Clues to the diagnosis of biliary atresia in neonatal cholestasis

Özden, Önder; Alkan, Murat; AĞIN, Mehmet; Tuncer, Recep; tumgor, gokhan; SATAR, Mehmet

Clues to the diagnosis of biliary atresia in neonatal cholestasis

Mehmet AĞIN, (Çukurova Üniversitesi, Tıp Fakültesi, Pediatrik Gastroenteroloji Bölümü, Adana, Türkiye)

Gökhan TÜMGÖR, (Çukurova Üniversitesi, Tıp Fakültesi, Pediatrik Gastroenteroloji Bölümü, Adana, Türkiye)

Murat ALKAN, (Çukurova Üniversitesi, Tıp Fakültesi, Çocuk Cerrahisi Anabilim Dalı, Adana, Türkiye)

Önder ÖZDEN, (Çukurova Üniversitesi, Tıp Fakültesi, Çocuk Cerrahisi Anabilim Dalı, Adana, Türkiye)

Mehmet SATAR, (Çukurova Üniversitesi, Tıp Fakültesi, Neonatoloji Anabilim Dalı, Adana, Türkiye)

Recep TUNCER (Çukurova Üniversitesi, Tıp Fakültesi, Çocuk Cerrahisi Anabilim Dalı, Adana, Türkiye)

Turkish Journal of Gastroenterology

1 1

Yıl: 2016 Cilt: 27 Sayı: 1 Sayfa Aralığı: 37 - 41 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Clues to the diagnosis of biliary atresia in neonatal cholestasis

Öz:

Background/Aims: The purpose of this study was to identify important clues in differentiating biliary atresia (BA) from causes of neonatal cholestasis other than BA (non-BA) and establishing the reliability of current tests.Materials and Methods: Thirty-four patients with BA and 27 patients with non-BA cholestasis being monitored at the Çukurova University Medical Faculty, the Pediatric Gastroenterology Department and the Pediatric Surgery Department between 2009 and 2015 were retrospectively assessed. Results: Cases of early onset jaundice, acholic stool, gamma-glutamyl transferase (GGT) elevation, and absent or small gallbladder on ultrasonography (USG) were greater in the BA group, while the levels of consanguinity and splenomegaly were higher in the non-BA group. The highest positive predictive value and specificity was determined for a GGT level greater than 197 in addition to absent or small gallbladder on USG and acholic stool in the BA group. Moreover, the presence of acholic stool (97%) exhibited the highest sensitivity and accuracy in the diagnosis of BA.Conclusion: Pale stool, GGT elevation, and absent or small gallbladder on USG are the most reliable tests for diagnosing BA. We recommend that intraoperative cholangiography should be performed without waiting for further test results when a neonate or infant presents with acholic stool, high GGT values, and absent or small gallbladder on abdominal USG

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	AĞIN M, tumgor g, Alkan M, Özden Ö, SATAR M, Tuncer R (2016). Clues to the diagnosis of biliary atresia in neonatal cholestasis. , 37 - 41.
Chicago	AĞIN Mehmet,tumgor gokhan,Alkan Murat,Özden Önder,SATAR Mehmet,Tuncer Recep Clues to the diagnosis of biliary atresia in neonatal cholestasis. (2016): 37 - 41.
MLA	AĞIN Mehmet,tumgor gokhan,Alkan Murat,Özden Önder,SATAR Mehmet,Tuncer Recep Clues to the diagnosis of biliary atresia in neonatal cholestasis. , 2016, ss.37 - 41.
AMA	AĞIN M,tumgor g,Alkan M,Özden Ö,SATAR M,Tuncer R Clues to the diagnosis of biliary atresia in neonatal cholestasis. . 2016; 37 - 41.
Vancouver	AĞIN M,tumgor g,Alkan M,Özden Ö,SATAR M,Tuncer R Clues to the diagnosis of biliary atresia in neonatal cholestasis. . 2016; 37 - 41.
IEEE	AĞIN M,tumgor g,Alkan M,Özden Ö,SATAR M,Tuncer R "Clues to the diagnosis of biliary atresia in neonatal cholestasis." , ss.37 - 41, 2016.
ISNAD	AĞIN, Mehmet vd. "Clues to the diagnosis of biliary atresia in neonatal cholestasis". (2016), 37-41.

APA	AĞIN M, tumgor g, Alkan M, Özden Ö, SATAR M, Tuncer R (2016). Clues to the diagnosis of biliary atresia in neonatal cholestasis. Turkish Journal of Gastroenterology, 27(1), 37 - 41.
Chicago	AĞIN Mehmet,tumgor gokhan,Alkan Murat,Özden Önder,SATAR Mehmet,Tuncer Recep Clues to the diagnosis of biliary atresia in neonatal cholestasis. Turkish Journal of Gastroenterology 27, no.1 (2016): 37 - 41.
MLA	AĞIN Mehmet,tumgor gokhan,Alkan Murat,Özden Önder,SATAR Mehmet,Tuncer Recep Clues to the diagnosis of biliary atresia in neonatal cholestasis. Turkish Journal of Gastroenterology, vol.27, no.1, 2016, ss.37 - 41.
AMA	AĞIN M,tumgor g,Alkan M,Özden Ö,SATAR M,Tuncer R Clues to the diagnosis of biliary atresia in neonatal cholestasis. Turkish Journal of Gastroenterology. 2016; 27(1): 37 - 41.
Vancouver	AĞIN M,tumgor g,Alkan M,Özden Ö,SATAR M,Tuncer R Clues to the diagnosis of biliary atresia in neonatal cholestasis. Turkish Journal of Gastroenterology. 2016; 27(1): 37 - 41.
IEEE	AĞIN M,tumgor g,Alkan M,Özden Ö,SATAR M,Tuncer R "Clues to the diagnosis of biliary atresia in neonatal cholestasis." Turkish Journal of Gastroenterology, 27, ss.37 - 41, 2016.
ISNAD	AĞIN, Mehmet vd. "Clues to the diagnosis of biliary atresia in neonatal cholestasis". Turkish Journal of Gastroenterology 27/1 (2016), 37-41.