Meme Koruyucu Cerrahi ve Sentinel Lenf Nodu Biyopsisi Uygulanan Hastalarda Lokal-Aksiller Rekürrens Oranı ve Etkileyen Faktörler
Yıl: 2015 Cilt: 31 Sayı: 1 Sayfa Aralığı: 27 - 33 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
Meme Koruyucu Cerrahi ve Sentinel Lenf Nodu Biyopsisi Uygulanan Hastalarda Lokal-Aksiller Rekürrens Oranı ve Etkileyen Faktörler
Öz: Meme kanserinin cerrahi tedavisinde sentinel lenf nodu biyopsisi (SLNB) prosedürü, aksiller lenf nodu diseksiyonuna (ALND) alternatif olarak geliştirilmiş ve düşük morbidite ile güvenli bir evreleme yöntemidir. Bu çalışmadaki amacımız Meme Koruyucu Cerrahi (MKC) + SLNB uygulanan hastalarda uzun dönemli takiplerde nüks oranlarını ve bunu etkileyen faktörleri saptamaktır.Gereç ve Yöntemler: Çalışmamıza 2006 ile 2011 tarihleri arasında erken evre meme kanseri nedeniyle MKC ve SLNB uygulanan 171 hasta dâhil edildi. Hastaların 62'sinde sentinel lenf nodu (SLN) pozitif gelmesi üzerine level 1-2 aksiller diseksiyon uygulandı. SLNB (-) ve (+) gelen iki hasta grubu ortalama 36 ay klinik ve radyolojik olarak takip edildi. Her iki gruptaki loko-rejyonel nüks ve metastaz oranları karşılaştırıldı. Literatür desteği ile aksiller lenf nodu pozitifliğini ve loko-rejyonel nüksü etkileyebilecek faktörler olarak; hastaların yaşı, menopozal durumu, tümör lokalizasyonu, tümör histolojisi, SLN boyutu, östrojen-progesteron reseptörü, c-erb-B2 pozitifliği, tümör grade'i, ekstensif intraduktal komponent (EİC) varlığı, tümör boyutu ve lenfovasküler invazyon (LVİ) varlığı incelendi.Bulgular: Yüz yetmiş bir hasta ortalama 36 ay takip edildi. SLNB (-) olan grupta ameliyattan 25 ay sonra 1 hastada aksiller nüks geliştiği saptandı, nüks oranı % 0,92'dir. SLNB (-) olan grupta lokal nüks saptanmadı. SLNB (+) gelip ALND uygulanan grupta aksiller nüks saptanmazken, 4 hastada (% 5,84) lokal nüks saptandı. On sekiz hastamızda da uzak organ metastazı belirlendi. Lokal nüks SLNB (-) olan grupta anlamlı olarak daha az iken, aksiller nüks ve uzak organ metastazı açısından iki grup arasında anlamlı fark saptanmadı. Tümör boyutu (p=0.002), LVİ varlığı (p<0.001), hastalığın evresi (p<0.001) ve SLN boyutu (p=0.014) SLN pozitifliğini etkileyen faktörler olarak saptandı.Sonuç: SLNB lokorejyonal nüks ve uzak organ metastazı açısından ALND kadar güvenilir bir yöntemdir
Anahtar Kelime: Konular:
Local-Axillary Recurrence Rate and Affecting Factors in Patients Undergoing Breast-Conserving Surgery and Sentinel Lymph Node Biopsy
Öz: SLNB procedure is developed as an alternative to ALND in surgical therapy of breast cancer and is a safe staging method with low morbidity. Our objective in the present study is to determine relapse rates in long-term follow up and the affecting factors in patients who underwent breast-conserving surgery (BCS) + SLNB.Material and Methods: In this study 171 patients treated with BCS and SLNB between 2006 and 2011, for early stage breast cancer were included. In 62 of 171 patients, SLN was positive and Level 1-2 axillary dissection was applied to them. Two group of patients who had SLNB (-) and (+) have been followed up clinically and radiologically for averagely 36 months. Locoregional recurrence and metastasis rates were compared for both groups. In the lights of literature, age of patients, menopausal situation, localization of tumor, histology of tumor, size of SLN, estrogen-progesterone receptor and C erb-B2 positivity, grade of tumor, existence of extensive intraductal component, size of tumor and lymphovascular invasion were examined as possible factors that may affect rates of axillary lymph node positivity and local-axillary relapse.Results: 171 patients were followed up 36 months. In the SLNB (-) group only one patient had axillary relapse 25 months after primary surgery. Relapse rate was 0.92 %. None of SLNB (-) patients had local relapse. In the SLNB (+) group, patients underwent ALND and no one had axillary relapse, 4 had local relapse (5.84 %). 18 patients had distant metastasis. SLNB (-) patients were significantly less likely to develop local relapse. There was no significant difference in axillary relapse and distant metastasis for both groups. Size of tumor, existence of LVI, stage of disease and size of SLN were the factors affecting SLN positivity.Conclusion: SLNB is as reliable as ALND when locoregional relapse and distant metastasis is concerned
