Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease?

Çalışkan, Mustafa; Köstek, Osman; DEMİRCİOGLU, Kenan; AKSU, Feyza; AÇIKSARI, Gönül; CEKİN, Muhammed Esad; YILMAZ, YUSUF; KALÇIK, Macit; KELEŞ, Nurşen

Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease?

Nurşen KELEŞ, (İstanbul Medeniyet Üniversitesi, Göztepe Eğitim ve Araştırma Hastanesi Kardiyoloji Kliniği, İstanbul, Türkiye)

Feyza AKSU, (İstanbul Medeniyet Üniversitesi, Göztepe Eğitim ve Araştırma Hastanesi Kardiyoloji Kliniği, İstanbul, Türkiye)

Gönül AÇIKSARI, (İstanbul Medeniyet Üniversitesi, Göztepe Eğitim ve Araştırma Hastanesi Kardiyoloji Kliniği, İstanbul, Türkiye)

Yusuf YILMAZ, (İstanbul Medeniyet Üniversitesi, Göztepe Eğitim ve Araştırma Hastanesi Kardiyoloji Kliniği, İstanbul, Türkiye)

Kenan DEMİRCİOGLU, (İstanbul Medeniyet Üniversitesi, Göztepe Eğitim ve Araştırma Hastanesi Kardiyoloji Kliniği, İstanbul, Türkiye)

Osman KÖSTEK, (İstanbul Medeniyet Üniversitesi, Göztepe Eğitim ve Araştırma Hastanesi, İç Hastalıkları Anabilim Dalı, İstanbul, Türkiye)

Muhammed Esad CEKİN, (İstanbul Medeniyet Üniversitesi, Göztepe Eğitim ve Araştırma Hastanesi Kardiyoloji Kliniği, İstanbul, Türkiye)

Macit KALÇIK, (Iskilip Atif Hoca Devlet Hastanesi, Kardiyoloji Bölümü, Çorum, Türkiye)

Mustafa ÇALIŞKAN (İstanbul Medeniyet Üniversitesi, Göztepe Eğitim ve Araştırma Hastanesi Kardiyoloji Kliniği, İstanbul, Türkiye)

İstanbul Kuzey Klinikleri

1 1

Yıl: 2016 Cilt: 3 Sayı: 1 Sayfa Aralığı: 39 - 45 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease?

Öz:

