Yıl: 2015 Cilt: 12 Sayı: 1 Sayfa Aralığı: 38 - 42 Metin Dili: Türkçe

Uterus transplantation: Experimental animal models and recent experience in humans

Öz:
Uterus transplantasyonu konjenital veya edinsel nedenlere bağlı uterusu olmayan kadınlarda evlat edinme ve taşıyıcı anneliğe bir alternatif yöntem olarak uygulanmaya başlanmıştır. Taşıyıcı annelik etik, sosyal ve hukuki nedenlerden dolayı sadece bazı ülkelerde yasaldır. Günümüze kadar insanda toplam 11 tane uterus transplantasyonu gerçekleştirilmiştir. Bunlardan 10'u canlı donörlerden biri ise beyin ölümü gerçekleşmiş bir donörden yapılmış nakillerdir. 2000 yılında başarısız olan ilk uterus transplantasyonu sonrası çeşitli hayvan modelleri üzerinde çalışmalar yapılmış bu da bu konuda bilgi birikimimizin artmasını sağlamıştır. İlk olarak kemirgenlerde başlayan çalışmalar sonrasında koyun, domuz ve tavşan modellerinde denenmiştir. Yakın zamanda, insan dışı primatlarda yapılan çalışmalar transplantasyon tekniği ile ilgili tecrübemizin artmasını sağlamıştır. Bu derlemede, uterus transplantasyonu ile ilgili yapılmış olan deneysel hayvan modelleri ve insanlardaki son deneyimlerden bahsedeceğiz. J Turk Soc Obstet Gynecol 2015;1:38-42
Anahtar Kelime:

Uterus transplantasyonu: Deneysel hayvan modelleri ve insanlardaki son deneyimler

Öz:
Uterus transplantation has been considered as an alternative management modality in the last few years for adoption or gestational surrogacy for women with absence of uterus due to congenital or acquired reasons. Surrogacy is legal in only a few countries because of ethical, social and legal issues. Up to date, a total of 11 uterus transplantation cases have been reported in which uteri were harvested from ten live donors and one donor with brain death. After unsuccessful attempt of first uterus transplantation, many studies have been conducted in animals and these experimental models enabled our knowledge to increase on this topic. First experimental studies were performed in rodents; later uterus transplantation was accomplished in sheep, pigs and rabbits. Recently, researches in non-human primates have led the experience regarding transplantation technique and success to improve. In this review, we reviewed the experimental animal researches in the area of uterus transplantation and recent experience in humans. J Turk Soc Obstet Gynecol 2015;1:38-42
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
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APA ŞAHİN S, SELÇUK S, EROĞLU M, KARATEKE A (2015). Uterus transplantation: Experimental animal models and recent experience in humans. Turkish Journal of Obstetrics and Gynecology, 12(1), 38 - 42.
Chicago ŞAHİN SADIK,SELÇUK Selçuk,EROĞLU Mustafa,KARATEKE Ateş Uterus transplantation: Experimental animal models and recent experience in humans. Turkish Journal of Obstetrics and Gynecology 12, no.1 (2015): 38 - 42.
MLA ŞAHİN SADIK,SELÇUK Selçuk,EROĞLU Mustafa,KARATEKE Ateş Uterus transplantation: Experimental animal models and recent experience in humans. Turkish Journal of Obstetrics and Gynecology, vol.12, no.1, 2015, ss.38 - 42.
AMA ŞAHİN S,SELÇUK S,EROĞLU M,KARATEKE A Uterus transplantation: Experimental animal models and recent experience in humans. Turkish Journal of Obstetrics and Gynecology. 2015; 12(1): 38 - 42.
Vancouver ŞAHİN S,SELÇUK S,EROĞLU M,KARATEKE A Uterus transplantation: Experimental animal models and recent experience in humans. Turkish Journal of Obstetrics and Gynecology. 2015; 12(1): 38 - 42.
IEEE ŞAHİN S,SELÇUK S,EROĞLU M,KARATEKE A "Uterus transplantation: Experimental animal models and recent experience in humans." Turkish Journal of Obstetrics and Gynecology, 12, ss.38 - 42, 2015.