞIKMAN E,YAVUZ G,TAÇYILDIZ N,ÇAVDAR A "Secondary Neoplasms in Children with Hodgkin's Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases." Turkish Journal of Hematology, 33, ss.66 - 70, 2016. |
| ISNAD | Gozdasoglu Kucukalioglu, Elif vd. "Secondary Neoplasms in Children with Hodgkin's Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases". Turkish Journal of Hematology 33/1 (2016), 66-70. |