OBJECTIVE: The term chronic inflammatory disease (CID) refers to a category of inflammatory diseases that includes Ankylosing spondylitis (AS) and familial Mediterranean fever (FMF). The incidence of adverse cardiovascular events is greater among patients with CID, though they may not have conventional atherosclerotic risk factors. Endothelial dysfunction is one of the underlying fundamental mechanisms that trigger development of atherosclerotic alterations in arteries, and flow-mediated dilatation (FMD) is a noninvasive method to determine endothelial dysfunction. Recent studies have shown a relationship between high triglyceride high-density lipoprotein cholesterol (TG/HDL-C) ratio and coronary atherosclerosis. Many studies have demonstrated that patients with CID have lower FMD values compared to healthy population, indicating endothelial dysfunction. However TG/HDL ratio and its relationship to FMD in patients with CID has not been investigated. The present study investigated whether TG/HDL ratio in CID patients differs from that of healthy population, and its relationship to FMD in patients with CID.METHODS: A total of 58 patients with CID and a group of 58 healthy volunteer individuals were enrolled in the study. FMD measurements were taken with high resolution ultrasound (US), and TG/HDL ratios were calculated.RESULTS: Patients with CID had significantly higher TG/HDL-C ratio (2.5 [2.2-2.8] vs 2.3 [2.1-2.5]; p=0.03) and lower FMD values (5.2 [4.2-6.3] vs 6.7 [6.3-9.7]; p<0.001), compared to healthy group, and a negative correlation was found between FMD levels and TG/HDL ratio of the study population.CONCLUSION: Higher TG/HDL ratio and lower FMD values found in CID patients may reflect increased atherosclerotic risk.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KELEŞ N, AKSU F, AÇIKSARI G, YILMAZ Y, DEMİRCİOGLU K, Köstek O, CEKİN M, KALÇIK M, Çalışkan M (2016). Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease?. , 39 - 45.
Chicago	KELEŞ Nurşen,AKSU Feyza,AÇIKSARI Gönül,YILMAZ YUSUF,DEMİRCİOGLU Kenan,Köstek Osman,CEKİN Muhammed Esad,KALÇIK Macit,Çalışkan Mustafa Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease?. (2016): 39 - 45.
MLA	KELEŞ Nurşen,AKSU Feyza,AÇIKSARI Gönül,YILMAZ YUSUF,DEMİRCİOGLU Kenan,Köstek Osman,CEKİN Muhammed Esad,KALÇIK Macit,Çalışkan Mustafa Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease?. , 2016, ss.39 - 45.
AMA	KELEŞ N,AKSU F,AÇIKSARI G,YILMAZ Y,DEMİRCİOGLU K,Köstek O,CEKİN M,KALÇIK M,Çalışkan M Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease?. . 2016; 39 - 45.
Vancouver	KELEŞ N,AKSU F,AÇIKSARI G,YILMAZ Y,DEMİRCİOGLU K,Köstek O,CEKİN M,KALÇIK M,Çalışkan M Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease?. . 2016; 39 - 45.
IEEE	KELEŞ N,AKSU F,AÇIKSARI G,YILMAZ Y,DEMİRCİOGLU K,Köstek O,CEKİN M,KALÇIK M,Çalışkan M "Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease?." , ss.39 - 45, 2016.
ISNAD	KELEŞ, Nurşen vd. "Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease?". (2016), 39-45.

APA	KELEŞ N, AKSU F, AÇIKSARI G, YILMAZ Y, DEMİRCİOGLU K, Köstek O, CEKİN M, KALÇIK M, Çalışkan M (2016). Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease?. İstanbul Kuzey Klinikleri, 3(1), 39 - 45.
Chicago	KELEŞ Nurşen,AKSU Feyza,AÇIKSARI Gönül,YILMAZ YUSUF,DEMİRCİOGLU Kenan,Köstek Osman,CEKİN Muhammed Esad,KALÇIK Macit,Çalışkan Mustafa Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease?. İstanbul Kuzey Klinikleri 3, no.1 (2016): 39 - 45.
MLA	KELEŞ Nurşen,AKSU Feyza,AÇIKSARI Gönül,YILMAZ YUSUF,DEMİRCİOGLU Kenan,Köstek Osman,CEKİN Muhammed Esad,KALÇIK Macit,Çalışkan Mustafa Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease?. İstanbul Kuzey Klinikleri, vol.3, no.1, 2016, ss.39 - 45.
AMA	KELEŞ N,AKSU F,AÇIKSARI G,YILMAZ Y,DEMİRCİOGLU K,Köstek O,CEKİN M,KALÇIK M,Çalışkan M Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease?. İstanbul Kuzey Klinikleri. 2016; 3(1): 39 - 45.
Vancouver	KELEŞ N,AKSU F,AÇIKSARI G,YILMAZ Y,DEMİRCİOGLU K,Köstek O,CEKİN M,KALÇIK M,Çalışkan M Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease?. İstanbul Kuzey Klinikleri. 2016; 3(1): 39 - 45.
IEEE	KELEŞ N,AKSU F,AÇIKSARI G,YILMAZ Y,DEMİRCİOGLU K,Köstek O,CEKİN M,KALÇIK M,Çalışkan M "Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease?." İstanbul Kuzey Klinikleri, 3, ss.39 - 45, 2016.
ISNAD	KELEŞ, Nurşen vd. "Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease?". İstanbul Kuzey Klinikleri 3/1 (2016), 39-45.