Objectives: Pregnancy is one of stressful periods in thelife of a woman and often combines with anxiety anddepression. In this study we aimed to determine thepresence of depression and anxiety and their relationship between socio-demographic characteristics in thefirst trimester of pregnancy by using the Primary CareEvaluation of Mental Disorders (PRIME-MD). Method: Atotal of 111 pregnant women who have not any psychiatric disorder before were included in the study group.The demographic characteristics and the obstetric histories of the patients were recorded. In order to investigatepresence of psychiatric disorders, PRIME-MD patientquestionnaire was used. Results: Of the 111 women inthe study group 55.8% (n=62) had one or more psychiatric symptoms with the assessment by PRIME-MD system. 21.6% (n=24) of them had both anxiety anddepression symptoms. The rate of anxiety and depression were significantly high in pregnant women whowere >30 years of age. It was found that depression andanxiety were increased as the number of the pregnanciesincreased (p=0.034, p=0.03, respectively). The rate ofdepression was high in pregnant women who did notplanned pregnancy (p=0.001). Conclusion: Pregnantwomen are a risk group for the development of anxietyand depression. Considering this situation, physiciansworking in primary health care can do psychiatric evaluation at follow-up of pregnant women by using toolssuch as PRIME-MD. Thus, with early diagnosis and treatment of the present disorder the complications that constitute risk for the health of the mother and the child canbe prevented