Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions

MAMMADOV, Ceyhun; BOZBAY, Mehmet; Cincin, Altug; Sarı, İbrahim; ÖZŞENEL, Ekmel Burak; BAŞARAN, Yelda; ATAŞ, Halil; SÜNBÜL, MURAT

Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions

Murat SÜNBÜL, (Marmara Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Altuğ ÇİNÇİN, (Marmara Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Mehmet BOZBAY, (Marmara Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Ceyhun MAMMADOV, (Marmara Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Halil ATAŞ, (Marmara Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Ekmel Burak ÖZŞENEL, (Şişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi, İstanbul, Türkiye)

İbrahim SARI, (Marmara Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Yelda BAŞARAN (Marmara Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Türk Kardiyoloji Derneği Arşivi

3 1

Yıl: 2016 Cilt: 44 Sayı: 4 Sayfa Aralığı: 281 - 288 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions

Öz:

Amaç: Arter sertlik parametrelerinden nabız dalga hızı (NDH) ve artırma indeksi (AIx) artmış kardiyovasküler risk ile ilişkilidir. Önceki çalışmalarda vitamin D eksikliği ve kardiyovasküler hastalık arasında yakın bir ilişki olduğu gösterilmiştir. Çalışmamızın amacı normal kalp fonksiyonları olan hastalarda vitamin D eksikliğinin ve tedavisinin arter sertlik parametreleri üzerine etkisini araştırmaktır.Yöntemler: Çalışma grubu, vitamin D eksikliği olan, kalp fonksiyonları normal 45 hastadan oluştu. Hastaların ortanca yaşı 45.0 (12.00) yıl idi ve 33'ü kadındı. Hastalar oral vitamin D3 ile tedavi edildi. Arter sertlik parametreleri hastaların tedavi öncesinde ve tedavi sonrasında brakiyal arter akımını saptayan Mobil-O-Graph cihazı kullanılarak değerlendirildi.Bulgular: Vitamin D seviyeleri hastaların tedavisi sonrasında anlamlı olarak arttı (9.0 [6.00] nmol/L, 29.0 [11.50] nmol/L, p<0.001). Geleneksel ekokardiyografi parametreleri arasında, tedavi öncesi ve sonrasında anlamlı fark yoktu. Tedavi sonrası NDH ve AIx, bazal ölçümlere göre anlamlı olarak daha düşüktü (sırasıyla, 6.8 [1.55] m/s, 6.4 [1.30] m/s, p<0.001 ve 31.0 [14.50] %, 23.0 [22.00] %, p<0.001). Bazal vitamin D seviyesi NDH ile anlamlı ilişki saptandı (r=-0.352, p=0.018). Tedavi sonrası vitamin D seviyesi ile tedavi sonrası NDH (r=0.442, p=0.002) ve AIx (r=-0.419, p=0.004) arasında anlamlı ilişki saptandı. Çok değişkenli doğrusal regresyon analizinde, dönüştürülmüş bazal NDH'nin bağımsız öngördürücüsü saptanmadı.Sonuç: Vitamin D tedavisi arter sertlik parametreleri üzerine olumlu etkiler sağlamaktadır. Arter sertlik parametreleri vitamin D eksikliği olan hastalarda kadiyovasküler riskin değerlendirilmesinde klinikçiye yardımcı olabilir.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Arter sertlik parametreleri kalp fonksiyonları normal olan hastalardavitamin D eksikliği ve tedavisi ile ilişkilidir

Öz:

Objective: Arterial stiffness parameters including pulse wave velocity (PWV) and augmentation index (AIx) are associated with increased risk of cardiovascular disease. A close relationship has been demonstrated between vitamin D deficiency and cardiovascular disease. The aim of the present study was to investigate effects of vitamin D deficiency and supplementation on arterial stiffness parameters in patients with normal cardiac functions.Methods: Study population consisted of 45 patients with vitamin D deficiency and normal cardiac functions. Median age (interquartile range) was 45.0 (12.00) years, and 33 patients were female. Patients were treated with oral administration of vitamin D3. Arterial stiffness parameters were evaluated using Mobil-O-Graph arteriograph system, which detected signals from the brachial artery before and after treatment.Results: Vitamin D levels significantly increased after treatment (9.0 [6.00] nmol/L vs 29.0 [11.50] nmol/L, p<0.001). No significant difference was observed among conventional echocardiographic parameters before or after treatment. Post-treatment PVW and AIx were significantly lower than baseline measurements (6.8 [1.55] m/s vs 6.4 [1.30] m/s, p<0.001 and 23.0 [22.00]% vs 31.0 [14.50]%, p<0.001, respectively). Baseline vitamin D levels significantly correlated with PWV (r=-0.352, p=0.018). Posttreatment vitamin D levels also significantly correlated with posttreatment PWV (r=-0.442, p=0.002) and AIx (r=-0.419, p=0.004). Multivariate linear regression analysis revealed no independent predictor of baseline log-transformed PWV.Conclusion: Vitamin D supplementation has beneficial effects on arterial stiffness. Arterial stiffness parameters may aid in the assessment of cardiovascular risk in patients with vitamin D deficiency.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	SÜNBÜL M, Cincin A, BOZBAY M, MAMMADOV C, ATAŞ H, ÖZŞENEL E, Sarı İ, BAŞARAN Y (2016). Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions. , 281 - 288.
Chicago	SÜNBÜL MURAT,Cincin Altug,BOZBAY Mehmet,MAMMADOV Ceyhun,ATAŞ Halil,ÖZŞENEL Ekmel Burak,Sarı İbrahim,BAŞARAN Yelda Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions. (2016): 281 - 288.
MLA	SÜNBÜL MURAT,Cincin Altug,BOZBAY Mehmet,MAMMADOV Ceyhun,ATAŞ Halil,ÖZŞENEL Ekmel Burak,Sarı İbrahim,BAŞARAN Yelda Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions. , 2016, ss.281 - 288.
AMA	SÜNBÜL M,Cincin A,BOZBAY M,MAMMADOV C,ATAŞ H,ÖZŞENEL E,Sarı İ,BAŞARAN Y Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions. . 2016; 281 - 288.
Vancouver	SÜNBÜL M,Cincin A,BOZBAY M,MAMMADOV C,ATAŞ H,ÖZŞENEL E,Sarı İ,BAŞARAN Y Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions. . 2016; 281 - 288.
IEEE	SÜNBÜL M,Cincin A,BOZBAY M,MAMMADOV C,ATAŞ H,ÖZŞENEL E,Sarı İ,BAŞARAN Y "Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions." , ss.281 - 288, 2016.
ISNAD	SÜNBÜL, MURAT vd. "Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions". (2016), 281-288.

APA	SÜNBÜL M, Cincin A, BOZBAY M, MAMMADOV C, ATAŞ H, ÖZŞENEL E, Sarı İ, BAŞARAN Y (2016). Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions. Türk Kardiyoloji Derneği Arşivi, 44(4), 281 - 288.
Chicago	SÜNBÜL MURAT,Cincin Altug,BOZBAY Mehmet,MAMMADOV Ceyhun,ATAŞ Halil,ÖZŞENEL Ekmel Burak,Sarı İbrahim,BAŞARAN Yelda Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions. Türk Kardiyoloji Derneği Arşivi 44, no.4 (2016): 281 - 288.
MLA	SÜNBÜL MURAT,Cincin Altug,BOZBAY Mehmet,MAMMADOV Ceyhun,ATAŞ Halil,ÖZŞENEL Ekmel Burak,Sarı İbrahim,BAŞARAN Yelda Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions. Türk Kardiyoloji Derneği Arşivi, vol.44, no.4, 2016, ss.281 - 288.
AMA	SÜNBÜL M,Cincin A,BOZBAY M,MAMMADOV C,ATAŞ H,ÖZŞENEL E,Sarı İ,BAŞARAN Y Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions. Türk Kardiyoloji Derneği Arşivi. 2016; 44(4): 281 - 288.
Vancouver	SÜNBÜL M,Cincin A,BOZBAY M,MAMMADOV C,ATAŞ H,ÖZŞENEL E,Sarı İ,BAŞARAN Y Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions. Türk Kardiyoloji Derneği Arşivi. 2016; 44(4): 281 - 288.
IEEE	SÜNBÜL M,Cincin A,BOZBAY M,MAMMADOV C,ATAŞ H,ÖZŞENEL E,Sarı İ,BAŞARAN Y "Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions." Türk Kardiyoloji Derneği Arşivi, 44, ss.281 - 288, 2016.
ISNAD	SÜNBÜL, MURAT vd. "Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions". Türk Kardiyoloji Derneği Arşivi 44/4 (2016), 281-288.