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Büyükakıncak S, YÜRÜKER S, KOCA B, KESİCİOĞLU T, ÇINAR H, EKEN H, KARABICAK İ, ÖZEN N (2015). Meme Koruyucu Cerrahi ve Sentinel Lenf Nodu Biyopsisi Uygulanan Hastalarda Lokal-Aksiller Rekürrens Oranı ve Etkileyen Faktörler. , 27 - 33. |
| Chicago | Büyükakıncak Sercan,YÜRÜKER SAIM SAVAS,KOCA Bülent,KESİCİOĞLU TUĞRUL,ÇINAR Hamza,EKEN HÜSEYİN,KARABICAK İlhan,ÖZEN NECATİ Meme Koruyucu Cerrahi ve Sentinel Lenf Nodu Biyopsisi Uygulanan Hastalarda Lokal-Aksiller Rekürrens Oranı ve Etkileyen Faktörler. (2015): 27 - 33. |
| MLA | Büyükakıncak Sercan,YÜRÜKER SAIM SAVAS,KOCA Bülent,KESİCİOĞLU TUĞRUL,ÇINAR Hamza,EKEN HÜSEYİN,KARABICAK İlhan,ÖZEN NECATİ Meme Koruyucu Cerrahi ve Sentinel Lenf Nodu Biyopsisi Uygulanan Hastalarda Lokal-Aksiller Rekürrens Oranı ve Etkileyen Faktörler. , 2015, ss.27 - 33. |
| AMA | Büyükakıncak S,YÜRÜKER S,KOCA B,KESİCİOĞLU T,ÇINAR H,EKEN H,KARABICAK İ,ÖZEN N Meme Koruyucu Cerrahi ve Sentinel Lenf Nodu Biyopsisi Uygulanan Hastalarda Lokal-Aksiller Rekürrens Oranı ve Etkileyen Faktörler. . 2015; 27 - 33. |
| Vancouver | Büyükakıncak S,YÜRÜKER S,KOCA B,KESİCİOĞLU T,ÇINAR H,EKEN H,KARABICAK İ,ÖZEN N Meme Koruyucu Cerrahi ve Sentinel Lenf Nodu Biyopsisi Uygulanan Hastalarda Lokal-Aksiller Rekürrens Oranı ve Etkileyen Faktörler. . 2015; 27 - 33. |
| IEEE | Büyükakıncak S,YÜRÜKER S,KOCA B,KESİCİOĞLU T,ÇINAR H,EKEN H,KARABICAK İ,ÖZEN N "Meme Koruyucu Cerrahi ve Sentinel Lenf Nodu Biyopsisi Uygulanan Hastalarda Lokal-Aksiller Rekürrens Oranı ve Etkileyen Faktörler." , ss.27 - 33, 2015. |
| ISNAD | Büyükakıncak, Sercan vd. "Meme Koruyucu Cerrahi ve Sentinel Lenf Nodu Biyopsisi Uygulanan Hastalarda Lokal-Aksiller Rekürrens Oranı ve Etkileyen Faktörler". (2015), 27-33. |
| APA | Büyükakıncak S, YÜRÜKER S, KOCA B, KESİCİOĞLU T, ÇINAR H, EKEN H, KARABICAK İ, ÖZEN N (2015). Meme Koruyucu Cerrahi ve Sentinel Lenf Nodu Biyopsisi Uygulanan Hastalarda Lokal-Aksiller Rekürrens Oranı ve Etkileyen Faktörler. Okmeydanı Tıp Dergisi, 31(1), 27 - 33. |
| Chicago | Büyükakıncak Sercan,YÜRÜKER SAIM SAVAS,KOCA Bülent,KESİCİOĞLU TUĞRUL,ÇINAR Hamza,EKEN HÜSEYİN,KARABICAK İlhan,ÖZEN NECATİ Meme Koruyucu Cerrahi ve Sentinel Lenf Nodu Biyopsisi Uygulanan Hastalarda Lokal-Aksiller Rekürrens Oranı ve Etkileyen Faktörler. Okmeydanı Tıp Dergisi 31, no.1 (2015): 27 - 33. |
| MLA | Büyükakıncak Sercan,YÜRÜKER SAIM SAVAS,KOCA Bülent,KESİCİOĞLU TUĞRUL,ÇINAR Hamza,EKEN HÜSEYİN,KARABICAK İlhan,ÖZEN NECATİ Meme Koruyucu Cerrahi ve Sentinel Lenf Nodu Biyopsisi Uygulanan Hastalarda Lokal-Aksiller Rekürrens Oranı ve Etkileyen Faktörler. Okmeydanı Tıp Dergisi, vol.31, no.1, 2015, ss.27 - 33. |
| AMA | Büyükakıncak S,YÜRÜKER S,KOCA B,KESİCİOĞLU T,ÇINAR H,EKEN H,KARABICAK İ,ÖZEN N Meme Koruyucu Cerrahi ve Sentinel Lenf Nodu Biyopsisi Uygulanan Hastalarda Lokal-Aksiller Rekürrens Oranı ve Etkileyen Faktörler. Okmeydanı Tıp Dergisi. 2015; 31(1): 27 - 33. |
| Vancouver | Büyükakıncak S,YÜRÜKER S,KOCA B,KESİCİOĞLU T,ÇINAR H,EKEN H,KARABICAK İ,ÖZEN N Meme Koruyucu Cerrahi ve Sentinel Lenf Nodu Biyopsisi Uygulanan Hastalarda Lokal-Aksiller Rekürrens Oranı ve Etkileyen Faktörler. Okmeydanı Tıp Dergisi. 2015; 31(1): 27 - 33. |
| IEEE | Büyükakıncak S,YÜRÜKER S,KOCA B,KESİCİOĞLU T,ÇINAR H,EKEN H,KARABICAK İ,ÖZEN N "Meme Koruyucu Cerrahi ve Sentinel Lenf Nodu Biyopsisi Uygulanan Hastalarda Lokal-Aksiller Rekürrens Oranı ve Etkileyen Faktörler." Okmeydanı Tıp Dergisi, 31, ss.27 - 33, 2015. |
| ISNAD | Büyükakıncak, Sercan vd. "Meme Koruyucu Cerrahi ve Sentinel Lenf Nodu Biyopsisi Uygulanan Hastalarda Lokal-Aksiller Rekürrens Oranı ve Etkileyen Faktörler". Okmeydanı Tıp Dergisi 31/1 (2015), 27-33. |
